Statin therapy shortens QTc, QTcd, and improves cardiac function in patients with chronic heart failure

International Journal of Cardiology

Volumn 140, Issue 2, 2010, Pages 255-257

  Xie, Rui qin ^a   Cui, Wei ^a   Liu, Fan ^a   Yang, Chao ^a   Pei, Wei na ^a   Lu, Jing chao ^a  

^a HEBEI MEDICAL UNIVERSITY   (China)

Author keywords

Atorvastatin; CAD; Cardiac function; CHF; QTcd

Indexed keywords

ATORVASTATIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LOW DENSITY LIPOPROTEIN CHOLESTEROL;

ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; CORONARY ARTERY DISEASE; DRUG MECHANISM; HEART FAILURE; HEART LEFT VENTRICLE EJECTION FRACTION; HUMAN; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; QT DISPERSION; QT INTERVAL;

CHRONIC DISEASE; ELECTROCARDIOGRAPHY; HEART FAILURE; HEPTANOIC ACIDS; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; LONG QT SYNDROME; PYRROLES; TREATMENT OUTCOME; VENTRICULAR FUNCTION, LEFT;

EID: 77950339319     PISSN: 01675273     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijcard.2008.11.030     Document Type: Article

References (8)

1. Vrtovec B., Stojanovic I., Radovancevic R., Yazdanbakhsh A.P., Thomas C.D., and Radovancevic B. Statin-associated QTc interval shortening as prognostic indicator in heart transplant recipients. J Heart Lung Transplant 25 (2006) 234-236
2. Vrtovec B., Okrajsek R., Golicnik A., Ferjan M., Starc V., and Radovancevic B. Atorvastatin therapy increases heart rate variability, decreases QT variability, and shortens QTc interval duration in patients with advanced chronic heart failure. J Card Fail 11 (2005) 684-690
3. Node K., Fujita M., Kitakaze M., Hori M., and Liao J.K. Short-term statin therapy improves cardiac function and symptoms in patients with idiopathic dilated cardiomyopathy. Circulation 108 (2003) 839-843
4. Abraham S.S., Osorio J.C., Homma S., et al. Simvastatin preserves cardiac function in genetically determined cardiomyopathy. J Cardiovasc Pharmacol 43 (2004) 454-461
5. Corovic N., Durakovic Z., and Misigoj-Durakovic M. Dispersion of the corrected QT and JT interval in the electrocardiogram of alcoholic patients. Alcohol Clin Exp Res 30 (2006) 150-154
6. Go A.S., Lee W.Y., Yang J., Lo J.C., and Gurwitz J.H. Statin therapy and risks for death and hospitalization in chronic heart failure. JAMA 296 (2006) 2105-2111
7. Horwich T.B., MacLellan W.R., and Fonarow G.C. Statin therapy is associated with improved survival in ischemic and non-ischemic heart failure. J Am Coll Cardiol 43 (2004) 642-648
8. Kjekshus J., Apetrei E., Barrios V., et al. Rosuvastatin in older patients with systolic heart failure. N Engl J Med 357 (2007) 2248-2261