Isolation and structure characterization of related impurities in 10-O-(N,N-dimethylaminoethyl)-ginkgolide B methanesulfonate (XQ-1H) bulk drug and quantitation by a validated RP-LC

Journal of Pharmaceutical and Biomedical Analysis

Volumn 52, Issue 4, 2010, Pages 603-608

  Liu, Wenyuan ^a   Li, Ping ^a   Feng, Feng ^a   Mao, Lishun ^b  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b Jiangsu Carefree Medicinal Company Limited   (China)

Author keywords

10 O (N,N dimethylaminoethyl) ginkgolide B methanesulfonate; Preparative liquid chromatography; Related impurities; Reversed phase liquid chromatography

Indexed keywords

10 O (N,N DIMETHYLAMINOETHYL) 11,12 SECO GINKGOLIDE B METHANESULFONATE; 10 O (N,N DIMETHYLAMINOETHYL) 11,12,2,15 DISECO 3,14 DEHYDROGINKGOLIDE B METHANESULFONATE; 10 O (N,N DIMETHYLAMINOETHYL)GINKGOLIDE B METHANESULFONATE; DIPOTASSIUM HYDROGEN PHOSPHATE; GINKGOLIDE DERIVATIVE; METHANOL; THROMBOCYTE ACTIVATING FACTOR ANTAGONIST; UNCLASSIFIED DRUG; XQ 1H; ETHYLAMINE; GINKGOLIDE; GINKGOLIDE B; LACTONE; MESYLIC ACID; MESYLIC ACID DERIVATIVE;

ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DENSITY GRADIENT; DRUG IDENTIFICATION; DRUG IMPURITY; DRUG ISOLATION; DRUG STRUCTURE; FLOW RATE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PH MEASUREMENT; PRIORITY JOURNAL; PROCESS OPTIMIZATION; REVERSED PHASE LIQUID CHROMATOGRAPHY; SCALE UP; STRUCTURE ANALYSIS; TANDEM MASS SPECTROMETRY; VALIDATION STUDY; CHEMISTRY; COMPARATIVE STUDY; DRUG CONTAMINATION; ISOLATION AND PURIFICATION; LIQUID CHROMATOGRAPHY; PROCEDURES; STANDARDS;

CHROMATOGRAPHY, LIQUID; CHROMATOGRAPHY, REVERSE-PHASE; DRUG CONTAMINATION; ETHYLAMINES; GINKGOLIDES; LACTONES; MESYLATES;

EID: 77950367939     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2010.01.019     Document Type: Article

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