Uncoupling skeletal and connective tissue patterning: Conditional deletion in cartilage progenitors reveals cell-autonomous requirements for Lmx1b in dorsal-ventral limb patterning

Development

Volumn 137, Issue 7, 2010, Pages 1181-1188

  Li, Ying ^a,b   Qiu, Qiong ^c   Watson, Spenser S ^d   Schweitzer, Ronen ^d   Johnson, Randy L ^a,b  

^a UNIVERSITY OF TEXAS   (United States)

^b UNIVERSITY OF TEXAS   (United States)

^c DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d SHRINERS HOSPITAL FOR CHILDREN   (United States)

Author keywords

Dorsal ventral patterning; Limb development; Lmx1b; Mouse

Indexed keywords

CRE RECOMBINASE; TRANSCRIPTION FACTOR LHX3; TRANSCRIPTION FACTOR SOX9; HOMEODOMAIN PROTEIN; LIM HOMEOBOX TRANSCRIPTION FACTOR 1 BETA; SOX9 PROTEIN, MOUSE; TRANSCRIPTION FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARTILAGE CELL; CONNECTIVE TISSUE; CONTROLLED STUDY; LIMB DEVELOPMENT; MOUSE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SKELETAL MUSCLE; STEM CELL; ANIMAL; BONE; CARTILAGE; CELL LINEAGE; CYTOLOGY; GENE TARGETING; GENETICS; HISTOLOGY; JOINT; LIMB; MESODERM; METABOLISM; MORPHOGENESIS; PHENOTYPE; PHYSIOLOGY; PRENATAL DEVELOPMENT; TRANSGENIC MOUSE;

ANIMALS; ANIMALS, NEWBORN; BODY PATTERNING; BONE AND BONES; CARTILAGE; CELL LINEAGE; CONNECTIVE TISSUE; EXTREMITIES; GENE KNOCK-IN TECHNIQUES; HOMEODOMAIN PROTEINS; JOINTS; MESODERM; MICE; MICE, TRANSGENIC; MUSCLE, SKELETAL; PHENOTYPE; SOX9 TRANSCRIPTION FACTOR; STEM CELLS; TRANSCRIPTION FACTORS;

EID: 77950463649     PISSN: 09501991     EISSN: 14779129     Source Type: Journal    
DOI: 10.1242/dev.045237     Document Type: Article

References (27)

