Cleistenolide and cleistodienol: Novel bioactive constituents of Cleistochlamys kirkii

Natural Product Communications

Volumn 2, Issue 7, 2007, Pages 737-741

  Samwel, Stephen ^a   Mdachi, Stephen J M ^a   Nkunya, Mayunga H H ^a   Irungu, Beatrice N ^a   Moshi, Mainen J ^b   Moulton, Brian ^c   Luisi, Brian S ^c  

^a UNIVERSITY OF DAR ES SALAAM   (Tanzania)

^b MUHIMBILI UNIVERSITY OF HEALTH AND ALLIED SCIENCES   (Tanzania)

^c BROWN UNIVERSITY   (United States)

Author keywords

Annonaceae; Antimicrobial; Cleistenolide; Cleistochlamys kirkii; Cleistodienol; Cytotoxicity; Heptenolides

Indexed keywords

EID: 77950302097     PISSN: 1934578X     EISSN: 15559475     Source Type: Journal    
DOI: 10.1177/1934578x0700200706     Document Type: Article

References (23)

1. Nkunya MHH. (2005) Unusual metabolites from some Tanzanian indigenous plant species. Pure and Applied Chemistry, 77, 1943-1955.
2. Nkunya MHH, Weenen H, Koyi NJ, Thijs L, Zwanenburg B. (1987) Cyclohexene epoxides, (+)-pandoxide, (+)-β-senepoxide and (-)-pipoxide, from Uvaria pandensis. Phytochemistry, 26, 2563-2565.
3. Nkunya MHH, Weenen H, Bray DH, Mgani QA, Mwasumbi LB. (1991) Antimalarial activity of Tanzanian plants and their active constituents: The genus Uvaria. Planta Medica, 57, 341-343.
4. Weenen H, Nkunya MHH, Mgani QA, Achenbach H, Posthumus MA, Waibel R. (1991) Lucidene, a bis(benzopyranyl) sesquiterpene from Uvaria lucida ssp. lucida. Journal of Organic Chemistry, 56, 5865-5867.
5. Freiburghaus F, Jonker SA, Nkunya MHH, Mwasumbi LB, Brun R. (1997) In vitro trypanocidal activity of some rare Tanzanian medicinal plants. Acta Tropica, 67, 181-185.
6. Sung'hwa F. Mgina CA, Jonker SA, Nkunya MHH, Waibel R, Achenbach H. (1999) Ophyrepetalin and other annonaceous acetogenins from Ophrypetalum odoratum. Natural Product Letters, 13, 195-202.
7. Nkunya MHH, Makangara JJ, Jonker SA. (2004) Prenylindoles from Tanzanian Monodora and Isolona Species. Natural Product Research, 18, 253-258.
8. Nkunya MHH, Jonker SA, Wachira SW, Kihampa C. (2004) (±)- Schefflone: A trimeric monoterpenoid from the root bark of Uvaria scheffleri. Phytochemistry, 65, 399-404.
9. Makangara JJ, Henry L, Jonker SA, Nkunya MHH. (2004) The caulindoles: Dimeric prenylindoles from Isolona cauliflora. Phytochemistry, 65, 227-232.
10. Verdcourt B. (1971) Flora of Tropical East Africa-Annonaceae, Crown Agents, London, pp 30, 124.
11. Verzar R, Petri G. (1987) Medicinal plants in Mozambique and their popular use. Journal of Ethnopharmacology, 19, 67-80.
12. Jung JH, Pammangura C, Chaichantipyuth C, Patarapanich C, McLaughlin JL. (1990) Bioactive constituents of Melodorum fruclicosum. Phytochemistry, 29, 1667-1670.
13. Jung JH, Chang CJ, McLaughlin JL, Pumangura S, Chaichantipyuth C, Patarapanich PE. (1991) Additional bioactive heptenes from Melodorum fruticosum. Journal of Natural Products, 54, 500-505.
14. Tuchida P, Udchachon J, Reutrakul V, Santisuk T, Taylor WC, Farnsworth NR, Pezzuto JM, Kinghorn AD. (1991) Bioactive butenolides from Melodorum fruticosum. Phytochemistry, 30, 2685-2689.
15. Shem CC, Chou SC, Chou CJ, Ho LK. (1996) Total synthesis of acetylmelodorinol. Tetrahedron Asymmetry, 7, 3141-3146.
16. Manat P, Patoomratana T, Pornchai P, Attasit L, Rentrakal V. (1999) Total synthesis of (S-(+)-melodorinol and (S)-(+)- acetylmelodorinol. Heterocycles, 51, 795-802.
17. Kodpinid M Sadavongvivad C, Thebtaranonth C, Thebtaranonth Y. (1983) Structures of β-senepoxide, tingtanoxide and their diene precursors. Constituentes of Uvaria ferruginea. Tetrahedron Letters, 24, 2019-2022.
18. Lasswell WL, Hufford CD. (1977) Cytotoxic C-benzylated flavonoids from Uvaria chamae. Journal of Organic Chemistry, 42, 1295-1296.
19. Hufford CD, Lasswell WL. (1978) Antimicrobial activities of constituents of Uvaria chamae. Lloydia, 41, 156-160.
20. nd Ed, Academic Press, London, pp 102-104.
21. Meyer BN, Ferrigini RN, Jacobsen LB, Nichoilas DE, McLaughlin JL. (1982) Brine shrimp test: A convenient general bioassay for active plant constituents. Planta Medica, 45, 31-34.
22. Stahl E. (1969) Thinlayer chromatography, a laboratory handbook, Springer-Verlag, New York, p. 857.
23. Moshi MJ, Joseph CC, Innocent E, Nkunya MHH. (2004) In-vitro antibacterial and antifungal activity of extracts and compounds from Uvaria scheffleri. Pharmaceutical Biology, 42, 269-273.