Impact of 1.8-GHz radiofrequency radiation (RFR) on DNA damage and repair induced by doxorubicin in human B-cell lymphoblastoid cells

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 695, Issue 1-2, 2010, Pages 16-21

  Zhijian, Chen ^a   Xiaoxue, Li ^a   Yezhen, Lu ^a   Shijie, Chen ^a   Lifen, Jin ^a   Jianlin, Lou ^a   Deqiang, Lu ^a   Jiliang, He ^a  

^a ZHEJIANG UNIVERSITY   (China)

Author keywords

DNA damage; DNA repair; Doxorubicin; Radiofrequency radiation; Single cell gel electrophoresis (comet assay)

Indexed keywords

DOXORUBICIN; ANTINEOPLASTIC ANTIBIOTIC;

ARTICLE; COMET ASSAY; CONTROLLED STUDY; DAUDI CELL; DNA DAMAGE; DNA REPAIR; DOSE RESPONSE; HUMAN; HUMAN CELL; IN VITRO STUDY; PRIORITY JOURNAL; RADIATION EXPOSURE; RADIOFREQUENCY RADIATION; B LYMPHOCYTE; CELL CULTURE; DRUG EFFECT; PHYSIOLOGY;

ANTIBIOTICS, ANTINEOPLASTIC; B-LYMPHOCYTES; CELLS, CULTURED; COMET ASSAY; DNA DAMAGE; DNA REPAIR; DOSE-RESPONSE RELATIONSHIP, DRUG; DOXORUBICIN; HUMANS; RADIO WAVES;

EID: 77950365854     PISSN: 13835718     EISSN: 18793592     Source Type: Journal    
DOI: 10.1016/j.mrgentox.2009.10.001     Document Type: Article

References (35)

