Lhermitte's sign: Review with special emphasis in oncology practice

Critical Reviews in Oncology/Hematology

Volumn 74, Issue 2, 2010, Pages 79-86

  Gemici, Cengiz ^a  

^a DR LUTFI KIRDAR KARTAL EDUCATION AND RESEARCH HOSPITAL   (Turkey)

Author keywords

Cancer; Chemotherapy; Lhermitte's sign; Myelopathy; Neurotoxicity; Radiotherapy

Indexed keywords

BUSULFAN; CARBOPLATIN; CISPLATIN; CORTICOSTEROID; CYCLOPHOSPHAMIDE; DOCETAXEL; HEPARIN; WARFARIN;

CANCER CHEMOTHERAPY; CANCER PATIENT; CANCER RADIOTHERAPY; CERVICAL SPINAL CORD; CLINICAL FEATURE; CLINICAL PRACTICE; ELECTRIC SHOCK; HEAD AND NECK CANCER; HUMAN; HYPERBARIC OXYGEN; INCIDENCE; LHERMITTE SIGN; NECK; NERVE FIBER; NEUROLOGICAL COMPLICATION; REVIEW; SENSATION; SPINAL CORD DISEASE; SPINAL CORD TUMOR; SPINE; THORACIC SPINAL CORD; THORAX CANCER;

ANIMALS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BONE MARROW TRANSPLANTATION; HUMANS; INCIDENCE; MEDICAL ONCOLOGY; NEOPLASMS; NERVOUS SYSTEM DISEASES; NEUROSURGICAL PROCEDURES; PROFESSIONAL PRACTICE; RADIATION INJURIES; SPINAL CORD NEOPLASMS;

EID: 77950088580     PISSN: 10408428     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.critrevonc.2009.04.009     Document Type: Review

References (71)

