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Volumn 70, Issue 5, 2010, Pages 631-642

Raltegravir: In treatment-naive patients with hiv-1 infection

Author keywords

[No Author keywords available]

Indexed keywords

EFAVIRENZ; EMTRICITABINE PLUS TENOFOVIR DISOPROXIL; LAMIVUDINE; OMEPRAZOLE; PLACEBO; PROTEINASE INHIBITOR; RALTEGRAVIR; RIFAMPICIN; RNA DIRECTED DNA POLYMERASE INHIBITOR; TENOFOVIR; VIRUS RNA;

EID: 77949919965     PISSN: 00126667     EISSN: 11791950     Source Type: Journal    
DOI: 10.2165/11204590-000000000-00000     Document Type: Review
Times cited : (25)

References (42)
  • 1
    • 77949935075 scopus 로고    scopus 로고
    • Joint United Nations Programme on HIV/AIDS. 2009 AIDS epidemic update [online] [Accessed 2009 Dec 21]
    • Joint United Nations Programme on HIV/AIDS. 2009 AIDS epidemic update [online]. Available from URL http://data. unaids.org/pub/Report/2009/2009- epidemic-update-en.pdf [Accessed 2009 Dec 21].
  • 2
    • 77949950716 scopus 로고    scopus 로고
    • WHO UNAIDS UNICEF. Towards universal access: scaling up priority HIV/AIDS interventions in the health sector: progress report 2008 [online] [Accessed 2008 Nov 26]
    • WHO, UNAIDS, UNICEF. Towards universal access: scaling up priority HIV/AIDS interventions in the health sector: progress report 2008 [online]. Available from URL: http://www.who.int/hiv/pub/towards-universal-access-report- 2008.pdf [Accessed 2008 Nov 26]
  • 3
    • 77949991209 scopus 로고    scopus 로고
    • WHO. Global HIV prevalence has levelled off: improvements in surveillance increase understanding of the epidemic, resulting in substantial revisions to estimates [online] [Accessed 2008 Nov 26]
    • WHO. Global HIV prevalence has levelled off: improvements in surveillance increase understanding of the epidemic, resulting in substantial revisions to estimates [online]. Available from URL http://www.who.int/mediacentre/news/ releases/2007/pr61/en/print.html [Accessed 2008 Nov 26]
  • 4
    • 47949131197 scopus 로고    scopus 로고
    • HIV integrase inhibitors: Out of the pipeline and into the clinic
    • Jul 24
    • Havlir DV. HIV integrase inhibitors: out of the pipeline and into the clinic. N Engl J Med 2008 Jul 24; 359 (4): 416-418
    • (2008) N Engl J Med , vol.359 , Issue.4 , pp. 416-418
    • Havlir, D.V.1
  • 5
    • 0037124139 scopus 로고    scopus 로고
    • Guidelines for using antiretroviral agents among HIV-infected adults and adolescents: Recommendations of the Panel on Clinical Practices for Treatment of HIV
    • May 17
    • Dybul M, Fauci AS, Bartlett JG, et al. Guidelines for using antiretroviral agents among HIV-infected adults and adolescents: recommendations of the Panel on Clinical Practices for Treatment of HIV. MMWR Recomm Rep 2002 May 17; 51 (RR-7): 1-55
    • (2002) MMWR Recomm Rep , vol.51 , Issue.RR-7 , pp. 1-55
    • Dybul, M.1    Fauci, A.S.2    Bartlett, J.G.3
  • 6
    • 33646812239 scopus 로고    scopus 로고
    • Tracking the prevalence of transmitted antiretroviral drug-resistant HIV-1
    • Shet A, Berry L, Mohri H, et al. Tracking the prevalence of transmitted antiretroviral drug-resistant HIV-1. J Acquir Immune Defic Syndr 2006; 41 (4): 439-446
    • (2006) J Acquir Immune Defic Syndr , vol.41 , Issue.4 , pp. 439-446
    • Shet, A.1    Berry, L.2    Mohri, H.3
  • 7
