The effects of Sutherlandia frutescens extracts in cultured renal proximal and distal tubule epithelial cells

South African Journal of Science

Volumn 106, Issue 1-2, 2010, Pages 54-58

  Phulukdaree, Alisa ^a   Moodley, Devapregasan ^a   Chuturgoon, Anil A ^a  

^a UNIVERSITY OF KWAZULU NATAL   (South Africa)

Author keywords

Antioxidant; Apoptosis; Lipid peroxidation; Mitochondrial depolarisation; Sutherlandia frutescens

Indexed keywords

ANTIOXIDANT; APOPTOSIS; BIOASSAY; CANCER; CONCENTRATION (COMPOSITION); LEGUME; LIPID; MEDICINAL PLANT; MITOCHONDRION; TOXICITY; VIRAL DISEASE;

SUTHERLANDIA FRUTESCENS;

EID: 77950197746     PISSN: 00382353     EISSN: 19967489     Source Type: Journal    
DOI: 10.4102/sajs.v106i1/2.10     Document Type: Article

References (36)

1. Gericke N, Albrecht CF, Van Wyke B, Mayeng B, Mutwa C, Hutchings A. Sutherlandia frutescens. Am J Mens Health. 2001;13:9-15.
2. Tai J, Cheung S, Chan E, Hasman D. In vitro culture studies of Sutherlandia frutescens on human tumour cell lines. J Ethnopharm. 2004;9:9-19.
3. Fu X, Li X-C, Smillie TJ, et al. J Nat Prod. 2008;71:1749-1753.
4. Olivier DK, Albrecht CF, van Wyk B-E, van Heerden F. SU3, an oxocycloartane diglucoside from Sutherlandia humilis. Phytochem Lett. 2009;2:123-125.
5. Bence AK, Crooks PA. The Mechanism of L-canavanine cytotoxicity: arginyl tRNA synthetase as a novel target for anticancer drug discovery. J Enzym Inhib Med Chem. 2003;18:383-394.
6. Rosenthal GA. The biological effects and mode of action of L-canavanine, a structural analogue of L-arginine. Q Rev Biol. 1977;52:155-178.
7. Colling J, Kossman J, Makunga NP. Piecing together Sutherlandia frutescens (L.) R. Br. metabolism using in vitro tools. S Afr J Bot. 2009;75:396.
8. Crooks PA, Rosenthal GA. Use of L-canavanine as a chemotherapeutic agent for the treatment of pancreatic cancer. US Patent. 1994;5:552,440.
9. Bates SH, Jones RB, Bailey CJ. Insulin-like effect of pinitol. Br J Psychiatry. 2000;130:1944-1948.
10. Ostlund RE, Sherman WR. Pinitol and derivatives thereof for the treatment of metabolic disorders. US Patent. 1996;5:827,896.
11. Van Wyk BE. A broad review of commercially important Southern African medicinal plants. J Ethnopharm. 2008;119:342-355.
12. Sia, C. Spotlight on ehnomedicine: Usability of Sutherlandia frutescens in the treatment of diabetes. RDS. 2004;1:145-149.
13. Parducz A, Dobo E, Joachim RW, Petrusz P, Erdo SL. GABA- immunoreactive structures in rat kidneys. J Histochem Cytochem. 1992;40:675-680.
14. Shelp BJ, Bown AW, McLean MD. Metabolism and functions of gamma-aminobutyric acid. Trends Plant Sci. 1999;4:446-452.
15. Ojewole JAO. Anticonvulsant property of Sutherlandia frutescens R. BR. (variety Icnana E. MEY.) [Fabraceae] shoot aqueous extract. Brain Res Bull. 2008;75:126-132.
16. Stander BA, Marais S, Steynberg TJ, et al. Influence of Sutherlandia frutescens extracts on cell numbers, morphology and gene expression in MCF-7 cells. J Ethnopharm. 2007;112:312-318.
