Aromatase and in situ estrogen production in DCIS (ductal carcinoma in situ) of human breast

Journal of Steroid Biochemistry and Molecular Biology

Volumn 118, Issue 4-5, 2010, Pages 242-245

  Sasano, Hironobu ^a   Miki, Yasuhiro ^a   Shibuya, Rie ^a   Suzuki, Takashi ^a  

^a TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Aromatase; Atypical ductal hyperplasia; Breast; DCIS; Estrogens; Receptor

Indexed keywords

AROMATASE; ESTRADIOL; ESTROGEN; ESTROGEN RECEPTOR ALPHA; LETROZOLE; MESSENGER RNA; PLACEBO; TAMOXIFEN;

ANTINEOPLASTIC ACTIVITY; AROMATIZATION; BREAST CANCER; BREAST CARCINOGENESIS; BREAST HYPERPLASIA; CANCER GROWTH; CANCER TISSUE; CELL PROLIFERATION; CONFERENCE PAPER; ELECTROSPRAY MASS SPECTROMETRY; ENZYME LOCALIZATION; ESTROGEN ACTIVITY; ESTROGEN SYNTHESIS; GENE OVEREXPRESSION; HORMONE INHIBITION; HUMAN; IMMUNOHISTOCHEMISTRY; INTRADUCTAL CARCINOMA; LASER CAPTURE MICRODISSECTION; LIQUID CHROMATOGRAPHY; NONHUMAN; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STROMA CELL; TANDEM MASS SPECTROMETRY; TISSUE LEVEL; ARTICLE; ENZYMOLOGY; GENE EXPRESSION REGULATION; METABOLISM; PAGET NIPPLE DISEASE; PATHOLOGY;

AROMATASE; CARCINOMA, DUCTAL; CARCINOMA, DUCTAL, BREAST; ESTROGENS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS;

EID: 77950348421     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2009.09.008     Document Type: Conference Paper

References (28)

