L-carnitine supplementation and EPO requirement in children on chronic hemodialysis

Pediatric Nephrology

Volumn 25, Issue 3, 2010, Pages 557-560

  Aoun, Bilal ^a   Bérard, Etienne ^b   Vitkevic, Renata ^a   Dehée, Axelle ^a   Bensman, Albert ^a   Ulinski, Tim ^a  

^a ARMAND TROUSSEAU HOSPITAL   (France)

^b CENTRE HOSPITALIER UNIVERSITAIRE DE NICE   (France)

Author keywords

Anemia; Erythrocyte; Erythropoetin; Hemodialysis; L Carnitine; Uremia

Indexed keywords

CARNITINE; ERYTHROPOIETIN; HEMOGLOBIN; NOVEL ERYTHROPOIESIS STIMULATING PROTEIN; RECOMBINANT ERYTHROPOIETIN;

ADOLESCENT; AMINO ACID BLOOD LEVEL; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; DRUG DOSE INCREASE; DRUG DOSE REDUCTION; DRUG EFFICACY; FEMALE; HEMODIALYSIS; HEMOGLOBIN BLOOD LEVEL; HUMAN; IRON BLOOD LEVEL; IRON THERAPY; MALE; NUTRITIONAL STATUS; PRIORITY JOURNAL; SUPPLEMENTATION; TREATMENT DURATION; BLOOD; CHILD; CHRONIC KIDNEY FAILURE; INTRAVENOUS DRUG ADMINISTRATION; METABOLISM; PROSPECTIVE STUDY; RENAL REPLACEMENT THERAPY; TREATMENT OUTCOME;

ADOLESCENT; CARNITINE; CHILD; ERYTHROPOIETIN, RECOMBINANT; FEMALE; HEMOGLOBINS; HUMANS; INJECTIONS, INTRAVENOUS; KIDNEY FAILURE, CHRONIC; MALE; PROSPECTIVE STUDIES; RENAL DIALYSIS; TREATMENT OUTCOME;

EID: 77950345304     PISSN: 0931041X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00467-009-1276-9     Document Type: Article

References (11)

1. Siliprandi N, Di Lisa F, Menabo R (1990) Clinical use of carnitine. Past, present and future. Adv Exp Med Biol 272:175-181
2. Berard E, Barrillon D, Iordache A, Bayle J, Cassuto-Viguier E (1994) Low dose of L-carnitine impairs membrane fragility of erythrocytes in hemodialysis patients. Nephron 68:145 (Pubitemid 24251207)
3. Cheng JT, Kahn T, Kaji DM (1984) Mechanism of alteration of sodium potassium pump of erythrocytes from patients with chronic renal failure. J Clin Invest 74:1811-1820 (Pubitemid 15214095)
4. Evans AM, Faull R, Fornasini G, Lemanowicz EF, Longo A, Pace S, Nation RL (2000) Pharmacokinetics of L-carnitine in patients with end-stage renal disease undergoing long-term hemodialysis. Clin Pharmacol Ther 68:238-249
5. Debska S, Kawecka A, Wojnarowski K, Prajs J, Malgorzewicz S, Kunicka D, Zdrojewski Z, Walysiak S, Lipinski J, Rutkowski B (2000) Correlation between plasma carnitine, muscle carnitine and glycogen levels in maintenance hemodialysis patients. Int J Artif Organs 23:90-96 (Pubitemid 30192762)
6. Sakurauchi Y, Matsumoto Y, Shinzato T, Takai I, Nakamura Y, Sato M, Nakai S,MiwaM,Morita H,Miwa T, Amano I, Maeda K (1998) Effects of L-carnitine supplementation on muscular symptoms in hemodialyzed patients. Am J Kidney Dis 32:258-264 (Pubitemid 28364329)
7. Schreiber B (2005) Levocarnitine and dialysis: A review. Nutr Clin Prac 20:218-243 (Pubitemid 43093069)
8. Verrina E, Caruso U, Calevo MG, Emma F, Sorino P, De Palo T, Lavoratti G, Turrini Dertenois L, Cassanello M, Cerone R, Perfumo F (2007) Effect of carnitine supplementation on lipid profile and anemia in children on chronic dialysis. Pediatr Nephrol 22:727-733 (Pubitemid 46691531)
9. Arduini A, Bonomini M, Savica V, Amato A, Zammit V (2008) Carnitine in metabolic disease: Potential for pharmacological intervention. Pharmacol Ther 120:149-156
10. Calo LA, Davis PA, Pagnin E, Bertipaglia L, Naso A, Piccoli A, Corradini R, Spinello M, Savica V, Dalla Libera L (2008) Carnitine-mediated improved response to erythropoietin involves induction of haem oxygenase-1: Studies in humans and in an animal model. Nephrol Dial Transplant 23:890-895 (Pubitemid 351767567)
11. Calo LA, Pagnin E, Davis PA, Semplicini A, Nicolai R, Calvani M, Pessina AC (2006) Antioxidant effect of Lcarnitine and its short chain esters: Relevance for the protection from oxidative stress related cardiovascular damage. Int J Cardiol 107:54-60 (Pubitemid 41767518)