-
1
-
-
77949935075
-
-
Joint United Nations Programme on HIV/AIDS. 2009 AIDS epidemic update [online] [Accessed 2009 Dec 21]
-
Joint United Nations Programme on HIV/AIDS. 2009 AIDS epidemic update [online]. Available from URL http://data. unaids.org/pub/Report/2009/2009- epidemic-update-en.pdf [Accessed 2009 Dec 21].
-
-
-
-
2
-
-
77949950716
-
-
WHO UNAIDS UNICEF. Towards universal access: scaling up priority HIV/AIDS interventions in the health sector: progress report 2008 [online] [Accessed 2008 Nov 26]
-
WHO, UNAIDS, UNICEF. Towards universal access: scaling up priority HIV/AIDS interventions in the health sector: progress report 2008 [online]. Available from URL: http://www.who.int/hiv/pub/towards-universal-access-report- 2008.pdf [Accessed 2008 Nov 26]
-
-
-
-
3
-
-
77949991209
-
-
WHO. Global HIV prevalence has levelled off: improvements in surveillance increase understanding of the epidemic, resulting in substantial revisions to estimates [online] [Accessed 2008 Nov 26]
-
WHO. Global HIV prevalence has levelled off: improvements in surveillance increase understanding of the epidemic, resulting in substantial revisions to estimates [online]. Available from URL http://www.who.int/mediacentre/news/ releases/2007/pr61/en/print.html [Accessed 2008 Nov 26]
-
-
-
-
4
-
-
47949131197
-
HIV integrase inhibitors: Out of the pipeline and into the clinic
-
Jul 24
-
Havlir DV. HIV integrase inhibitors: out of the pipeline and into the clinic. N Engl J Med 2008 Jul 24; 359 (4): 416-418
-
(2008)
N Engl J Med
, vol.359
, Issue.4
, pp. 416-418
-
-
Havlir, D.V.1
-
5
-
-
0037124139
-
Guidelines for using antiretroviral agents among HIV-infected adults and adolescents: Recommendations of the Panel on Clinical Practices for Treatment of HIV
-
May 17
-
Dybul M, Fauci AS, Bartlett JG, et al. Guidelines for using antiretroviral agents among HIV-infected adults and adolescents: recommendations of the Panel on Clinical Practices for Treatment of HIV. MMWR Recomm Rep 2002 May 17; 51 (RR-7): 1-55
-
(2002)
MMWR Recomm Rep
, vol.51
, Issue.RR-7
, pp. 1-55
-
-
Dybul, M.1
Fauci, A.S.2
Bartlett, J.G.3
-
6
-
-
33646812239
-
Tracking the prevalence of transmitted antiretroviral drug-resistant HIV-1
-
Shet A, Berry L, Mohri H, et al. Tracking the prevalence of transmitted antiretroviral drug-resistant HIV-1. J Acquir Immune Defic Syndr 2006; 41 (4): 439-446
-
(2006)
J Acquir Immune Defic Syndr
, vol.41
, Issue.4
, pp. 439-446
-
-
Shet, A.1
Berry, L.2
Mohri, H.3
-
7
-
-
3142660152
-
The prevalence of antiretroviral drug resistance in the United States
-
Richman D, Morton S, Wrin T, et al. The prevalence of antiretroviral drug resistance in the United States. AIDS 2004; 18 (10): 1393-1401
-
(2004)
AIDS
, vol.18
, Issue.10
, pp. 1393-1401
-
-
Richman, D.1
Morton, S.2
Wrin, T.3
-
8
-
-
65249180642
-
Emerging pharmacology: Inhibitors of human immunodeficiency virus integration
-
Hazuda D, Iwamoto M, Wenning L. Emerging pharmacology: inhibitors of human immunodeficiency virus integration. Annu Rev Pharmacol Toxicol 2009; 49: 377-394
-
(2009)
Annu Rev Pharmacol Toxicol
, vol.49
, pp. 377-394
-
-
Hazuda, D.1
Iwamoto, M.2
Wenning, L.3
-
9
-
-
77949965315
-
-
DHSS Panel on Antiretroviral Guidelines for Adults and Adolescents: a working group of the Office of AIDS Research Advisory Council (OARAC). Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents [online] [Accessed 2010 Jan 20]
-
