Dispersal kinetics of deuterated water in the lungs and airways following mouth inhalation: Real-time breath analysis by flowing afterglow mass spectrometry (FA-MS)

Journal of Breath Research

Volumn 4, Issue 1, 2010, Pages

  Tan, Boon K ^a   Smith, David ^a   Spanel, Patrik ^a,b   Davies, Simon J ^a  

^a KEELE UNIVERSITY   (United Kingdom)

^b J HEYROVSKÝ INSTITUTE OF PHYSICAL CHEMISTRY   (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

DEUTERIUM; DEUTERIUM OXIDE;

AIRWAY; ARTICLE; BREATH ANALYSIS; DISPERSION; EXPIRED AIR; FEMALE; FLOWING AFTERGLOW MASS SPECTROMETRY; HUMAN; HUMAN EXPERIMENT; INHALATION; KINETICS; LUNG EDEMA; LUNG FLUID; MALE; MASS SPECTROMETRY; NORMAL HUMAN; PILOT STUDY; PRIORITY JOURNAL; EXHALATION; LUNG CIRCULATION; LUNG EXTRAVASCULAR FLUID; METABOLISM; METHODOLOGY; PHYSIOLOGY; WATER VAPOR;

BREATH TESTS; DEUTERIUM OXIDE; EXHALATION; EXTRAVASCULAR LUNG WATER; FEMALE; HUMANS; KINETICS; MALE; MASS SPECTROMETRY; PILOT PROJECTS; PULMONARY CIRCULATION; STEAM;

EID: 77950195264     PISSN: 17527155     EISSN: 17527163     Source Type: Journal    
DOI: 10.1088/1752-7155/4/1/017109     Document Type: Article

References (17)

1. Eisenberg P R, Hansbrough J R, Anderson D and Schuster D P 1987 A prospective study of lung water measurements during patient management in an intensive care unit Am. Rev. Respir. Dis. 136 662-8
2. Sivak E D, Richmond B J, O'Donavan P B and Borkowski G P 1983 Value of extravascular lung water measurement vs portable chest x-ray in the management of pulmonary edema Crit. Care Med. 11 498-501
3. Pearce M L, Yamashita J and Beazell J 1965 Measurement of pulmonary edema Circ. Res. 16 482-8
4. Cutillo A G, Morris A H, Ailion D C, Durney C H and Case T A 1986 Determination of lung water content and distribution by nuclear magnetic resonance imaging J. Thorac. Imaging 1 39-51
5. Lange N R and Schuster D P 1999 The measurement of lung water Crit. Care 3 R19-R24
6. Meyer G J, Schober O, Bossaller C, Sturm J and Hundeshagen H 1984 Quantification of regional extravascular lung water in dogs with positron emission tomography, using constant infusion of 15O-labeled water Eur. J. Nucl. Med. 9 220-8
7. Isakow W and Schuster D P 2006 Extravascular lung water measurements and hemodynamic monitoring in the critically ill: bedside alternatives to the pulmonary artery catheter Am. J. Physiol. Lung Cell. Mol. Physiol. 291 L1118-31
8. Lilienfield L S, Freis E D, Partenope E A and Morowitz H J 1955 Transcapillary migration of heavy water and thiocyanate ion in the pulmonary circulation of normal subjects and patients with congestive heart failure J. Clin. Invest. 34 1-8
9. Wallin C J, Jacobson S H and Leksell L G 1996 Subclinical pulmonary oedema and intermittent haemodialysis Nephrol. Dial. Transplant. 11 2269-75
10. Smith D and Spanel P 2001 On-line determination of the deuterium abundance in breath water vapour by flowing afterglow mass spectrometry with applications to measurements of total body water Rapid Commun. Mass Spectrom. 15 25-32
11. Spanel P and Smith D 2001 Accuracy and precision of flowing afterglow mass spectrometry for the determination of the deuterium abundance in the headspace of aqueous liquids and exhaled breath water Rapid Commun. Mass Spectrom. 15 867-72
12. Asghar R B, Diskin A M, Spanel P, Smith D and Davies S J 2003 Measuring transport of water across the peritoneal membrane Kidney Int. 64 1911-5
13. Davies S, Spanel P and Smith D 2001 Rapid measurement of deuterium content of breath following oral ingestion to determine body water Physiol. Meas. 22 651-9
14. Meier P and Zierler K L 1954 On the theory of the indicator-dilution method for measurement of blood flow and volume J. Appl. Physiol. 6 731-44
15. Spanel P and Smith D 2005 Flowing afterglow mass spectrometry (FA-MS) for the determination of the deuterium abundance in breath water vapour and aqueous liquid headspace Breath Analysis for Clinical Diagnosis and Therapeutic Monitoring ed A Amann and D Smith (Singapore: World Scientific) pp 439-55
16. Smith D, Engel B, Diskin A M, Spanel P and Davies S J 2002 Comparative measurements of total body water in healthy volunteers by online breath deuterium measurement and other near-subject methods Am. J. Clin. Nutr. 76 1295-301
17. Anderson J C, Babb A L and Hlastala M P 2003 Modeling soluble gas exchange in the airways and alveoli Ann. Biomed. Eng. 31 1402-22