Antiretroviral-related hematologic short-term toxicity in healthy infants: Implications of the new neonatal 4-week zidovudine regimen

Pediatric Infectious Disease Journal

Volumn 29, Issue 4, 2010, Pages 376-379

  Lahoz, Rebeca ^a   Noguera, Antoni ^a   Rovira, Núria ^a   Català, Albert ^c   Sánchez, Emília ^b   Jiménez, Rafael ^a   Fortuny, Clàudia ^a  

^a Departments of Pediatrics   (Spain)

^b UNIVERSITY OF BARCELONA   (Spain)

^c Catalan Agency for Health Technology Assessment and Research   (Spain)

Author keywords

Hematologic toxicity; Human immunodeficiency virus; Neonatal prophylaxis; Pediatrics; Zidovudine

Indexed keywords

ZIDOVUDINE;

ANEMIA; ARTICLE; BLOOD TOXICITY; CHEMOPROPHYLAXIS; CHILD; COHORT ANALYSIS; CONVALESCENCE; FEMALE; HEMATOLOGIC DISEASE; HEMATOLOGY; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INFANT; MAJOR CLINICAL STUDY; MALE; OBSERVATIONAL STUDY; PRIORITY JOURNAL; PROPHYLAXIS; PROSPECTIVE STUDY; VERTICAL TRANSMISSION;

EID: 77950289116     PISSN: 08913668     EISSN: 15320987     Source Type: Journal    
DOI: 10.1097/INF.0b013e3181c81fd4     Document Type: Article

References (17)

1. Centers for Disease Control and Prevention. Public Health Service Task Force. Perinatal HIV Guidelines Working Group. Recommendations for use of antiretroviral drugs in pregnant HIV-1-infected women for maternal health and interventions to reduce perinatal HIV-1 transmission in the United States. July 2008. Available at: http://AIDSinfo.nih.gov. Accessed September 1, 2009.
2. Recomendaciones de la Secretaria del Plan Nacional sobre el Sida, el Grupo de Estudio de Sida, la Sociedad Española de Ginecología y Obstetrícia y la Asociación Española de Pediatría para el seguimiento de la infección por el VIH con relación a la reproducción, el embarazo y la prevención de la transmisión vertical. Available at: www.msc.es/ciudadanos/enfLesiones/enfTransmisibles/ sida/publicaciones/publicaciones.htm. Accessed September 1, 2009.
3. Ruiter A, Mercey D, Anderson J, et al. British HIV association and children's HIV association guidelines for the management of HIV infection in pregnant women 2008. HIV Med. 2008;9:452-502.
4. Le Chenadec J, Mayaux MJ, Guihenneuc-Jouyaux C, et al. Perinatal antiretroviral treatment and hematopoiesis in HIV-uninfected infants. AIDS. 2003;17:2053-2061.
5. Bunders M, Bekker V, Scherpbier HJ, et al. Haematological parameters of HIV-1-uninfected infants born to HIV-1 infected mothers. Acta Paediatr. 2005;94:1571-1577.
6. Pacheco SE, McIntosh K, Lu M, et al. Effect of perinatal antiretroviral drug exposure on hematologic values in HIV-uninfected children: an analysis of the women and infants transmission study. J Infect Dis. 2006;194:1089-1097.
7. Feitena-Sperling C, Weizsaecker K, Bührer C, et al. Hematologic effects of maternal antiretroviral therapy and transmission prophylaxis in HIV-1-exposed uninfected newborn infants. J Acquir Immune Defic Syndr. 2007; 45:43-51.
8. Mussi-Pinhata MM, Rego MA, Freimanis L, et al. Maternal antiretrovirals and hepatic enzyme, hematologic abnormalities among human immunodeficiency virus type 1-uninfected infants. Pediatr Infect Dis J. 2007;26: 1032-1037.
9. Connor EM, Sperling RS, Gelber R, et al; Pediatric AIDS Clinical Trials Group Protocol 076 Study Group. Reduction of maternal-infant transmission of human immunodeficiency virus type 1 with zidovudine treatment. N Engl J Med. 1994;331:1173-1180
10. Centers for Disease Control and Prevention. Updated US Public Health Service guidelines for the management of occupational exposures to HIV and recommendations for postexposure prophylaxis. MMWR Recomm Rep. 2005;54(RR-9):8.
11. Division of AIDS table for grading the severity of adult and pediatric adverse events. December 2004. (niaid.nih.gov website). Available at: http://www3.niaid.nig.gov/research/resources/DAIDSClinRsrch/PDF/Safe-ty/ DAIDSAEGradingTable.pdf Accessed September 1, 2009.
12. Lallemant M, Jourdain G, Le Coeur S, et al. Single-dose perinatal nevirap-ine plus standard zidovudine to prevent mother-to-child transmission of HIV-1 in Thailand. N Engl J Med. 2004;351:217-228.
13. European Collaborative Study. Levels and patterns of neutrophil cell counts over the first 8 years of life in children of HIV-1-infected mothers. AIDS. 2004;18:2009-2017.
14. Bunders M, Thorne C, Newell ML; European Collaborative Study. Maternal and infant factors and lymphocyte, CD4 and CD8 cell counts in children of HIV-1-infected mothers. AIDS. 2005;19:1071-1079.
15. Mandelbrot L, Landreau-Mascaro A, Rekacewicz C, et al. Lamivudine-zidovudine combination for prevention of maternal-infant transmission of HIV-1. JAMA. 2001;285:2083-2093.
16. Dainiak N, Worthington M, Riordan MA, et al. 3'-Azido-3'-deoxythymidine (AZT) inhibits proliferation in vitro of human haematopoietic progenitor cells. Br J Haematol. 1988;69:299-304.
17. Shah MM, Li Y, Christensen RD. Effects of perinatal zidovudine on hemato-poiesis: a comparison of effects on progenitors from human fetuses versus mothers. AIDS. 1996;10:1239-1247.