Process development of a diacyl glycerolacyltransferase-1 inhibitor

Organic Process Research and Development

Volumn 14, Issue 2, 2010, Pages 417-424

  Ravn, Matthew M ^a   Wagaw, Seble H ^a   Engstrom, Kenneth M ^a   Mei, Jianzhang ^a   Kotecki, Brian ^a   Souers, Andrew J ^a   Kym, Philip R ^a   Judd, Andrew S ^a   Zhao, Gang ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 77950171882     PISSN: 10836160     EISSN: 1520586X     Source Type: Journal    
DOI: 10.1021/op900310v     Document Type: Article

References (20)

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14. Only aqueous mixed solvent systems were expolored in the context of this work.
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17. Purchased from Johnson-Matthey.
18. Full screening results are available in the Supporting Information.
19. Carbons tested at 10 wt % loading in 2-MeTHF realtive to product: Darco G60, Ceca Acticarbone ENO-PC, 5SC-G, CPL and L3S grades.
20. Purchased from BASF Catalysts LLC, 100 Campus Drive, Florham Park, NJ 07932. Grade F4 is no longer manufactured but has been substituted with Grade F1. The performance of Grade F1 has not been verified in this system.