1. F.A. Tavassoli, H. Hoefler, J. Rosai, R. Holland, I.O. Ellis, S. Schnitt, W. Boecker, S.H. Heywang-Kobrunner, F. Moinfar, S.R. Lakhani, in: F.A. Tavassoli, P. Devillee (Eds.), Intraductal Proliferative Lesions in World Health Organization Classification of the Tumors: Pathology and Genetics. Tumours of the Breast and Female Genital Organs, 2003, pp. 63-73.
2. W.D. Dupont, D.L. Page, Risk factors for breast cancer in women with proliferative disease, N. Engl. J. Med. 312 (1985) 146-151.
3. M.G. FitzGerald, D.E. Henson, R.V. Hutter, Benign breast changes and the risk for subsequent beast cancer: an update of the 1985 consensus statement. Cancer Committee of the College of American Pathologists, Arch. Pathol. Lab. Med. 122 (1998) 1053-1055.
4. K. Mokbel, Treatment of ductal carcinoma in situ of the breast: review of recent advances and future prospects, Int. J. Fertil. Womens Med. 48 (2003) 217-225.
5. V.L. Ernster, J. Barclay, K. Kerlikowske, H. Wilkie, R. Ballard-Barbash, Mortality among women with ductal carcinoma in situ of the breast in the populationbased surveillance, epidemiology and end results program, Arch. Intern. Med. 160 (2000) 953-958.
6. D.C. Allred, S.K. Mohsin, S.A. Fuqua, Histological and biological evolution of human premalignant breast disease, Endocr. Relat. Cancer 8 (2001) 47-61.
7. M. Iqbal, M.P. Davies, B.S. Shoker, C. Jarvis, D.R. Sibson, J.P. Sloane, Subgroups of non-atypical hyperplasia of breast defined by proliferation of estrogen receptor positive cells, J. Pathol. 193 (2001) 323-338.
8. B.S. Shoker, C. Jarvis, R.B. Clarke, E. Anderson, C. Munro, M.P. Davis, D.R. Sibson, J.P. Sloan, Abnormal regulation of oestrogen receptor in benign breast lesions, J. Clin. Pathol. 53 (2000) 778-783.
9. J. Kepple, R.S. Henry-Tillman, V.S. Klimberg, The receptor expression pattern in ductal carcinoma in situ predicts recurrence, Am. J. Surg. 192 (2006) 68-71.
10. T. Baqai, S. Shousha, Oestrogen receptor negativity as a marker for high-grade ductal carcinoma in situ of the breast, Histopathology 42 (2003) 440-447.
11. A.G. Selim, G. El-Ayat, C.A. Wells, Androgen receptor expression in ductal carcinoma in situ of the breast: relation to oestrogen and progesterone receptors, J. Clin. Pathol. 55 (2002) 14-16. (Pubitemid 34081674)
12. F. Moinfar, M. Okcu, O. Tsybrovskyy, Androgen receptors frequently are expressed in breast carcinomas: potential relevance to new therapeutic strategies, Cancer 98 (2003) 703-711.
13. N.L. Barnes, G.P. Boland, A. Davenport, W.F. Knox, N.J. Bundred, Relationship between hormone receptor status and tumour size, grade and comedo necrosis in ductal carcinoma in situ, Br. J. Surg. 92 (2005) 429-434.
14. A.J. Karayiannakis, E.A. Bastounis, E.B. Chatzigianni, G.G. Makri, D. Alexiou, P. Laramanakos, Immunohistochemical detection of oestrogen receptors in dictal carcinoma in situ of the breast, Eur. J. Surg. Oncol. 22 (1996) 578-582.
15. G.H. Sakorafas, D.R. Farley, G. Peros, Recent advances and current controversies in the management of DCIS of the breast, Cancer Treat. Rev. 34 (6) (2008) 483-497.
16. R. Namba, L.J. Young, J.E. Maglione, Selective estrogen receptor modulators inhibit growth and progression of premalignant lesions in a mouse model of ductal carcinoma in situ, Breast Cancer Res. 7 (2005) 881-889.
17. B.K. Dunn, D.L. Wickerham, L.G. Ford, Prevention of hormone-related cancers: breast cancer, J. Clin. Oncol. 23 (2005) 357-367.
18. J. Cuzick, Treatment of DCIS-results from clinical trials, Surg. Oncol. 12 (2003) 213-219.
19. R. Shibuya, T. Suzuki, Y. Miki, K. Yoshida, T. Moriya, K. Ono, J.I. Akahira, T. Ishida, H. Hirakawa, D.B. Evans, H. Sasano, Intratumoral concentration of sex steroids and expression of sex steroid-producing enzymes in ductal carcinoma in situ of human breast, Endocr. Relat. Cancer 15 (2008) 113-124.
20. T. Suzuki, Y. Miki, J. Akahira, T. Moriya, N. Ohuchi, H. Sasano, Aromatase in human breast carcinoma as a key regulator of intratumoral sex steroid concentrations, Endocr. J. 55 (2008) 455-463.
21. H. Sasano, T. Suzuki, Y. Miki, T. Moriya, Intracrinology of estrogens and androgens in breast carcinoma, J. Steroid Biochem. Mol. Biol. 108 (2007) 181-185.
22. Y. Miki, T. Suzuki, C. Tazawa, Y. Yamaguchi, K. Kitada, S. Honma, T. Moriya, H. Hirakawa, D.B. Evans, S. Hayashi, N. Ohuchi, H. Sasano, Aromatase localization in human breast cancer tissues: possible interactions between intratumoral stromal and parenchymal cells, Cancer Res. 67 (2007) 3945-3954.
23. T. Suzuki, Y. Miki, T. Moriya, J. Akahira, H. Hirakawa, N. Ohuchi, H. Sasano, In situ production of sex steroids in human breast carcinoma, Med. Mol. Morphol. 40 (2007) 121-127.
24. I.E. Smith, S. Chua, Medical treatment of early breast cancer. II. Endocrine therapy, Br. Med. J. 332 (2006) 101-103.
25. P.E. Goss, J.N. Ingle, S. Martino, N.J. Robert, H.B. Muss, M.J. Piccart, M. Castiglione, D. Tu, L.E. SHephert, K.I. Prichard, R.B. Livingston, N.E. Davidson, L. Norton, E.A. Perez, J.S. Abtrams, P. Therasse, M.J. Palmer, J.L. Pater, A randomized trial of letrozole in postmenopausal women after five years of tamoxifen therapy for early stage breast cancer, N. Engl. J. Med. 349 (2003) 1793-1802.
26. Z. Zhang, H. Yamashita, T. Toyama, Semi-quantitative immunohistochemical analysis of aromatase expression in ductal carcinoma in situ of the breast, Breast Cancer Res. Treat. 74 (2002) 47-53.
27. V.M. Oliveira, S. Piato, M.A. Silva, Correlation of cyclooxygenase-2 and aromatase immunohistochemical expression in invasive ductal carcinoma, ductal carcinoma in situ, and adjacent normal epithelium, Breast Cancer Res. Treat. 95 (2006) 235-241.
28. H. Sasano, T.J. Anderson, S.G. Silverberg, R.J. Santen, M. Conway, D.P. Edwards, A. Krause, A.S. Bhatnagar, D.B. Evans, W.R. Miller, The validation of new aromatase monoclonal antibodies for immunohistochemistry-a correlation with biochemical activities in 46 cases of breast cancer, J. Steroid Biochem.Mol. Biol. 95 (2005) 35-39.