Where metabolism meets oncogenesis: Another false lead?

The Lancet Oncology

Volumn 11, Issue 4, 2010, Pages 309-310

  Grossman, Ashley B ^a  

^a ST BARTHOLOMEW S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2 HYDROXYGLUTARIC ACID; FLAVINE ADENINE NUCLEOTIDE; ISOCITRATE DEHYDROGENASE; SUCCINATE DEHYDROGENASE;

AMINO ACID SUBSTITUTION; CARCINOGENESIS; CITRIC ACID CYCLE; GENE DELETION; GENE MUTATION; GENETIC SCREENING; HEAD AND NECK CANCER; HUMAN; HYPOXIA; LETTER; ONCOGENE; PARAGANGLIOMA; PEDIGREE ANALYSIS; PHEOCHROMOCYTOMA; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE;

CITRIC ACID CYCLE; ELECTRON TRANSPORT COMPLEX II; HEAD AND NECK NEOPLASMS; HUMANS; MUTATION; NETHERLANDS; PARAGANGLIOMA; PHEOCHROMOCYTOMA; PROTEIN SUBUNITS; SPAIN; SUCCINATE DEHYDROGENASE;

EID: 77950338619     PISSN: 14702045     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1470-2045(10)70003-6     Document Type: Letter

References (5)

1. Cascon A, Lopez-Jimenez E, Landa I, et al. Rationalization of genetic testing in patients with apparently sporadic pheochromocytoma/paraganglioma. Horm Metab Res 2009, 41:672-675.
2. Hao HX, Khalimonchuk O, Schraders M, et al. SDH5, a gene required for flavination of succinate dehydrogenase, is mutated in paraganglioma. Science 2009, 325:1139-1142.
3. Bayley J-P, Kunst HPM, Cascon A, et al. SDHAF2 mutations in familial and sporadic paraganglioma and pheochromocytoma. Lancet Oncol 2010, published online Jan 12. 10.1016/S1470-2045(10)70007-3.
4. Gaal J, Burnichon N, Korperschoek E, et al. Isocitrate dehydrogenase mutations are rare in pheochromocytomas and paragangliomas. J Clin Endocrinol Metab 2009, published online Nov 13. 10.1210/jc.2009-2170.
5. Dang L, White DW, Gross S, et al. Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature 2009, 462:739-744.