Long-term efficacy and safety of infliximab plus methotrexate for the treatment of polyarticular-course juvenile rheumatoid arthritis: Findings from an open-label treatment extension

Annals of the Rheumatic Diseases

Volumn 69, Issue 4, 2010, Pages 718-722

  Ruperto, Nicolino ^a   Lovell, Daniel J ^b   Cuttica, Ruben ^c   Woo, Patricia ^d   Meiorin, Silvia ^e   Wouters, Carine ^f   Silverman, Earl D ^g   Balogh, Zsolt ^h   Henrickson, Michael ⁱ   Davidson, Joyce ^j   Foeldvari, Ivan ^k   Imundo, Lisa ^l   Simonini, Gabriele ^m   Oppermann, Joachim ⁿ   Xu, Stephen ^o   Shen, Yaung Kaung ^o   Visvanathan, Sudha ^o   Fasanmade, Adedigbo ^o   Mendelsohn, Alan ^o   Martini, Alberto ^a,p   Giannini, Edward H ^b   more..

^a G GASLINI INSTITUTE   (Italy)

^b CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^c HOSPITAL GENERAL DE NIÑOS PEDRO DE ELIZALDE   (Argentina)

^d GREAT ORMOND STREET HOSPITAL   (United Kingdom)

^e HOSPITAL DE NIÑOS RICARDO GUTIÉRREZ   (Argentina)

^f UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^g HOSPITAL FOR SICK CHILDREN   (Canada)

^h NATIONAL INSTITUTE OF RHEUMATOLOGY AND PHYSIOTHERAPY   (Hungary)

ⁱ Children's Hospital Oklahoma City   (United States)

^j ROYAL HOSPITAL FOR SICK CHILDREN   (United Kingdom)

^k Hamburger Zentrum fur Kinder und Jugendrheumatologie   (Germany)

^l New York Presbyterian Hospital Columbia University Medical Center   (United States)

^m UNIVERSITY OF FLORENCE   (Italy)

ⁿ CARL THIEM KLINIKUM   (Germany)

^o Centocor Research and Development Inc   (United States)

^p UNIVERSITY OF GENOA   (Italy)

more..

Author keywords

[No Author keywords available]

Indexed keywords

INFLIXIMAB; METHOTREXATE; PLACEBO;

ANAPHYLAXIS; ARTICLE; BRONCHITIS; CHILL; CLINICAL ASSESSMENT; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG FEVER; DRUG INDUCED DISEASE; DRUG INDUCED HEADACHE; DRUG SAFETY; DRUG TOLERABILITY; DRUG WITHDRAWAL; HUMAN; IMMUNOGENICITY; INFECTION; INFUSION SYNDROME; JUVENILE RHEUMATOID ARTHRITIS; LONG TERM CARE; MAJOR CLINICAL STUDY; MULTICENTER STUDY; PHARYNGITIS; PHASE 3 CLINICAL TRIAL; PNEUMONIA; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RHINITIS; TREATMENT RESPONSE; UPPER RESPIRATORY TRACT INFECTION; URTICARIA; UVEITIS; VOMITING;

ADOLESCENT; ANTIBODIES, MONOCLONAL; ANTIRHEUMATIC AGENTS; ARTHRITIS, JUVENILE RHEUMATOID; CHILD; CHILD, PRESCHOOL; DRUG ADMINISTRATION SCHEDULE; DRUG THERAPY, COMBINATION; EPIDEMIOLOGIC METHODS; HUMANS; METHOTREXATE; TREATMENT OUTCOME;

EID: 77950301852     PISSN: 00034967     EISSN: 14682060     Source Type: Journal    
DOI: 10.1136/ard.2009.100354     Document Type: Article

References (15)

1. Ravelli A, Martini A. Juvenile idiopathic arthritis. Lancet 2007;369:767-778
2. Giannini EH, Brewer EJ, Kuzmina N, et al. Methotrexate in resistant juvenile rheumatoid arthritis. Results of the U.S.A.-U.S.S.R. double-blind, placebo-controlled trial. The Pediatric Rheumatology Collaborative Study Group and The Cooperative Children's Study Group. N Engl J Med 1992;326:1043-1049
3. Ruperto N, Murray KJ, Gerloni V, et al. A randomized trial of parenteral methotrexate comparing an intermediate dose with a higher dose in children with juvenile idiopathic arthritis who failed to respond to standard doses of methotrexate. Arthritis Rheum 2004;50:2191-2201
4. Lovell DJ, Giannini EH, Reiff A, et al. Etanercept in children with polyarticular juvenile rheumatoid arthritis. Pediatric Rheumatology Collaborative Study Group. N Engl J Med 2000;342:763-769
5. Ruperto N, Lovell DJ, Cuttica R, et al. A randomized, placebo-controlled trial of infliximab plus methotrexate for the treatment of polyarticular-course juvenile rheumatoid arthritis. Arthritis Rheum 2007;56:3096-3106
6. Ruperto N, Lovell DJ, Quartier P, et al. Abatacept in children with juvenile idiopathic arthritis: a randomised, double-blind, placebo-controlled withdrawal trial. Lancet 2008;372:383-391
7. Lovell DJ, Ruperto N, Goodman S, et al. Adalimumab with or without methotrexate in juvenile rheumatoid arthritis. N Engl J Med 2008;359:810-820
8. Cassidy JT, Levinson JE, Bass JC, et al. A study of classification criteria for a diagnosis of juvenile rheumatoid arthritis. Arthritis Rheum 1986;29:274-281
9. American Thoracic Society. Targeted tuberculin testing and treatment of latent tuberculosis infection. Am J Respir Crit Care Med 2000;161:S221-47.
10. Giannini EH, Ruperto N, Ravelli A, et al. Preliminary definition of improvement in juvenile arthritis. Arthritis Rheum 1997;40:1202-1209
11. Singh G, Athreya BH, Fries JF, et al. Measurement of health status in children with juvenile rheumatoid arthritis. Arthritis Rheum 1994;37:1761-1769
12. Ruperto N, Ravelli A, Pistorio A, et al. Cross-cultural adaptation and psychometric evaluation of the Childhood Health Assessment Questionnaire (CHAQ) and the Child Health Questionnaire (CHQ) in 32 countries. Review of the general methodology. Clin Exp Rheumatol 2001;19(4 Suppl 23):S1-9.
13. Ruperto N, Ravelli A, Falcini F, et al. Performance of the preliminary definition of improvement in juvenile chronic arthritis patients treated with methotrexate. Italian Pediatric Rheumatology Study Group. Ann Rheum Dis 1998;57:38-41.
14. Wallace CA, Ruperto N, Giannini E, et al. Trials Organization; Pediatric Rheumatology Collaborative Study Group; Preliminary criteria for clinical remission for select categories of juvenile idiopathic arthritis. J Rheumatol 2004;31:2290-2294
15. Hanauer SB, Wagner CL, Bala M, et al. Incidence and importance of antibody responses to infliximab after maintenance or episodic treatment in Crohn's disease. Clin Gastroenterol Hepatol 2004;2:542-553