1. Marie P., Chatelin C. Note sur certains symptomes vrais amblement d'origine radiculaire chez les blessées du crane. Rev Neurol 1917, 24:143-144.
2. Lhermitte J., Bollak A., Nicholas M. Les douleurs a type de décharge électrique consécutives a la flexion céphalique dans la sclérose en plaques. Un cas de forme sensitive de la sclerose multiple. Rev Neurol 1924, 39:56-62.
3. Gutrecht J.A. Lhermitte's sign. From observation to eponym. Arch Neurol 1989, 46:557-558.
4. Kempster P.A., Rollinson R.D. The Lhermitte phenomenon: variant forms and their significance. J Clin Neurosci 2008, 15:379-381.
5. Nordin M., Nystrom B., Wallin U., Hagbarth K.E. Ectopic sensory discharges and paresthesiae in patients with disorders of peripheral nerves, dorsal roots and dorsal columns. Pain 1984, 20:231-245.
6. Esik O., Csere T., Stefanits K., et al. A review on radiogenic Lhermitte's sign. Pathol Oncol Res 2003, 9:115-120.
7. Atkinson S.L., Li Y.Q., Wong C.S. Apoptosis and proliferation of oligodendrocyte progenitor cells in the irradiated rodent spinal cord. Int J Radiat Oncol Biol Phys 2005, 62:535-544.
8. Butler W.M., Taylor H.G., Diehl L.F. Lhermitte's sign in cobalamin (vitamin B12) deficiency. JAMA 1981, 245:1059.
9. Martin D. Lhermitte's sign and cobalamin deficiency. JAMA 1982, 247:28.
10. Sandyk R., Brennan J.W. "Lhermitte's sign" as a presenting symptom of subacute combined degeneration of the cord. Ann Neurol 1983, 13:215-216.
11. Gautier-Smith P.C. Lhermitte's sign in subacute combined degeneration of the cord. J Neurol Neurosurg Psychiatry 1973, 36:861-863.
12. Gutrecht J.A., Zamani A.A., Salgado E.D. Anatomic-radiologic basis of Lhermitte's sign in multiple sclerosis. Arch Neurol 1993, 50:849-851.
13. Fritschi J., Sturzenegger M. Spinal MRI supporting myelopathic origin of early symptoms in unsuspected cobalamin deficiency. Eur Neurol 2003, 49:146-150.
14. Miller D.H., McDonald W.I., Blumhardt L.D., et al. Magnetic resonance imaging in isolated noncompressive spinal cord syndromes. Ann Neurol 1987, 22:714-723.
15. Imai T., Tsuda E., Suzuki M., Hozuki T., Matsumoto H. Lhermitte's sign in alcoholic myelopathy without portosytemic shunting: MRI evaluation. Intern Med 2005, 44:153-154.
16. Bassi S.S., Bulundwe K.K., Greeff G.P., Labuscagne J.H., Gledhill R.F. MRI of the spinal cord in myelopathy complicating vitamin B12 deficiency: two additional cases and a review of the literature. Neuroradiology 1999, 41:271-274.
17. Hodges S.D., Castleberg R.L., Miller T., Ward R., Thornburg C. Cervical epidural steroid injection with intrinsic spinal cord damage. Two case reports. Spine 1998, 23:2137-2142.
18. Traynelis V.C., Hitchon P.W., Yuh W.T., Kaufman H.H. Magnetic resonance imaging and posttraumatic Lhermitte's sign. J Spinal Disord 1990, 3:376-379.
19. Newton H.B., Rea G.L. Lhermitte's sign as a presenting symptom of primary spinal cord tumor. J Neurooncol 1996, 29:183-188.
20. Klimo P., Blumenthal D.T., Couldwell W.T. Congenital partial aplasia of the posterior arch of the atlas causing myelopathy: case report and review of the literature. Spine 2003, 28:E224-E228.
21. Ventafridda V., Caraceni A., Martini C., Sbanotto A., De Conno F. On the significance of Lhermitte's sign in oncology. J Neurooncol 1991, 10:133-137.
22. Esik O., Csere T., Stefanits K., et al. Increased metabolic activity in the spinal cord of patients with long-standing Lhermitte's sign. Strahlenther Onkol 2003, 179:690-693.
23. Kanchandani R., Howe J.G. Lhermitte's sign in multiple sclerosis: a clinical survey and review of the literature. J Neurol Neurosurg Psy 1982, 45:308-312.
24. Al-Araji A.H., Oger J. Reappraisal of Lhermitte's sign in multiple sclerosis. Mult Scler 2005, 11:389-402.