DHSS Panel on Antiretroviral Guidelines for Adults and Adolescents: a working group of the Office of AIDS Research Advisory Council (OARAC). Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents [online]. Available from URL http://aidsinfo.nih.gov/contentfiles/ AdultandAdolescentGL.pdf [Accessed 2010 Jan 20]
-
-
-
-
10
-
-
48949097660
-
Antiretroviral treatment of adult HIV infection 2008 recommendations of the International AIDS Society-USA panel
-
Hammer SM, Eron Jr JJ, Reiss P. Antiretroviral treatment of adult HIV infection: 2008 recommendations of the International AIDS Society-USA panel. JAMA 2008; 300 (5): 555-570
-
(2008)
JAMA
, vol.300
, Issue.5
, pp. 555-570
-
-
Hammer, S.M.1
Eron Jr., J.J.2
Reiss, P.3
-
11
-
-
52749083531
-
British HIV Association guidelines for the treatment of HIV-1-infected adults with antiretroviral therapy 2008
-
Gazzard BG. British HIV Association guidelines for the treatment of HIV-1-infected adults with antiretroviral therapy 2008. HIV Med 2008; 9 (8): 563-608
-
(2008)
HIV Med
, vol.9
, Issue.8
, pp. 563-608
-
-
Gazzard, B.G.1
-
12
-
-
77950015721
-
-
European AIDS Clinical Society (EACS). Guidelines for the clinical management and treatment of HIV infected adults in Europe [online] [Accessed 2010 Jan 20]
-
European AIDS Clinical Society (EACS). Guidelines for the clinical management and treatment of HIV infected adults in Europe [online]. Available from URL http://europeanaidsclinicalsociety.org/guidelinespdf/1-Treatment-of- HIV-Infected-Adults.pdf [Accessed 2010 Jan 20]
-
-
-
-
13
-
-
70149095523
-
Primary care guidelines for the management of persons infected with human immunodeficiency virus 2009 update by the HIV Medicine Association of the Infectious Diseases Society of America
-
Adberg JA, Kaplan JE, Libman H, et al. Primary care guidelines for the management of persons infected with human immunodeficiency virus: 2009 update by the HIV Medicine Association of the Infectious Diseases Society of America. Clin Infect Dis 2009; 49 (5): 651-681
-
(2009)
Clin Infect Dis
, vol.49
, Issue.5
, pp. 651-681
-
-
Adberg, J.A.1
Kaplan, J.E.2
Libman, H.3
-
16
-
-
66949136295
-
Raltegravir: A review of its use in the management of HIV infection in treatment-experienced patients
-
Croxtall JD, Keam SJ. Raltegravir: a review of its use in the management of HIV infection in treatment-experienced patients. Drugs 2009; 69 (8): 1059-1075
-
(2009)
Drugs
, vol.69
, Issue.8
, pp. 1059-1075
-
-
Croxtall, J.D.1
Keam, S.J.2
-
17
-
-
33947715164
-
Role of integrase inhibitors in the treatment of HIV disease: Expert review of anti-infective therapy
-
Palmisano L. Role of integrase inhibitors in the treatment of HIV disease: expert review of anti-infective therapy. Expert Rev Anti Infect Ther 2007; 5 (1): 67-75
-
(2007)
Expert Rev Anti Infect Ther
, vol.5
, Issue.1
, pp. 67-75
-
-
Palmisano, L.1
-
18
-
-
52449097240
-
Discovery of raltegravir, a potent, selective orally bioavailable HIV-integrase inhibitor for the treatment of HIV-AIDS infection
-
Summa V, Petrocchi A, Bonelli F, et al. Discovery of raltegravir, a potent, selective orally bioavailable HIV-integrase inhibitor for the treatment of HIV-AIDS infection. J Med Chem 2008; 51 (18): 5843-5855
-
(2008)
J Med Chem
, vol.51
, Issue.18
, pp. 5843-5855
-
-
Summa, V.1
Petrocchi, A.2
Bonelli, F.3
-
19
-
-
54049102468
-
Drug resistance profiles for the HIV integrase gene in patients failing raltegravir salvage therapy