    • 3142660152 scopus 로고    scopus 로고
    • The prevalence of antiretroviral drug resistance in the United States
    • Richman D, Morton S, Wrin T, et al. The prevalence of antiretroviral drug resistance in the United States. AIDS 2004; 18 (10): 1393-1401
    • (2004) AIDS , vol.18 , Issue.10 , pp. 1393-1401
    • Richman, D.1    Morton, S.2    Wrin, T.3
  • 8
    • 65249180642 scopus 로고    scopus 로고
    • Emerging pharmacology: Inhibitors of human immunodeficiency virus integration
    • Hazuda D, Iwamoto M, Wenning L. Emerging pharmacology: inhibitors of human immunodeficiency virus integration. Annu Rev Pharmacol Toxicol 2009; 49: 377-394
    • (2009) Annu Rev Pharmacol Toxicol , vol.49 , pp. 377-394
    • Hazuda, D.1    Iwamoto, M.2    Wenning, L.3
  • 9
    • 77949965315 scopus 로고    scopus 로고
    • DHSS Panel on Antiretroviral Guidelines for Adults and Adolescents: a working group of the Office of AIDS Research Advisory Council (OARAC). Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents [online] [Accessed 2010 Jan 20]
    • DHSS Panel on Antiretroviral Guidelines for Adults and Adolescents: a working group of the Office of AIDS Research Advisory Council (OARAC). Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents [online]. Available from URL http://aidsinfo.nih.gov/contentfiles/ AdultandAdolescentGL.pdf [Accessed 2010 Jan 20]
  • 10
    • 48949097660 scopus 로고    scopus 로고
    • Antiretroviral treatment of adult HIV infection 2008 recommendations of the International AIDS Society-USA panel
    • Hammer SM, Eron Jr JJ, Reiss P. Antiretroviral treatment of adult HIV infection: 2008 recommendations of the International AIDS Society-USA panel. JAMA 2008; 300 (5): 555-570
    • (2008) JAMA , vol.300 , Issue.5 , pp. 555-570
    • Hammer, S.M.1    Eron Jr., J.J.2    Reiss, P.3
  • 11
    • 52749083531 scopus 로고    scopus 로고
    • British HIV Association guidelines for the treatment of HIV-1-infected adults with antiretroviral therapy 2008
    • Gazzard BG. British HIV Association guidelines for the treatment of HIV-1-infected adults with antiretroviral therapy 2008. HIV Med 2008; 9 (8): 563-608
    • (2008) HIV Med , vol.9 , Issue.8 , pp. 563-608
    • Gazzard, B.G.1
  • 12
    • 77950015721 scopus 로고    scopus 로고
    • European AIDS Clinical Society (EACS). Guidelines for the clinical management and treatment of HIV infected adults in Europe [online] [Accessed 2010 Jan 20]
    • European AIDS Clinical Society (EACS). Guidelines for the clinical management and treatment of HIV infected adults in Europe [online]. Available from URL http://europeanaidsclinicalsociety.org/guidelinespdf/1-Treatment-of- HIV-Infected-Adults.pdf [Accessed 2010 Jan 20]
  • 13
    • 70149095523 scopus 로고    scopus 로고
    • Primary care guidelines for the management of persons infected with human immunodeficiency virus 2009 update by the HIV Medicine Association of the Infectious Diseases Society of America
    • Adberg JA, Kaplan JE, Libman H, et al. Primary care guidelines for the management of persons infected with human immunodeficiency virus: 2009 update by the HIV Medicine Association of the Infectious Diseases Society of America. Clin Infect Dis 2009; 49 (5): 651-681
    • (2009) Clin Infect Dis , vol.49 , Issue.5 , pp. 651-681
    • Adberg, J.A.1    Kaplan, J.E.2    Libman, H.3
