AKT controls human first trimester trophoblast cell sensitivity to FAS-mediated apoptosis by regulating XIAP expression

Biology of Reproduction

Volumn 82, Issue 1, 2010, Pages 146-152

  Straszewski Chavez, Shawn L ^a,c   Abrahams, Vikki M ^a   Aldo, Paula B ^a   Romero, Roberto ^b   Mor, Gil ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^c STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

AKT; Apoptosis; FAS; PIK3; Placenta; Pregnancy; Trophoblast; XIAP

Indexed keywords

CASPASE 3; FAS ANTIGEN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN KINASE B INHIBITOR; X LINKED INHIBITOR OF APOPTOSIS; 2 MORPHOLINO 8 PHENYLCHROMONE; 2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE; API 2; CHLORPROPAMIDE; CHROMONE DERIVATIVE; DRUG DERIVATIVE; FAS PROTEIN, HUMAN; MORPHOLINE DERIVATIVE; XIAP PROTEIN, HUMAN;

APOPTOSIS; ARTICLE; CELL SENSITIVITY; CELLULAR PARAMETERS; CONTROLLED STUDY; FEMALE; FIRST TRIMESTER PREGNANCY; HUMAN; HUMAN CELL; HUMAN TISSUE; INHIBITION KINETICS; MUTANT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; TROPHOBLAST; CELL LINE; DOWN REGULATION; DRUG ANTAGONISM; METABOLISM; PHOSPHORYLATION; PREGNANCY;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANTIGENS, CD95; APOPTOSIS; CASPASE 3; CELL LINE; CHLORPROPAMIDE; CHROMONES; DOWN-REGULATION; FEMALE; HUMANS; MORPHOLINES; PHOSPHORYLATION; PREGNANCY; PREGNANCY TRIMESTER, FIRST; PROTO-ONCOGENE PROTEINS C-AKT; TROPHOBLASTS; X-LINKED INHIBITOR OF APOPTOSIS PROTEIN;

EID: 77950350826     PISSN: 00063363     EISSN: 15297268     Source Type: Journal    
DOI: 10.1095/biolreprod.109.078972     Document Type: Article

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