1. Carter S.K. Adriamycin-a review. J. Natl. Cancer Inst. 1975, 55:1265-1274.
2. Tewey K.M., Rowe T.C., Yang L., Halligan B.D., Liu L.F. Adriamycin-induced DNA damage mediated by mammalian DNA topoisomerase II. Science 1984, 226:466-468.
3. Burden D.A., Osheroff N. Mechanism of action of eukaryotic topoisomerase II and drugs targeted to the enzyme. Biochim. Biophys. Acta 1998, 1400:139-154.
4. Zeman S.M., Phillips D.R., Crothers D.M. Characterization of covalent adriamycin-DNA adducts. Proc. Natl. Acad. Sci. U.S.A. 1998, 95:11561-11565.
5. A. Dimarco, Adriamycin (Nsc-123127)-Mode and Mechanism of Action, Cancer Chemotherapy Reports Part 3 Program Information-Supplement 6 (1975) 91-106.
6. Cutts S.M., Phillips D.R. Use of oligonucleotides to define the site of interstrand cross-links induced by adriamycin. Nucleic Acids Res. 1995, 23:2450-2456.
7. Swift L.P., Rephaeli A., Nudelman A., Phillips D.R., Cutts S.M. Doxorubicin-DNA adducts induce a non-topoisomerase II-mediated form of cell death. Cancer Res. 2006, 66:4863-4871.
8. Au W.W., Butler M.A., Matney T.S., Loo T.L. Comparative structure-genotoxicity study of three aminoanthraquinone drugs and doxorubicin. Cancer Res. 1981, 41:376-379.
9. Marquardt H., Philips F.S., Sternberg S.S. Tumorigenicity in vivo and induction of malignant transformation and mutagenesis in cell cultures by adriamycin and daunomycin. Cancer Res. 1976, 36:2065-2069.
10. Heynick L.N., Johnston S.A., Mason P.A. Radio frequency electromagnetic fields: cancer, mutagenesis, and genotoxicity. Bioelectromagnetics 2003, (Suppl. (6)):S74-100.
11. Moulder J.E., Foster K.R., Erdreich L.S., McNamee J.P. Mobile phones, mobile phone base stations and cancer: a review. Int. J. Radiat. Biol. 2005, 81:189-203.
12. Verschaeve L. Genetic effects of radiofrequency radiation (RFR). Toxicol. Appl. Pharmacol. 2005, 207:336-341.
13. Maes A., Collier M., Verschaeve L. Cytogenetic effects of 900MHz (GSM) microwaves on human lymphocytes. Bioelectromagnetics 2001, 22:91-96.
14. Maes A., Collier M., Slaets D., Verschaeve L. 954MHz microwaves enhance the mutagenic properties of mitomycin C. Environ. Mol. Mutagen. 1996, 28:26-30.
15. Maes A., Collier M., VanGorp U., Vandoninck S., Verschaeve L. Cytogenetic effects of 935.2-MHz (GSM) microwaves alone and in combination with mitomycin C. Mutat. Res. 1997, 393:151-156.
16. Maes A., Collier M., Verschaeve L. Cytogenetic investigations on microwaves emitted by a 455.7MHz car phone. Folia. Biol. (Praha) 2000, 46:175-180.
17. Zhang M.B., He J.L., Jin L.F., Lu D.Q. Study of low-intensity 2450-MHz microwave exposure enhancing the genotoxic effects of mitomycin C using micronucleus test and comet assay in vitro. Biomed. Environ. Sci. 2002, 15:283-290.
18. Baohong W., Jiliang H., Lifen J., Deqiang L., Wei Z., Jianlin L., Hongping D. Studying the synergistic damage effects induced by 1.8GHz radiofrequency field radiation (RFR) with four chemical mutagens on human lymphocyte DNA using comet assay in vitro. Mutat. Res. 2005, 578:149-157.
19. Gos P., Eicher B., Kohli J., Heyer W.D. No mutagenic or recombinogenic effects of mobile phone fields at 900MHz detected in the yeast Saccharomyces cerevisiae. Bioelectromagnetics 2000, 21:515-523.
20. Duran G.E., Lau D.H., Lewis A.D., Kuhl J.S., Bammler T.K., Sikic B.I. Differential single- versus double-strand DNA breakage produced by doxorubicin and its morpholinyl analogues. Cancer Chemother. Pharmacol. 1996, 38:210-216.
21. Li Z.X., Wang T.T., Wu Y.T., Xu C.M., Dong M.Y., Sheng J.Z., Huang H.F. Adriamycin induces H2AX phosphorylation in human spermatozoa. Asian J. Androl. 2008, 10:749-757.
22. Salti G.I., Das Gupta T.K., Constantinou A.I. A novel use for the comet assay: detection of topoisomerase II inhibitors. Anticancer Res. 2000, 20:3189-3193.
23. Ahlbom A., Bergqvist U., Bernhardt J.H., Cesarini J.P., Court L.A., Grandolfo M., Hietanen M., McKinlay A.F., Repacholi M.H., Sliney D.H., Stolwijk J.A.J., Swicord M.L., Szabo L.D., Taki M., Tenforde T.S., Jammet H.P., Matthes R., Protectio I.C.N.R. Guidelines for limiting exposure to time-varying electric, magnetic, and electromagnetic fields (up to 300GHz). Health Phys. 1998, 74:494-522.
24. Valverde M., Rojas E. Environmental and occupational biomonitoring using the Comet assay. Mutat. Res. 2009, 681:93-109.
25. Zeng Q., Chen G., Weng Y., Wang L., Chiang H., Lu D., Xu Z. Effects of global system for mobile communications 1800MHz radiofrequency electromagnetic fields on gene and protein expression in MCF-7 cells. Proteomics 2006, 6:4732-4738.
26. Leszczynski D., Nylund R., Joenvaara S., Reivinen J. Applicability of discovery science approach to determine biological effects of mobile phone radiation. Proteomics 2004, 4:426-431.
27. Singh N.P., McCoy M.T., Tice R.R., Schneider E.L. A simple technique for quantitation of low levels of DNA damage in individual cells. Exp. Cell Res. 1988, 175:184-191.
28. Collins A.R., Oscoz A.A., Brunborg G., Gaivao I., Giovannelli L., Kruszewski M., Smith C.C., Stetina R. The comet assay: topical issues. Mutagenesis 2008, 23:143-151.
29. Baohong W., Lifen J., Lanjuan L., Jianlin L., Deqiang L., Wei Z., Jiliang H. Evaluating the combinative effects on human lymphocyte DNA damage induced by ultraviolet ray C plus 1.8GHz microwaves using comet assay in vitro. Toxicology 2007, 232:311-316.
30. Zhijian C., Xiaoxue L., Yezhen L., Deqiang L., Shijie C., Lifen J., Jianlin L., Jiliang H. Influence of 1.8-GHz (GSM) radiofrequency radiation (RFR) on DNA damage and repair induced by X-rays in human leukocytes in vitro. Mutat. Res. 2009, 677:100-104.
31. Spencer D.M., Bilardi R.A., Koch T.H., Post G.C., Nafie J.W., Kimura K., Cutts S.M., Phillips D.R. DNA repair in response to anthracycline-DNA adducts: a role for both homologous recombination and nucleotide excision repair. Mutat. Res. 2008, 638:110-121.
32. Muller I., Niethammer D., Bruchelt G. Anthracycline-derived chemotherapeutics in apoptosis and free radical cytotoxicity (Review). Int. J. Mol. Med. 1998, 1:491-494.
33. Collins A.R. The comet assay for DNA damage and repair: principles, applications, and limitations. Mol. Biotechnol. 2004, 26:249-261.
34. Christmann M., Tomicic M.T., Roos W.P., Kaina B. Mechanisms of human DNA repair: an update. Toxicology 2003, 193:3-34.
35. Binaschi M., Capranico G., De Isabella P., Mariani M., Supino R., Tinelli S., Zunino F. Comparison of DNA cleavage induced by etoposide and doxorubicin in two human small-cell lung cancer lines with different sensitivities to topoisomerase II inhibitors. Int. J. Cancer 1990, 45:347-352.