The histological development of acute antibody-mediated rejection in HLA antibody-incompatible renal transplantation

Nephrology Dialysis Transplantation

Volumn 25, Issue 4, 2010, Pages 1306-1312

  Higgins, Rob ^a   Zehnder, Daniel ^a,b   Chen, Klaus ^a   Lowe, David ^c   McKinnell, Joanna ^a   Lam, For T ^a   Kashi, Habib ^a   Tan, Lam Chin ^a   Imray, Chris ^a   Fletcher, Simon ^a   Krishnan, Nithya ^a   Hamer, Rizwan ^a,b   Briggs, David ^c  

^a UNIVERSITY HOSPITALS COVENTRY AND WARWICKSHIRE NHS TRUST   (United Kingdom)

^b UNIVERSITY OF WARWICK   (United Kingdom)

^c NHS BLOOD AND TRANSPLANT   (United Kingdom)

Author keywords

Antibody incompatible transplantation; CD20; Complement C4d; HLA antibodies; Renal allograft histology

Indexed keywords

BASILIXIMAB; CD20 ANTIGEN; CD3 ANTIGEN; CD45 ANTIGEN; CD68 ANTIGEN; COMPLEMENT COMPONENT C4D; GENZYME; HLA ANTIBODY; METHYLPREDNISOLONE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; OKT 3; PARAFFIN; PREDNISOLONE; RITUXIMAB; TACROLIMUS; THYMOCYTE ANTIBODY; UNCLASSIFIED DRUG;

ACUTE GRAFT REJECTION; ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DIAGNOSTIC VALUE; DRUG DOSE REDUCTION; DRUG MEGADOSE; FEMALE; GLOMERULUS; GRAFT DYSFUNCTION; HISTOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KIDNEY BIOPSY; KIDNEY TRANSPLANTATION; LEUKOCYTE; LYMPHOCYTIC INFILTRATION; MALE; OLIGURIA; PLASMAPHERESIS; PRIORITY JOURNAL; REPERFUSION; SCORING SYSTEM; SENSITIVITY ANALYSIS;

ADOLESCENT; ADULT; COMPLEMENT C4B; FEMALE; GRAFT REJECTION; HLA ANTIGENS; HUMANS; IMMUNOGLOBULIN G; KIDNEY DISEASES; KIDNEY TRANSPLANTATION; MALE; MIDDLE AGED; PEPTIDE FRAGMENTS; YOUNG ADULT;

EID: 77950219357     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfp610     Document Type: Article

References (21)

1. Racusen LC, Haas M. Antibody-mediated rejection in renal allografts: lessons from pathology. Clin J Am Soc Nephrol 1006; 1: 415-420
2. Halloran PF. The clinical importance of alloantibody-mediated rejection. Am J Transplant 2003; 3: 639-640
3. Racusen LC, Colvin RB, Solez K, et al. Antibody-mediated rejection criteria-an addition to the Banff 97 classification of renal allograft rejection. Am J Transplant 2003; 3: 708-714
4. Solez K, Colvin RB, Racusen LC, et al. Banff 07 classification of renal allograft pathology: updates and future directions. Am J Transplant 2008; 8: 753-760
5. McWhinnie DL, Thompson JF, Taylor HM, et al. Morphometric analysis of cellular infiltration assessed by monoclonal antibody labeling in sequential human renal allograft biopsies. Transplantation 1986; 42: 352-358
6. Kincaid-Smith P, Morris PJ, Saker BM, et al. Immediate renal graft biopsy and subsequent rejection. Lancet 1968; 2: 748-749
7. Halloran PF, Wadgymar A, Ritchie S, et al. The significance of the anti-class 1 antibody response. Transplantation 1990; 49: 85-91
8. Higgins RM, Bevan DJ, Carey BS, et al. Prevention of hyperacute rejection by removal of antibodies to HLA immediately before renal transplantation. Lancet 1996; 348: 1208-1211
9. Montgomery RA, Zachary AA, Racusen LC, et al. Plasmapheresis and intravenous immune globulin provides effective rescue therapy for refractory humoral rejection and allows kidneys to be successfully transplanted into cross-match-positive recipients. Transplantation 2000; 70: 887-895
10. Haas M, Ratner LE, Montgomery RA. C4d staining of periopera-tive renal transplant biopsies. Transplantation 2002; 74: 711-717
11. Haas M, Rahman MH, Racusen LC, et al. C4d and C3d staining in biopsies of ABO-and HLA-incompatible renal allografts: correlation with histologic findings. Am J Transplant 2006; 6: 1829-1840
12. Hass M, Montgomery RA, Segev DL, et al. Subclinical acute antibody-mediated rejection in positive crossmatch renal allografts. Am J Transplant 2007; 7: 576-585
13. Mueller TF, Einecke G, Reeve J, et al. Micoarray analysis of rejection in human kidney transplants using pathogenesis-based transcript sets. Am J Transplant 2007; 7: 2712-2722
14. Higgins R, Hathaway M, Lowe D, et al. Blood levels of donor-specific HLA antibodies after renal transplantation; resolution of rejection in the presence of circulating donor specific antibody. Transplantation 2007; 84: 876-884
15. Higgins R, Lowe D, Hathaway M, et al. Rises and falls in donor specific and third party HLA antibody levels after antibody incompatible transplantation. Transplantation 2009; 87: 882-888
16. Locke JE, Zachary AA, Haas M, et al. The utility of splenectomy as rescue treatment for severe acute antibody mediated rejection. Am J Transplant 2007; 7: 842-846
17. Gibson IW, Gwinner W, Bröcker V, et al. Peritubular capillaritis in renal allografts: prevalence, scoring system, reproducibility and clinicopathological correlates. Am J Transplant 2008; 8: 819-825
18. Feucht HE. Complement C4d in graft capillaries-the missing link in the recognition of humoral alloreactivity. Am J Transplant 2003; 646-652
19. Sis B, Famulski K, Hidalgo L, et al. Alloantibody induces C4 deposition and expression of IfNg-dependent transcripts in renal allografts in mice. Abstract, American Transplant Congress 2007
20. Magil AB. Infiltrating cell types in transplant glomerulitis: relationship to peritubular C4d deposition. Am J Kidney Dis 2005; 45: 1084-1089
21. Fahim T, Bohmig GA, Exner M, et al. The cellular lesion of humoral rejection: predominant recruitment of monocytes to peritubular and glomerular capillaries. Am J Transplant 2007; 7: 385-393