In vitro activity of anti-leishmanial drugs against Leishmania donovani is host cell dependent

Journal of Antimicrobial Chemotherapy

Volumn 65, Issue 3, 2010, Pages 508-511

  Seifert, Karin ^a   Escobar, Patricia ^b   Croft, Simon L ^a  

^a LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^b UNIVERSIDAD INDUSTRIAL DE SANTANDER   (Colombia)

Author keywords

Biological activity; Leishmaniasis; Macrophages

Indexed keywords

AMPHOTERICIN B DEOXYCHOLATE; AMPHOTERICIN B LIPID COMPLEX; MILTEFOSINE; PAROMOMYCIN; STIBOGLUCONATE SODIUM;

AMASTIGOTE; ANIMAL CELL; ANTILEISHMANIAL ACTIVITY; ARTICLE; BONE MARROW CELL; CONTROLLED STUDY; DRUG ACTIVITY; FEMALE; HOST CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; LEISHMANIA DONOVANI; MACROPHAGE; MOUSE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PERITONEUM MACROPHAGE; TH1 CELL;

ANIMALS; ANTIPROTOZOAL AGENTS; CELL LINE; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; LEISHMANIA DONOVANI; MACROPHAGES; MICE; MICE, INBRED BALB C;

EID: 77950330640     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dkp500     Document Type: Article

References (10)

1. Alvar J, Croft S, Olliaro P. Chemotherapy in the treatment and control of leishmaniasis. Adv Parasitol 2006; 61: 223-74.
2. Kumar D, Kulshrestha A, Singh R et al. In vitro susceptibility of field isolates of Leishmania donovani to miltefosine and amphotericin B: correlation with sodium antimony gluconate susceptibility and implications for treatment in areas of endemicity. Antimicrob Agents Chemother 2009; 53: 835-8.
3. Neal RA, Croft SL. An in-vitro system for determining the activity of compounds against the intracellular amastigote form of Leishmania donovani. J Antimicrob Chemother 1984; 14: 463-75.
4. Berman JD, Wyler DJ. An in vitro model for investigation of chemotherapeutic agents in leishmaniasis. J Infect Dis 1980; 142: 83-6.
5. Gebre-Hiwot A, Tadesse G, Croft SL et al. An in vitro model for screening antileishmanial drugs: the human leukaemia monocyte cell line, THP-1. Acta Trop 1992; 51: 237-45.
6. Martinez S, Looker DL, Marr JJ. A tissue culture system for the growth of several species of Leishmania: growth kinetics and drug sensitivities. Am J Trop Med Hyg 1988; 38: 304-7.
7. Seifert K, Croft SL. Invitro and invivo interactions betweenmiltefosine and other antileishmanial drugs. Antimicrob Agents Chemother 2006; 50: 73-9.
8. Nicoletti S, Seifert K, Gilbert IH. N-(2-hydroxypropyl)methacrylamide-amphotericin B (HPMA-AmB) copolymer conjugates as antileishmanial agents. Int J Antimicrob Agents 2009; 33: 441-8.
9. Crocker PR, Davies EV, Blackwell JM. Variable expression of the murine natural resistance gene Lsh in different macrophage populations infected in vitro with Leishmania donovani. Parasite Immunol 1987; 9: 705-19.
10. Maia C, Rolao N, Nunes M et al. Infectivity of five different types of macrophages by Leishmania infantum. Acta Trop 2007; 103: 150-5.