1. Akiyama, H., Chaboissier, M. C., Martin, J. F., Schedl, A. and de Crombrugghe, B. (2002). The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6. Genes Dev. 16, 2813-2828. (Pubitemid 35253149)
2. Arques, C. G., Doohan, R., Sharpe, J. and Torres, M. (2007). Cell tracing reveals a dorsoventral lineage restriction plane in the mouse limb bud mesenchyme. Development 134, 3713-3722. (Pubitemid 350104380)
3. Blitz, E., Viukov, S., Sharir, A., Shwartz, Y., Galloway, J. L., Pryce, B. A., Johnson, R. L., Tabin, C. J., Schweitzer, R. and Zelzer, E. (2009). Bone ridge patterning during musculoskeletal assembly is mediated through SCX regulation of Bmp4 at the tendon-skeleton junction. Dev. Cell 17, 861-873.
4. Brent, A. E., Braun, T. and Tabin, C. J. (2005). Genetic analysis of interactions between the somitic muscle, cartilage and tendon cell lineages during mouse development. Development 132, 515-528. (Pubitemid 40277692)
5. Chen, H. and Johnson, R. L. (1999). Dorsoventral patterning of the vertebrate limb: a process governed by multiple events. Cell Tissue Res. 296, 67-73. (Pubitemid 29179373)
6. Chen, H., Lun, Y., Ovchinnikov, D., Kokubo, H., Oberg, K. C., Pepicelli, C. V., Gan, L., Lee, B. and Johnson, R. L. (1998). Limb and kidney defects in Lmx1b mutant mice suggest an involvement of LMX1B in human nail patella syndrome. Nat. Genet. 19, 51-55. (Pubitemid 28242022)
7. Chevallier, A., Kieny, M. and Mauger, A. (1977). Limb-somite relationship: origin of the limb musculature. J. Embryol. Exp. Morphol. 41, 245-258. (Pubitemid 8188030)
8. Christ, B., Jacob, H. J. and Jacob, M. (1977). Experimental analysis of the origin of the wing musculature in avian embryos. Anat. Embryol. (Berl.) 150, 171-186. (Pubitemid 8068337)
9. Ding, Y. Q., Marklund, U., Yuan, W., Yin, J., Wegman, L., Ericson, J., Deneris, E., Johnson, R. L. and Chen, Z. F. (2003). Lmx1b is essential for the development of serotonergic neurons. Nat. Neurosci. 6, 933-938. (Pubitemid 37064754)
10. Dreyer, S. D., Zhou, G., Baldini, A., Winterpacht, A., Zabel, B., Cole, W., Johnson, R. L. and Lee, B. (1998). Mutations in LMX1B cause abnormal skeletal patterning and renal dysplasia in nail patella syndrome. Nat. Genet. 19, 47-50. (Pubitemid 28242021)
11. Dreyer, S. D., Naruse, T., Morello, R., Zabel, B., Winterpacht, A., Johnson, R. L., Lee, B. and Oberg, K. C. (2004). Lmx1b expression during joint and tendon formation: localization and evaluation of potential downstream targets. Gene Expr. Patterns 4, 397-405. (Pubitemid 38756235)
12. Halder, G., Polaczyk, P., Kraus, M. E., Hudson, A., Kim, J., Laughon, A. and Carroll, S. (1998). The Vestigial and Scalloped proteins act together to directly regulate wing-specific gene expression in Drosophila. Genes Dev. 12, 3900-3909. (Pubitemid 29024852)
13. Hayashi, S. and McMahon, A. P. (2002). Efficient recombination in diverse tissues by a tamoxifen-inducible form of Cre: a tool for temporally regulated gene activation/inactivation in the mouse. Dev. Biol. 244, 305-318. (Pubitemid 34450645)
14. Jacob, H. J. and Christ, B. (1980). On the formation of muscular pattern in the chick limb. In Teratology of the Limbs: Fourth Symposium on Prenatal Development (ed. H.-J. Merker, H. Nau and D. Neubert), p89. Berlin: Walter De Gruyter and Company.
15. Johnson, R. L. and Tabin, C. J. (1997). Molecular models for vertebrate limb development. Cell 90, 979-990. (Pubitemid 27408512)
16. Kania, A. and Jessell, T. M. (2003). Topographic motor projections in the limb imposed by LIM homeodomain protein regulation of ephrin-A:EphA interactions. Neuron 38, 581-596. (Pubitemid 36645033)
17. Kardon, G. (1998). Muscle and tendon morphogenesis in the avian hind limb. Development 125, 4019-4032.
18. Kardon, G., Campbell, J. K. and Tabin, C. J. (2002). Local extrinsic signals determine muscle and endothelial cell fate and patterning in the vertebrate limb. Dev. Cell 3, 533-545. (Pubitemid 35252262)
19. Krawchuk, D. and Kania, A. (2008). Identification of genes controlled by LMX1B in the developing mouse limb bud. Dev. Dyn. 237, 1183-1192. (Pubitemid 351542314)
20. Logan, M., Martin, J. F., Nagy, A., Lobe, C., Olson, E. N. and Tabin, C. J. (2002). Expression of Cre recombinase in the developing mouse limb bud driven by a Prxl enhancer. Genesis 33, 77-80. (Pubitemid 34651279)
21. Mann, R. S. and Carroll, S. B. (2002). Molecular mechanisms of selector gene function and evolution. Curr. Opin. Genet. Dev. 12, 592-600. (Pubitemid 35013541)
22. Pearse, R. V., II, Scherz, P. J., Campbell, J. K. and Tabin, C. J. (2007). A cellular lineage analysis of the chick limb bud. Dev. Biol. 310, 388-400.
23. Qiu, Q., Chen, H. and Johnson, R. L. (2009). Lmx1b-expressing cells in the mouse limb bud define a dorsal mesenchymal lineage compartment. Genesis 47, 224-233.
24. Riddle, R. D., Ensini, M., Nelson, C., Tsuchida, T., Jessell, T. M. and Tabin, C. (1995). Induction of the LIM homeobox gene Lmx1 by WNT7a establishes dorsoventral pattern in the vertebrate limb. Cell 83, 631-640.
25. Schweizer, H., Johnson, R. L. and Brand-Saberi, B. (2004). Characterization of migration behavior of myogenic precursor cells in the limb bud with respect to Lmx1b expression. Anat. Embryol. (Berl.) 208, 7-18. (Pubitemid 38553618)
26. Soriano, P. (1999). Generalized lacZ expression with the ROSA26 Cre reporter strain. Nat. Genet. 21, 70-71.
27. Vogel, A., Rodriguez, C., Warnken, W. and Izpisua Belmonte, J. C. (1995). Dorsal cell fate specified by chick Lmx1 during vertebrate limb development. Nature 378, 716-720.