Synthesis and study of the antifungal activity of new mono- and disubstituted derivatives of a genetically engineered polyene antibiotic 28,29-didehydronystatin A 1 (S44HP)

Journal of Antibiotics

Volumn 63, Issue 2, 2010, Pages 55-64

  Preobrazhenskaya, Maria N ^a   Olsufyeva, Eugenia N ^a   Tevyashova, Anna N ^a   Printsevskaya, Svetlana S ^a   Solovieva, Svetlana E ^a   Reznikova, Marina I ^a   Trenin, Aleksey S ^a   Galatenko, Olga A ^a   Treshalin, Ivan D ^a   Pereverzeva, Eleonora R ^a   Mirchink, Elena P ^a   Zotchev, Sergey B ^b  

^a GAUSE INSTITUTE OF NEW ANTIBIOTICS   (Russian Federation)

^b NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

Author keywords

Antifungal polyene macrolide antibiotic; Genetically engineered polyene antibiotic 28, 29 didehydro nystatin A1; Model of the candidosis sepsis; Semi synthetic macrolide antibiotics

Indexed keywords

28,29 DIDEHYDRONYSTATIN A1 DERIVATIVE; AMPHOTERICIN B; CARBOXYL GROUP; N (4 AMINOMETHYLBENZOYL) 28,29 DIDEHYDRONYSTATIN A1; POLYENE ANTIBIOTIC AGENT; UNCLASSIFIED DRUG;

ACUTE TOXICITY; AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIFUNGAL ACTIVITY; ARTICLE; CANDIDIASIS; CONTROLLED STUDY; DRUG EFFICACY; DRUG SOLUBILITY; DRUG STRUCTURE; DRUG SYNTHESIS; GENETIC ENGINEERING; LEUKOPENIA; MALE; MAXIMUM TOLERATED DOSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SEPSIS;

ANIMALS; ANTIFUNGAL AGENTS; CANDIDIASIS; GENETIC ENGINEERING; LETHAL DOSE 50; MALE; MICE; MOLECULAR STRUCTURE; NYSTATIN; SEPSIS; STRUCTURE-ACTIVITY RELATIONSHIP;

FUNGI; MUS;

EID: 77950237392     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.1038/ja.2009.118     Document Type: Article

References (9)

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