Focus on Molecules: ELOVL4

Experimental Eye Research

Volumn 90, Issue 4, 2010, Pages 476-477

  Bedell, Matthew ^a   Harkewicz, Richard ^b   Wang, Xiaolei ^a   Zhang, Kang ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b San Diego   (United States)

Author keywords

ELOVL4; Stargardt like macular dystrophy; STGD3; Very long chain polyunsaturated fatty acids; VLC PUFAs

Indexed keywords

ELONGATION OF VERY LONG CHAIN FATTY ACID 4; MUTANT PROTEIN; UNCLASSIFIED DRUG; VERY LONG CHAIN FATTY ACID;

CAUSAL ATTRIBUTION; CELLULAR DISTRIBUTION; FATTY ACID ANALYSIS; GENE FUNCTION; GENE MUTATION; HUMAN; MOLECULAR DYNAMICS; NONHUMAN; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RETINA DEGENERATION; RETINA DEVELOPMENT; SHORT SURVEY; STARGARDT DISEASE; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ANIMALS; EYE PROTEINS; HUMANS; MEMBRANE PROTEINS; MICE; RETINAL DEGENERATION;

EID: 77950020713     PISSN: 00144835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exer.2009.10.010     Document Type: Short Survey

References (4)

1. Agbaga M., Brush R.S., Mandal M.N., Henry K., Elliott M.H., Anderson R.E. Role of stargardt-3 macular dystrophy protein (ELOVL4) in the biosynthesis of very long chain fatty acids. Proc. Natl. Acad. Sci. USA 2008, 105:12843-12848.
2. Cameron D.J., Tong Z., Yang Z., Kaminoh J., Kamiyah S., Chen H., Zeng J., Chen Y., Luo L., Zhang K. Essential role of Elovl4 in very long chain fatty acid synthesis, skin permeability barrier function, and neonatal survival. Int. J. Biol. Sci. 2007, 3:111-119.
3. Karan G., Lillo C., Yang Z., Cameron D.J., Locke K.G., Zhao Y., Thirumalaichary S., Li C., Birch D.G., Vollmer-Snarr H.R., Williams D.S., Zhang K. Lipofuscin accumulation, abnormal electrophysiology, and photoreceptor degeneration in mutant ELOVL4 transgenic mice: a model for macular degeneration. Proc. Natl. Acad. Sci. USA 2005, 102:4164-4169.
4. Zhang K., Kniazeva M., Han M., Li W., Yu Z., Yang Z., Li Y., Metzker M.L., Allikmets R., Zack D.J., Kakuk L.E., Lagali P.S., Wong P.W., MacDonald I.M., Sieving P.A., Figueroa D.J., Austin C.P., Gould R.J., Ayyagari R., Petrukhin K. A 5-bp deletion in ELOVL4 is associated with two related forms of autosomal dominant macular dystrophy. Nat. Genet. 2001, 27:89-93.