17. Stander A, Marias S, Stivaktas V, et al. In vitro effects of Sutherlandia frutescens water extracts on cell numbers, morphology, cell cycle progression and cell death in a tumorigenic and a non-tumorigenic epithelial breast cell line. J Ethnopharm. 2009;124:45-60.
18. Fernandes AC, Cromarty AD, Albrecht C, Van Rensburg JEC. The antioxidant potential of Sutherlandia frutescens. J Ethnopharm. 2004;95:1-5.
19. Harnett SM, Oosthuizen V, Van de Venter M. Anti-HIV activities of organic and aqueous extracts of Sutherlandia frutescens and Lobostemon trigonus. J Ethnopharm. 2005;96:113-119.
20. Klaassen CD. Cassarett and Doull's Toxicology, The basic science of poisons, 6th ed. Columbus: McGraw Hill, 2001; p. 596-600.
21. Young B, Lowe JS, Stevens A, Heath JW. Wheater's functional histology: a text and colour atlas. 4th ed. University of Michigan: Churchill Livingstone. 2000; p. 268-273.
22. Mossman T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Meth. 1983;65:55-63.
23. Berridge MV, Tan AS, Herst PM. Tetrazolium dyes as tools in Cell Biology: new insights into their cellular reduction. Biotechnol Annu Rev. 2005;11:127-152.
24. Chadwick WA, Roux S, Van de Venter M, Louw J, Oelofsen W. Anti-diabetic effects of Sutherlandia frutescens in Wistar rats fed a diabetogenic diet. J Ethnopharm. 2006;109:121-127.
25. Waterhouse NJ, Ricci J, Green DR. And all of a sudden it's over: mitochondrial outer-membrane permeabilization in apoptosis. Biochimie. 2002;84:113-121.
26. Halliwell B, Chirico S. Lipid peroxidation: its mechanism, measurement, and significance. Am J Clin Nutr. 1993;57:715-725.
27. Riganti C, Aldieri E, Bergandi L, et al. Nitroarginine methyl ester and canavanine lower intracellular reduced glutathione. Free Radic Biol Med. 2003;35:1210-1216.
28. Luzzi SD, Marletta MA. L-Arginine analogs as alternate substrates for nitric oxide synthase. Bioorg Med Chem Lett. 2005;15:3934-3941.
29. Li CQ, Wogan GN. Nitric oxide as a modulator of apoptosis. Canc Lett. 2005;226:1-15.
30. Brand MD, Chappell JB. Permeability of mitochondria from rat liver and rat brain to GABA. J Neurochem. 1973;22:47-51.
31. Lemasters JJ, Nieminen AL, Qian T. The mitochondrial permeability transition in cell death: A common mechanism in necrosis, apoptosis and autophagy. Biochim, Biophys Acta. 1998;1366:177-196.
32. Ott M, Robertson JG, Gogvadze V, Zhivotovsky B, Orrenius S. Cytochrome c release from mitochondria proceeds by a two-step process. Proc Natl Acad Sci U S A. 2002;99:1259-1263.
33. Lalier L, Cartron P-F, Juin P, et al. Bax activation and mitochondrial insertion during apoptosis. Apoptosis. 2007;12:887-896.
34. Ott M, Gogvadze V, Orrenius S, Zhitvotovsky B. Mitochondria, oxidative stress and cell death. Apoptosis. 2007;12:913-922.
35. Ojewole JAO. Analgesic, anti-inflammatory and hypoglycemic effects of Sutherlandia frutescens R.Br. (variety incana E.MEY.) [Fabaceae] shoot aqueous extract. Methods and findings in experimental and clinical pharmacology, 2004;26(6):409-416.
36. Johnson Q, Syce J, Nell H, Rudeen K, Folk WR. A randomized, double-blind, placebo-controlled trial of lessertia frutescens in healthy adults. PLOS Clinical Trials. 2007;16:0001-0007.