25. Solaro C., Brichetto G., Amato M.P., et al. The prevalence of pain in multiple sclerosis: a multicenter cross-sectional study. Neurology 2004, 63:919-921.
26. Arasil E., Tascioglu A.O. Spontaneous migration of an intracranial bullet to the cervical spinal canal causing Lhermitte's sign. Case report. J Neurosurg 1982, 56:158-159.
27. Chan R.C., Steinbok P. Delayed onset Lhermitte's sign following head and/or neck injuries. Report of four cases. J Neurosurg 1984, 60:609-612.
28. Leaver R.C., Loeser J.D. Lhermitte's phenomenon after high velocity missile injuries of the brain. J Neurosurg 1971, 34:159-163.
29. Merriam W.F., Taylor T.K., Ruff S.J., McPhail M.J. A reappraisal of acute traumatic central cord syndrome. J Bone Joint Surg Br 1986, 68:708-713.
30. Vollmer T.L., Brass L.M., Waxman S.G. Lhermitte's sign in a patient with herpes zoster. J Neurol Sci 1991, 106:153-157.
31. Falga-Tirado C., Ordi-Ros J., Perez-Peman P., Cucurull-Canosa E., Bosch-Gil J. Lhermitte's sign in Behcet's disease. Br J Rheumatol 1995, 34:184-185.
32. Page N.G., Spiteri M.A. Lhermitte's sign in Behcet's disease. Br Med J (Clin Res Ed) 1982, 284:704-705.
33. Falga-Tirado C., Ordi-Ros J., Cucurull-Canosa E., Soler-Ferrer C. Lhermitte's sign in systemic lupus erythematosus. Lupus 1995, 4:327.
34. Lunsford J.M., Wynn M.H., Kwan W.H. Nitrous oxide-induced myeloneuropathy. J Foot Surg 1983, 22:222-225.
35. Layzer R.B. Myeloneuropathy after prolonged exposure to nitrous oxide. Lancet 1978, 2:1227-1230.
36. Blanco G., Peters H.A. Myeloneuropathy and macrocytosis associated with nitrous oxide abuse. Arch Neurol 1983, 40:416-418.
37. Murphy D.K., Gutrecht J.A. Lhermitte's sign in cavernous angioma of the cervical spinal cord. J Neurol Neurosurg Psychiatry 1998, 65:954-955.
38. Palace J. Making the diagnosis of multiple sclerosis. J Neurol Neurosurg Psychiatry 2001, 71(Suppl. 2):ii3-ii8.
39. St Clair W.H., Arnold S.M., Sloan A.E., Regine W.F. Spinal cord and peripheral nerve injury: current management and investigations. Sem Radiat Oncol 2003, 13:322-332.
40. Delattre J.Y., Rosenblum M.K., Thaler H.T., Mandell L., Shapiro W.R., Posner J.B. A model of radiation myelopathy in the rat. Pathology, regional capillary permeability changes and treatment with dexamethasone. Brain 1988, 111:1319-1336.
41. Leung W.M., Tsang N.M., Chang F.T., Lo F.T. Lhermitte's sign among nasopharyngeal cancer patients after radiotherapy. Head Neck 2005, 27:187-194.
42. Fein D.A., Marcus R.B., Parsons J.T., Mendenhall W.M., Million R.R. Lhermitte's sign: incidence and treatment variables influencing risk after irradiation of the cervical spinal cord. Int J Radiat Oncol Biol Phys 1993, 27:1029-1033.
43. Marcus R.B., Million R.R. The incidence of myelitis after irradiation of the cervical spinal cord. Int J Radiat Oncol Biol Phys 1990, 19:3-8.
44. Keime-Guibert F., Napolitano M., Delattre J.Y. Neurological complications of radiotherapy and chemotherapy. J Neurol 1998, 245:695-708.
45. Tuxen M.K., Hansen S.W. Neurotoxicity secondary to antineoplastic agents. Cancer Treat Rev 1994, 20:191-214.
46. Dropcho E.J. Neurotoxicity of cancer chemotherapy. Semin Neurol 2004, 24:419-426.
47. Hausheer F.H., Schilsky R.L., Bain S., Berghorn E.J., Lieberman F. Diagnosis, management, and evaluation of chemotherapy-induced peripheral neuropathy. Semin Oncol 2006, 33:15-49.
48. Sul J.K., DeAngelis L.M. Neurologic complications of cancer chemotherapy. Semin Oncol 2006, 33:324-332.
49. Eeles R., Tait D.M., Peckham M.J. Lhermitte's sign as a complication of cisplatin-containing chemotherapy for testicular cancer. Cancer Treat Rep 1986, 70:905-907.
50. Inbar M., Merimsky O., Wigler N., Chaitchik S. Cisplatin-related Lhermitte's sign. Anticancer Drugs 1992, 3:375-377.