  • 16
    • 66949136295 scopus 로고    scopus 로고
    • Raltegravir: A review of its use in the management of HIV infection in treatment-experienced patients
    • Croxtall JD, Keam SJ. Raltegravir: a review of its use in the management of HIV infection in treatment-experienced patients. Drugs 2009; 69 (8): 1059-1075
    • (2009) Drugs , vol.69 , Issue.8 , pp. 1059-1075
    • Croxtall, J.D.1    Keam, S.J.2
  • 17
    • 33947715164 scopus 로고    scopus 로고
    • Role of integrase inhibitors in the treatment of HIV disease: Expert review of anti-infective therapy
    • Palmisano L. Role of integrase inhibitors in the treatment of HIV disease: expert review of anti-infective therapy. Expert Rev Anti Infect Ther 2007; 5 (1): 67-75
    • (2007) Expert Rev Anti Infect Ther , vol.5 , Issue.1 , pp. 67-75
    • Palmisano, L.1
  • 18
    • 52449097240 scopus 로고    scopus 로고
    • Discovery of raltegravir, a potent, selective orally bioavailable HIV-integrase inhibitor for the treatment of HIV-AIDS infection
    • Summa V, Petrocchi A, Bonelli F, et al. Discovery of raltegravir, a potent, selective orally bioavailable HIV-integrase inhibitor for the treatment of HIV-AIDS infection. J Med Chem 2008; 51 (18): 5843-5855
    • (2008) J Med Chem , vol.51 , Issue.18 , pp. 5843-5855
    • Summa, V.1    Petrocchi, A.2    Bonelli, F.3
  • 19
    • 54049102468 scopus 로고    scopus 로고
    • Drug resistance profiles for the HIV integrase gene in patients failing raltegravir salvage therapy
    • Charpentier C, Karmochkine M, Laureillard D, et al. Drug resistance profiles for the HIV integrase gene in patients failing raltegravir salvage therapy. HIV Med 2008; 9 (9): 765-770
    • (2008) HIV Med , vol.9 , Issue.9 , pp. 765-770
    • Charpentier, C.1    Karmochkine, M.2    Laureillard, D.3
  • 20
    • 67149113903 scopus 로고    scopus 로고
    • Constraints on the dominant mechanism for HIV viral dynamics in patients on raltegravir
    • Sedaghat AR, Siliciano RF, Wilke CO. Constraints on the dominant mechanism for HIV viral dynamics in patients on raltegravir. Antivir Ther 2009; 14 (2): 263-271
    • (2009) Antivir Ther , vol.14 , Issue.2 , pp. 263-271
    • Sedaghat, A.R.1    Siliciano, R.F.2    Wilke, C.O.3
  • 21
    • 62349120391 scopus 로고    scopus 로고
    • Dynamic patterns of human immunodeficiency virus type 1 integrase gene evolution in patients failing raltegravir-based salvage therapies
    • Feb 20
    • Canducci F, Sampaolo M, Marinozzi MC, et al. Dynamic patterns of human immunodeficiency virus type 1 integrase gene evolution in patients failing raltegravir-based salvage therapies. AIDS 2009 Feb 20; 23 (No.4): 455-460
    • (2009) AIDS , vol.23 , Issue.4 , pp. 455-460
    • Canducci, F.1    Sampaolo, M.2    Marinozzi, M.C.3
  • 22
    • 62549166235 scopus 로고    scopus 로고
    • Quasispecies variant dynamics during emergence of resistance to raltegravir in HIV-1-infected patients
    • Apr 1
    • Malet I, Delelis O, Soulie C, et al. Quasispecies variant dynamics during emergence of resistance to raltegravir in HIV-1-infected patients. J Antimicrob Chemother 2009 Apr 1; 63 (4): 795-804
    • (2009) J Antimicrob Chemother , vol.63 , Issue.4 , pp. 795-804
    • Malet, I.1    Delelis, O.2    Soulie, C.3
  • 23
    • 70350666377 scopus 로고    scopus 로고
