Genetic variants of STAT4 associated with rheumatoid arthritis in persons of Asian and European ancestry do not replicate in African Americans

Annals of the Rheumatic Diseases

Volumn 69, Issue 4, 2010, Pages 625-626

  Kelley, James M ^a   Hughes, Laura B ^a   Malik, Ashima ^a   Danila, Maria I ^a   Edberg, Yuanqing ^a   Alarcón, Graciela S ^a   Conn, Doyt L ^b   Jonas, Beth L ^c   Callahan, Leigh F ^c   Smith, Edwin A ^d   Brasington, Richard D ^e   Edberg, Jeffrey C ^a   Kimberly, Robert P ^a   Moreland, Larry W ^a,f   Bridges Jr , S Louis ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b EMORY UNIVERSITY   (United States)

^c UNIVERSITY OF NORTH CAROLINA   (United States)

^d MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^e WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

STAT4 PROTEIN;

AFRICAN AMERICAN; ASIA; EUROPE; GENE LINKAGE DISEQUILIBRIUM; GENETIC VARIABILITY; GENOTYPE; HUMAN; LETTER; PRIORITY JOURNAL; RACE DIFFERENCE; RHEUMATOID ARTHRITIS; SINGLE NUCLEOTIDE POLYMORPHISM;

AFRICAN AMERICANS; ARTHRITIS, RHEUMATOID; ASIAN CONTINENTAL ANCESTRY GROUP; EUROPEAN CONTINENTAL ANCESTRY GROUP; GENETIC PREDISPOSITION TO DISEASE; HUMANS; POLYMORPHISM, SINGLE NUCLEOTIDE; STAT4 TRANSCRIPTION FACTOR;

EID: 77950313330     PISSN: 00034967     EISSN: 14682060     Source Type: Journal    
DOI: 10.1136/ard.2009.113183     Document Type: Letter

References (9)

1. Remmers EF, Plenge RM, Lee AT, et al. STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus. N Engl J Med 2007;357:977-986
2. Kelley J, Dean C, Ross S. Root growth during molar eruption in extant great apes. Front Oral Biol 2009;13:128-133
3. Palomino-Morales RJ, Rojas-Villarraga A, González CI, et al. STAT4 but not TRAF1/C5 variants influence the risk of developing rheumatoid arthritis and systemic lupus erythematosus in Colombians. Genes Immun 2008;9:379-382
4. Zervou MI, Mamoulakis D, Panierakis C, et al. STAT4: a risk factor for type 1 diabetes? Hum Immunol 2008;69:647-650
5. Orozco G, Alizadeh BZ, Delgado-Vega AM, et al. Association of STAT4 with rheumatoid arthritis: a replication study in three European populations. Arthritis Rheum 2008;58:1974-1980
6. Martínez A, Varadé J, Márquez A, et al. Association of the STAT4 gene with increased susceptibility for some immune-mediated diseases. Arthritis Rheum 2008;58:2598-2602
7. Kobayashi S, Ikari K, Kaneko H, et al. Association of STAT4 with susceptibility to rheumatoid arthritis and systemic lupus erythematosus in the Japanese population. Arthritis Rheum 2008;58:1940-1946
8. Lee HS, Remmers EF, Le JM, et al. Association of STAT4 with rheumatoid arthritis in the Korean population. Mol Med 2007;13:455-460
9. Barton A, Thomson W, Ke X, et al, Wellcome Trust Case Control Consortium; YEAR consortium. Re-evaluation of putative rheumatoid arthritis susceptibility genes in the post-genome wide association study era and hypothesis of a key pathway underlying susceptibility. Hum Mol Genet 2008;17:2274-2279