51. Dewar J., Lunt H., Abernethy D.A., Dady P., Haas L.F. Cisplatin neuropathy with Lhermitte's sign. J Neurol Neurosurg Psychiatry 1986, 49:96-99.
52. Walther P.J., Rossitch E., Bullard D.E. The development of Lhermitte's sign during cisplatin chemotherapy. Possible drug-induced toxicity causing spinal cord demyelination. Cancer 1987, 60:2170-2172.
53. Siegal T., Haim N. Cisplatin-induced peripheral neuropathy. Frequent off-therapy deterioration, demyelinating syndromes, and muscle cramps. Cancer 1990, 66:1117-1123.
54. List A.F., Kummet T.D. Spinal cord toxicity complicating treatment with cisplatin and etoposide. Am J Clin Oncol 1990, 13:256-258.
55. Hilkens P.H., Verweij J., Stoter G., Vecht C.J., van Putten W.L., van den Bent M.J. Peripheral neurotoxicity induced by docetaxel. Neurology 1996, 46:104-108.
56. Van den Bent M.J., Hilkens P.H., Sillevis Smitt P.A., van Raaij-van den Aarssen V.J., Bontenbal M., Verweij J. Lhermitte's sign following chemotherapy with docetaxel. Neurology 1998, 50:563-564.
57. Taieb S., Trillet-Lenoir V., Rambaud L., Descos L., Freyer G. Lhermitte sign and urinary retention: atypical presentation of oxaliplatin neurotoxicity in four patients. Cancer 2002, 94:2434-2440.
58. Ciucci G., De Giorgi U., Leoni M., Bianchedi G. Lhermitte's sign following oxaliplatin-containing chemotherapy in a cisplatin-pretreated ovarian cancer patient. Eur J Neurol 2003, 10:328-329.
59. Walsh T.J., Clark A.W., Parhad I.M., Green W.R. Neurotoxic effects of cisplatin therapy. Arch Neurol 1982, 39:719-720.
60. Brienza S., Vignoud J., Itzhaki M. Oxaliplatin: global safety in 682 patients. Proc Am Soc Clin Oncol 1995, 14:209.
61. Jurado J.M., Pajares B., Olmos D., Sevilla I., Alba E. 'Out of blue' Lhermitte's sign: three cases due to low cumulative doses of oxaliplatin. Ann Oncol 2008, 19:2093-2094.
62. Heinzlef O., Lotz J.P., Roullet E. Severe neuropathy after high dose carboplatin in three patients receiving multidrug chemotherapy. J Neurol Neurosurg Psychiatry 1998, 64:667-669.
63. Wen P.Y., Blanchard K.L., Block C.C., et al. Development of Lhermitte's sign after bone marrow transplantation. Cancer 1992, 69:2262-2266.
64. Denis F., Garaud P., Bardet E., et al. Late toxicity results of the GORTEC 94-01 randomized trial comparing radiotherapy with concomitant radiochemotherapy for advanced-stage oropharynx carcinoma: comparison of LENT/SOMA, RTOG/EORTC, and NCI-CTC scoring systems. Int J Radiat Oncol Biol Phys 2003, 55:93-98.
65. de Brabander C., Cornelissen J., Smitt P.A., Vecht C.J., van den Bent M.J. Increased incidence of neurological complications in patients receiving an allogenic bone marrow transplantation from alternative donors. J Neurol Neurosurg Psychiatry 2000, 68:36-40.
66. Rosenfeld M.R., Pruitt A. Neurologic complications of bone marrow, stem cell, and organ transplantation in patients with cancer. Semin Oncol 2006, 33:352-361.
67. Baldwin R.N., Chadwick D. Lhermitte's sign due to thoracic cord compression. J Neurol Neurosurg Psychiatry 1986, 49:840-841.
68. Rogers L.R. Thoracic cord compression from metastatic prostate carcinoma with Lhermitte's sign. J Neurol Neurosurg Psychiatry 1987, 50:1086.
69. Lewanski C.R., Sinclair J., Stewart J.S.W. Lhermitte's sign following head and neck radiotherapy. Clin Oncol (R Coll Radiol) 2000, 12:98-103.
70. Glantz M.J., Burger P.C., Friedman A.H., Radtke R.A., Massey E.W., Schold S.C. Treatment of radiation induced nervous system injury with heparin and warfarin. Neurology 1994, 44:2020-2027.
71. Calabro F., Jinkins J.R. MRI of radiation myelitis: a report of a case treated with hyperbaric oxygen. Eur Radiol 2000, 10:1079-1084.