    • Loss of raltegravir susceptibility of HIV-1 is conferred by multiple non-overlapping genetic pathways
    • Fransen S, Gupta S, Danovich R, et al. Loss of raltegravir susceptibility of HIV-1 is conferred by multiple non-overlapping genetic pathways. J Virol 2009; 83 (22): 11440-11446
    • (2009) J Virol , vol.83 , Issue.22 , pp. 11440-11446
    • Fransen, S.1    Gupta, S.2    Danovich, R.3
  • 24
    • 70349337790 scopus 로고    scopus 로고
    • Longitudinal analysis of raltegravir susceptibility and integrase replication capacity of human immunodeficiency virus type 1 during virologic failure
    • Oct
    • Fransen S, Karmochkine M, Huang W, et al. Longitudinal analysis of raltegravir susceptibility and integrase replication capacity of human immunodeficiency virus type 1 during virologic failure. Antimicrob Agents Chemother 2009 Oct; 53 (10): 4522-4524
    • (2009) Antimicrob Agents Chemother , vol.53 , Issue.10 , pp. 4522-4524
    • Fransen, S.1    Karmochkine, M.2    Huang, W.3
  • 25
    • 70350156722 scopus 로고    scopus 로고
    • The dynamics of appearance and disappearance of HIV-1 integrase mutations during and after withdrawal of raltegravir therapy
    • Ferns RB, Kirk S, Bennett J, et al. The dynamics of appearance and disappearance of HIV-1 integrase mutations during and after withdrawal of raltegravir therapy. AIDS 2009; 23 (16): 2159-2164
    • (2009) AIDS , vol.23 , Issue.16 , pp. 2159-2164
    • Ferns, R.B.1    Kirk, S.2    Bennett, J.3
  • 26
    • 73649137500 scopus 로고    scopus 로고
    • The HIV-1 integrase genotype strongly predicts raltegravir susceptibility but not viral fitness of primary virus isolates
    • Buzon MJ, Dalmau J, Puertas MC, et al. The HIV-1 integrase genotype strongly predicts raltegravir susceptibility but not viral fitness of primary virus isolates. AIDS 2009; 24 (1): 17-25
    • (2009) AIDS , vol.24 , Issue.1 , pp. 17-25
    • Buzon, M.J.1    Dalmau, J.2    Puertas, M.C.3
  • 27
    • 67249085974 scopus 로고    scopus 로고
    • Evolution of raltegravir resistance during therapy
    • Jul
    • Sichtig N, Sierra S, Kaiser R, et al. Evolution of raltegravir resistance during therapy. J Antimicrob Chemother 2009 Jul; 64 (1): 25-32
    • (2009) J Antimicrob Chemother , vol.64 , Issue.1 , pp. 25-32
    • Sichtig, N.1    Sierra, S.2    Kaiser, R.3
  • 28
    • 34748860363 scopus 로고    scopus 로고
    • Rapid and durable antiretroviral effect of the HIV-1 integrase inhibitor raltegravir as part combination therapy in treatment-naive patients with HIV-1 infection
    • Markowitz M, Nguyen B-Y, Gotuzzo E, et al. Rapid and durable antiretroviral effect of the HIV-1 integrase inhibitor raltegravir as part combination therapy in treatment-naive patients with HIV-1 infection. J Acquir Immune Defic Syndr 2007; 46 (2): 125-133
    • (2007) J Acquir Immune Defic Syndr , vol.46 , Issue.2 , pp. 125-133
    • Markowitz, M.1    Nguyen, B.-Y.2    Gotuzzo, E.3
  • 29
    • 70350558421 scopus 로고    scopus 로고
    • Sustained antiretroviral effect of raltegravir after 96 weeks of combination therapy in treatment-naive patients with HIV-1 infection
    • Nov
    • Markowitz M, Nguyen BY, Gotuzzo E, et al. Sustained antiretroviral effect of raltegravir after 96 weeks of combination therapy in treatment-naive patients with HIV-1 infection. J Acquir Immune Defic Syndr 2009 Nov; 52 (3): 350-356
