Triazines incorporating (R)-3-methylmorpholine are potent inhibitors of the mammalian target of rapamycin (mTOR) with selectivity over PI3Kα

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 8, 2010, Pages 2654-2657

  Richard, David J ^a   Verheijen, Jeroen C ^a   Yu, Ker ^a   Zask, Arie ^a  

^a WYETH RESEARCH   (United States)

Author keywords

Cancer; Kinase inhibitors; mTOR; Oncology; PI3K

Indexed keywords

MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; MORPHOLINE DERIVATIVE; PHOSPHATIDYLINOSITOL 3 KINASE; TRIAZINE DERIVATIVE;

ARTICLE; DRUG ACTIVITY; DRUG SELECTIVITY; DRUG SYNTHESIS; HUMAN;

1-PHOSPHATIDYLINOSITOL 3-KINASE; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MORPHOLINES; PROTEIN-SERINE-THREONINE KINASES; TRIAZINES;

MAMMALIA;

EID: 77950050825     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.02.029     Document Type: Article

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