Enantioselective quantification of carvedilol in human plasma by HPLC in heavily medicated heart failure patients

Journal of Pharmaceutical and Biomedical Analysis

Volumn 52, Issue 4, 2010, Pages 636-641

  Zakrzewski Jakubiak, Marcin ^a   de Denus, Simon ^b   Leblanc, Marie Hélène ^c   White, Michel ^b   Turgeon, Jacques ^a  

^a CENTRE HOSPITALIER DE L UNIVERSITÉ DE MONTRÉAL   (Canada)

^b MONTREAL HEART INSTITUTE   (Canada)

^c LAVAL UNIVERSITY   (Canada)

Author keywords

Carvedilol; Enantiomer; HPLC; Plasma; Stereoselective

Indexed keywords

ACETONITRILE; CARVEDILOL; PROPRANOLOL; TERT BUTYL METHYL ETHER; WATER; CARBAZOLE DERIVATIVE; PROPANOLAMINE DERIVATIVE;

ACCURACY; ARTICLE; CHIRALITY; CONTROLLED STUDY; DERIVATIZATION; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG ISOLATION; DRUG STRUCTURE; ENANTIOMER; ENANTIOSELECTIVITY; FLUORESCENCE ANALYSIS; HEART FAILURE; HUMAN; LIQUID LIQUID EXTRACTION; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SENSITIVITY AND SPECIFICITY; SEPARATION TECHNIQUE; STEREOCHEMISTRY; STRUCTURE ANALYSIS; BLOOD; CHEMISTRY; CLINICAL TRIAL; COMPARATIVE STUDY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PROCEDURES; STEREOISOMERISM;

CARBAZOLES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HEART FAILURE; HUMANS; PROPANOLAMINES; STEREOISOMERISM;

EID: 77950371372     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2010.02.002     Document Type: Article

References (10)

1. Frishman W.H. Carvedilol. N. Engl. J. Med. 1998, 339:1759-1765.
2. Stoschitzky K., Koshucharova G., Lercher P., Maier R., Sakotnik A., Klein W., Liebmann P.M., Lindner W. Stereoselective effects of (R)- and (S)-carvedilol in humans. Chirality 2001, 13:342-346.
3. Neugebauer G., Akpan W., Kaufmann B., Reiff K. Stereoselective disposition of carvedilol in man after intravenous and oral administration of the racemic compound. Eur. J. Clin. Pharmacol. 1990, 38(Suppl 2):S108-S111.
4. Saito M., Kawana J., Ohno T., Kaneko M., Mihara K., Hanada K., Sugita R., Okada N., Oosato S., Nagayama M., Sumiyoshi T., Ogata H. Enantioselective and highly sensitive determination of carvedilol in human plasma and whole blood after administration of the racemate using normal-phase high-performance liquid chromatography. J. Chromatogr. B Anal. Technol. Biomed. Life Sci. 2006, 843:73-77.
5. Eisenberg E.J., Patterson W.R., Kahn G.C. High-performance liquid chromatographic method for the simultaneous determination of the enantiomers of carvedilol and its O-desmethyl metabolite in human plasma after chiral derivatization. J. Chromatogr. 1989, 493:105-115.
6. Peccinini R.G., Ximenes V.F., Cesarino E.J., Lanchote V.L. Stereoselective analysis of carvedilol in human plasma and urine using HPLC after chiral derivatization. Biopharm. Drug Dispos. 2008, 29:280-288.
7. Spahn H., Henke W., Langguth P., Schloos J., Mutschler E. Measurement of carvedilol enantiomers in human plasma and urine using S-naproxen chloride for chiral derivatization. Arch. Pharm. (Weinheim) 1990, 323:465-469.
8. Stahl E., Mutschler E., Baumgartner U., Spahn-Langguth H. Carvedilol stereopharmacokinetics in rats: affinities to blood constituents and tissues. Arch. Pharm. (Weinheim) 1993, 326:529-533.
9. Clohs L., McErlane K.M. Comparison between capillary electrophoresis and high-performance liquid chromatography for the stereoselective analysis of carvedilol in serum. J. Pharm. Biomed. Anal. 2003, 31:407-412.
10. Yang E., Wang S., Kratz J., Cyronak M.J. Stereoselective analysis of carvedilol in human plasma using HPLC/MS/MS after chiral derivatization. J. Pharm. Biomed. Anal. 2004, 36:609-615.