    • (2009) J Acquir Immune Defic Syndr , vol.52 , Issue.3 , pp. 350-356
    • Markowitz, M.1    Nguyen, B.Y.2    Gotuzzo, E.3
  • 30
    • 69449101785 scopus 로고    scopus 로고
    • Safety and efficacy of raltegravir-based versus efavirenz-based combination therapy in treatment-naive patients with HIV-1 infection: A multicentre, double-blind randomised controlled trial
    • Sep 5
    • Lennox JL, DeJesus E, Lazzarin A, et al. Safety and efficacy of raltegravir-based versus efavirenz-based combination therapy in treatment-naive patients with HIV-1 infection: a multicentre, double-blind randomised controlled trial. Lancet 2009 Sep 5; 374 (9692): 796-806
    • (2009) Lancet , vol.374 , Issue.9692 , pp. 796-806
    • Lennox, J.L.1    Dejesus, E.2    Lazzarin, A.3
  • 31
    • 77953913027 scopus 로고    scopus 로고
    • Raltegravir demonstrates durable efficacy through 96 weeks: Results from STARTMRK a phase III study of raltegravir-based vs. efavirenz-based therapy in treatment-naive HIV+ patients [abstract no. H-924b]
    • Sep 12; San Francisco (CA)
    • Lennox J, De Jesus E, Lazzarin A, et al. Raltegravir demonstrates durable efficacy through 96 weeks: results from STARTMRK, a phase III study of raltegravir-based vs. efavirenz-based therapy in treatment-naive HIV+ patients [abstract no. H-924b]. 49th Interscience Conference on Antimicrobial Agents and Chemotherapy; 2009 Sep 12; San Francisco (CA)
    • (2009) 49th Interscience Conference on Antimicrobial Agents and Chemotherapy
    • Lennox, J.1    De Jesus, E.2    Lazzarin, A.3
  • 32
    • 77949958735 scopus 로고    scopus 로고
    • Merck and Co. Inc. Isentress (raltegravir) US prescribing information. Whitehouse Station (NJ): Merck and Co. Inc., 2009
    • Merck and Co. Inc. Isentress (raltegravir): US prescribing information. Whitehouse Station (NJ): Merck and Co. Inc., 2009
  • 33
    • 77949962065 scopus 로고    scopus 로고
    • European Medicines Agency. Raltegravir: summary of product characteristics [online] [Accessed 2009 Dec 4]
    • European Medicines Agency. Raltegravir: summary of product characteristics [online]. Available from URL: http://www.emea.europa.eu/ humandocs/PDFs/EPAR/isentress/emea-combined-h860en.pdf [Accessed 2009 Dec 4]
  • 34
    • 44049105253 scopus 로고    scopus 로고
    • Raltegravir thorough QT/QTc study: A single supratherapeutic dose of raltegravir does not prolong the QTcF interval
    • Iwamoto M, Kost JT, Mistry GC, et al. Raltegravir thorough QT/QTc study: a single supratherapeutic dose of raltegravir does not prolong the QTcF interval. J Clin Pharmacol 2008; 48 (6): 726-733
    • (2008) J Clin Pharmacol , vol.48 , Issue.6 , pp. 726-733
    • Iwamoto, M.1    Kost, J.T.2    Mistry, G.C.3
  • 35
    • 34548065793 scopus 로고    scopus 로고
    • Metabolism and disposition in humans of raltegravir (MK-0518), an anti-AIDS drug targeting the HIV-1 integrase enzyme
    • Kassahun K, McIntosh I, Cui D, et al. Metabolism and disposition in humans of raltegravir (MK-0518), an anti-AIDS drug targeting the HIV-1 integrase enzyme. Drug Metab Dispos 2007; 35 (9): 1657-1663
    • (2007) Drug Metab Dispos , vol.35 , Issue.9 , pp. 1657-1663
    • Kassahun, K.1    McIntosh, I.2    Cui, D.3
  • 36
    • 33845366857 scopus 로고    scopus 로고
