Differential expression of VE-cadherin and VEGFR2 in placental syncytiotrophoblast during preeclampsia - New perspectives to explain the pathophysiology

Placenta

Volumn 31, Issue 4, 2010, Pages 339-343

  Groten, T ^a,b   Gebhard, N ^a   Kreienberg, R ^a   Schleussner E ^b   Reister, F ^a   Huppertz, B ^c  

^a UNIVERSITY OF ULM   (Germany)

^b JENA UNIVERSITY HOSPITAL   (Germany)

^c MEDICAL UNIVERSITY OF GRAZ   (Austria)

Author keywords

Preeclampsia; Syncytiotrophoblast; VE cadherin; VEGFR2

Indexed keywords

SMALL INTERFERING RNA; VASCULAR ENDOTHELIAL CADHERIN; VASCULOTROPIN RECEPTOR 2;

ADULT; ARTICLE; CELL FUSION; CELL SURVIVAL; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROL GROUP; CONTROLLED STUDY; FEMALE; GESTATIONAL AGE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; PATHOPHYSIOLOGY; PLACENTA; PLACENTA VILLUS; PREECLAMPSIA; PREGNANCY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STAINING; SYNCYTIOTROPHOBLAST; UPREGULATION; WESTERN BLOTTING;

ADULT; ANTIGENS, CD; CADHERINS; CELL LINE; FEMALE; GENE EXPRESSION; HUMANS; PLACENTA; PRE-ECLAMPSIA; PREGNANCY; TROPHOBLASTS; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 77950369367     PISSN: 01434004     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.placenta.2010.01.014     Document Type: Article

References (25)

1. Kingdom J., Huppertz B., Seaward G., and Kaufmann P. Development of the placental villous tree and its consequences for fetal growth. Eur J Obstet Gynecol Reprod Biol 92 (2000) 35-43
2. Huppertz B., Frank H.G., Kingdom J.C., Reister F., and Kaufmann P. Villous cytotrophoblast regulation of the syncytial apoptotic cascade in the human placenta. Histochem Cell Biol 110 (1998) 495-508
3. Huppertz B., and Kingdom J.C. Apoptosis in the trophoblast-role of apoptosis in placental morphogenesis. J Soc Gynecol Investig 11 (2004) 353-362
4. Arnholdt H., Meisel F., Fandrey K., and Lohrs U. Proliferation of villous trophoblast of the human placenta in normal and abnormal pregnancies. Virchows Arch B Cell Pathol Incl Mol Pathol 60 (1991) 365-372
5. Goswami D., Tannetta D.S., Magee L.A., Fuchisawa A., Redman C.W., Sargent I.L., et al. Excess syncytiotrophoblast microparticle shedding is a feature of early-onset pre-eclampsia, but not normotensive intrauterine growth restriction. Placenta 27 (2006) 56-61
6. Redman C.W., and Sargent I.L. Microparticles and immunomodulation in pregnancy and pre-eclampsia. J Reprod Immunol 76 (2007) 61-67
7. Takeichi M. Cadherin cell adhesion receptors as a morphogenetic regulator. Science 251 (1991) 1451-1455
8. Yap A.S., Crampton M.S., and Hardin J. Making and breaking contacts: the cellular biology of cadherin regulation. Curr Opin Cell Biol 19 (2007) 508-514
9. Lampugnani M.G., Resnati M., Raiteri M., Pigott R., Pisacane A., Houen G., et al. A novel endothelial-specific membrane protein is a marker of cell-cell contacts. J Cell Biol 118 (1992) 1511-1522
10. Levine R.J., Maynard S.E., Qian C., Lim K.H., England L.J., Yu K.F., et al. Circulating angiogenic factors and the risk of preeclampsia. N Engl J Med 350 (2004) 672-683
11. Groten T., Pierce A.A., Huen A.C., and Schnaper H.W. 17 Beta-estradiol transiently disrupts adherens junctions in endothelial cells. FASEB J 19 (2005) 1368-1370
12. Mayhew T.M. Taking tissue samples from the placenta: an illustration of principles and strategies. Placenta 29 (2008) 1-14
13. Voigt M., Schneider K.T., and Jahrig K. Analysis of a 1992 birth sample in Germany. 1: new percentile values of the body weight of newborn infants. Geburtshilfe Frauenheilkd 56 (1996) 550-558
14. Getsios S., and MacCalman C.D. Cadherin-11 modulates the terminal differentiation and fusion of human trophoblastic cells in vitro. Dev Biol 257 (2003) 41-54
15. Bulla R., Villa A., Bossi F., Cassetti A., Radillo O., Spessotto P., et al. VE-cadherin is a critical molecule for trophoblast-endothelial cell interaction in decidual spiral arteries. Exp Cell Res 303 (2005) 101-113
16. Challier J.C., Carbillon L., Kacemi A., Vervelle C., Bintein T., Galtier M., et al. Characterization of first trimester human fetal placental vessels using immunocytochemical markers. Cell Mol Biol (Noisy-le-grand) 47 (2001) Online Pub:OL79-87
17. Tabata T., McDonagh S., Kawakatsu H., and Pereira L. Cytotrophoblasts infected with a pathogenic human cytomegalovirus strain dysregulate cell-matrix and cell-cell adhesion molecules: a quantitative analysis. Placenta 28 (2007) 527-537
18. Leach L., Lammiman M.J., Babawale M.O., Hobson S.A., Bromilou B., Lovat S., et al. Molecular organization of tight and adherens junctions in the human placental vascular tree. Placenta 21 (2000) 547-557
19. Dye J.F., Jablenska R., Donnelly J.L., Lawrence L., Leach L., Clark P., et al. Phenotype of the endothelium in the human term placenta. Placenta 22 (2001) 32-43
20. Leach L., Gray C., Staton S., Babawale M.O., Gruchy A., Foster C., et al. Vascular endothelial cadherin and beta-catenin in human fetoplacental vessels of pregnancies complicated by type 1 diabetes: associations with angiogenesis and perturbed barrier function. Diabetologia 47 (2004) 695-709
21. Kudo Y., Boyd C.A., Sargent I.L., Redman C.W., Lee J.M., and Freeman T.C. An analysis using DNA microarray of the time course of gene expression during syncytialization of a human placental cell line (BeWo). Placenta 25 (2004) 479-488
22. Vestweber D. VE-cadherin: the major endothelial adhesion molecule controlling cellular junctions and blood vessel formation. Arterioscler Thromb Vasc Biol 28 (2008) 223-232
23. Nunez G., and del Peso L. Linking extracellular survival signals and the apoptotic machinery. Curr Opin Neurobiol 8 (1998) 613-618
24. Carmeliet P., Lampugnani M.G., Moons L., Breviario F., Compernolle V., Bono F., et al. Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis. Cell 98 (1999) 147-157
25. Lampugnani M.G., Orsenigo F., Gagliani M.C., Tacchetti C., and Dejana E. Vascular endothelial cadherin controls VEGFR-2 internalization and signaling from intracellular compartments. J Cell Biol 174 (2006) 593-604