A synthesis of 3,5-disubstituted phenols

Organic Process Research and Development

Volumn 14, Issue 2, 2010, Pages 477-480

  Davidson, James P ^a   Sarma, Keshab ^b   Fishlock, Dan ^b   Welch, Michael H ^a   Sukhtankar, Sunil ^c   Lee, Gary M ^a   Martin, Michael ^d   Cooper, Gary F ^d  

^a ROCHE BIOSCIENCE   (United States)

^b Chemical Synthesis   (United States)

^c PFIZER INC   (United States)

^d NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 77950162687     PISSN: 10836160     EISSN: 1520586X     Source Type: Journal    
DOI: 10.1021/op900322u     Document Type: Article

References (25)

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15. Other primary alcohols would be expected to participate in the nucleophilic aromatic substitution, thus opening up the possibility of allyl-, or 2-trimethylsilylethyl-protected phenols; however, such experiments were not tested in our lab.
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23. 3-Fluoro-5-hydroxybenzonitrile was not pursued further, and no procedure was demonstrated. However, it is highly likely that the developed procedure described for 3-chloro-5-hydroxybenzonitrile would be effective.
24. Product matched the spectral properties given in ref 4.
25. Product matched the spectral properties given in ref 4.