    • Antiretroviral activity, pharmacokinetics, and tolerability of MK-0518, a novel inhibitor of HIV-1 integrase, dosed as monotherapy for 10 days in treatment-naive HIV-1-infected individuals
    • Markowitz M, Morales-Ramirez JO, Nguyen BY, et al. Antiretroviral activity, pharmacokinetics, and tolerability of MK-0518, a novel inhibitor of HIV-1 integrase, dosed as monotherapy for 10 days in treatment-naive HIV-1-infected individuals. J Acquir Immune Defic Syndr 2006; 43 (5): 509-515
    • (2006) J Acquir Immune Defic Syndr , vol.43 , Issue.5 , pp. 509-515
    • Markowitz, M.1    Morales-Ramirez, J.O.2    Nguyen, B.Y.3
  • 37
    • 70149119217 scopus 로고    scopus 로고
    • Raltegravir cerebrospinal fluid concentrations in HIV-1 infection
    • Yilmaz A, Gisslen M, Spudich S, et al. Raltegravir cerebrospinal fluid concentrations in HIV-1 infection. PLoS One 2009; 4 (9): e6877
    • (2009) PLoS One , vol.4 , Issue.9
    • Yilmaz, A.1    Gisslen, M.2    Spudich, S.3
  • 38
    • 77949921791 scopus 로고    scopus 로고
    • Pharmacokinetic (PK), safety, and efficacy data on cohort IIA; Youth aged 6 to 11 years from IMPAACT P1066: A phase I/II study to evaluate raltegravir (RAL) in HIV-1 infected youth [abstract no. 873]
    • Feb 16-19; San Francisco (CA)
    • Nachman S, Samson P, Acosta E, et al. Pharmacokinetic (PK), safety, and efficacy data on cohort IIA; youth aged 6 to 11 years from IMPAACT P1066: a phase I/II study to evaluate raltegravir (RAL) in HIV-1 infected youth [abstract no. 873]. 17th Conference on Retro-viruses and opportunistic Infections; 2010 Feb 16-19; San Francisco (CA)
    • (2010) 17th Conference on Retro-viruses and Opportunistic Infections
    • Nachman, S.1    Samson, P.2    Acosta, E.3
  • 39
    • 67349217885 scopus 로고    scopus 로고
    • Pharmacokinetics of raltegravir in individuals with UGT1A1 polymorphisms
    • Jun
    • Wenning LA, Petry AS, Kost JT, et al. Pharmacokinetics of raltegravir in individuals with UGT1A1 polymorphisms. Clin Pharmacol Ther 2009 Jun; 85 (6): 623-627
    • (2009) Clin Pharmacol Ther , vol.85 , Issue.6 , pp. 623-627
    • Wenning, L.A.1    Petry, A.S.2    Kost, J.T.3
  • 40
    • 37349120701 scopus 로고    scopus 로고
    • Antiretroviral therapy with the integrase inhibitor raltegravir alters decay kinetics of HIV, significantly reducing the second phase
    • Nov12
    • Murray JM, Emery S, Kelleher AD, et al. Antiretroviral therapy with the integrase inhibitor raltegravir alters decay kinetics of HIV, significantly reducing the second phase. AIDS 2007 Nov 12; 21 (17): 2315-2321
    • (2007) AIDS , vol.21 , Issue.17 , pp. 2315-2321
    • Murray, J.M.1    Emery, S.2    Kelleher, A.D.3
  • 41
    • 77950013808 scopus 로고    scopus 로고
    • Merck and Co. Inc. A study to evaluate the safety and efficacy of an investigational drug in HIV infected patients [ClinicalTrials.gov identifier NCT00100048]. US National Institutes of Health ClinicalTrials.gov [online] [Accessed 2010 Feb 3]
    • Merck and Co. Inc. A study to evaluate the safety and efficacy of an investigational drug in HIV infected patients [ClinicalTrials.gov identifier NCT00100048]. US National Institutes of Health ClinicalTrials.gov [online]. Available from URL http://clinicaltrials.gov [Accessed 2010 Feb 3]


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