-
Charpentier C, Karmochkine M, Laureillard D, et al. Drug resistance profiles for the HIV integrase gene in patients failing raltegravir salvage therapy. HIV Med 2008; 9 (9): 765-770
-
(2008)
HIV Med
, vol.9
, Issue.9
, pp. 765-770
-
-
Charpentier, C.1
Karmochkine, M.2
Laureillard, D.3
-
20
-
-
67149113903
-
Constraints on the dominant mechanism for HIV viral dynamics in patients on raltegravir
-
Sedaghat AR, Siliciano RF, Wilke CO. Constraints on the dominant mechanism for HIV viral dynamics in patients on raltegravir. Antivir Ther 2009; 14 (2): 263-271
-
(2009)
Antivir Ther
, vol.14
, Issue.2
, pp. 263-271
-
-
Sedaghat, A.R.1
Siliciano, R.F.2
Wilke, C.O.3
-
21
-
-
62349120391
-
Dynamic patterns of human immunodeficiency virus type 1 integrase gene evolution in patients failing raltegravir-based salvage therapies
-
Feb 20
-
Canducci F, Sampaolo M, Marinozzi MC, et al. Dynamic patterns of human immunodeficiency virus type 1 integrase gene evolution in patients failing raltegravir-based salvage therapies. AIDS 2009 Feb 20; 23 (No.4): 455-460
-
(2009)
AIDS
, vol.23
, Issue.4
, pp. 455-460
-
-
Canducci, F.1
Sampaolo, M.2
Marinozzi, M.C.3
-
22
-
-
62549166235
-
Quasispecies variant dynamics during emergence of resistance to raltegravir in HIV-1-infected patients
-
Apr 1
-
Malet I, Delelis O, Soulie C, et al. Quasispecies variant dynamics during emergence of resistance to raltegravir in HIV-1-infected patients. J Antimicrob Chemother 2009 Apr 1; 63 (4): 795-804
-
(2009)
J Antimicrob Chemother
, vol.63
, Issue.4
, pp. 795-804
-
-
Malet, I.1
Delelis, O.2
Soulie, C.3
-
23
-
-
70350666377
-
Loss of raltegravir susceptibility of HIV-1 is conferred by multiple non-overlapping genetic pathways
-
Fransen S, Gupta S, Danovich R, et al. Loss of raltegravir susceptibility of HIV-1 is conferred by multiple non-overlapping genetic pathways. J Virol 2009; 83 (22): 11440-11446
-
(2009)
J Virol
, vol.83
, Issue.22
, pp. 11440-11446
-
-
Fransen, S.1
Gupta, S.2
Danovich, R.3
-
24
-
-
70349337790
-
Longitudinal analysis of raltegravir susceptibility and integrase replication capacity of human immunodeficiency virus type 1 during virologic failure
-
Oct
-
Fransen S, Karmochkine M, Huang W, et al. Longitudinal analysis of raltegravir susceptibility and integrase replication capacity of human immunodeficiency virus type 1 during virologic failure. Antimicrob Agents Chemother 2009 Oct; 53 (10): 4522-4524
-
(2009)
Antimicrob Agents Chemother
, vol.53
, Issue.10
, pp. 4522-4524
-
-
Fransen, S.1
Karmochkine, M.2
Huang, W.3
-
25
-
-
70350156722
-
The dynamics of appearance and disappearance of HIV-1 integrase mutations during and after withdrawal of raltegravir therapy
-
Ferns RB, Kirk S, Bennett J, et al. The dynamics of appearance and disappearance of HIV-1 integrase mutations during and after withdrawal of raltegravir therapy. AIDS 2009; 23 (16): 2159-2164
-
(2009)
AIDS
, vol.23
, Issue.16
, pp. 2159-2164
-
-
Ferns, R.B.1
Kirk, S.2
Bennett, J.3
-
26
-
-
73649137500
-
The HIV-1 integrase genotype strongly predicts raltegravir susceptibility but not viral fitness of primary virus isolates
-
Buzon MJ, Dalmau J, Puertas MC, et al. The HIV-1 integrase genotype strongly predicts raltegravir susceptibility but not viral fitness of primary virus isolates. AIDS 2009; 24 (1): 17-25
-
(2009)
AIDS
, vol.24
, Issue.1
, pp. 17-25
-
-
Buzon, M.J.1
Dalmau, J.2
Puertas, M.C.3
-
27
-
-
67249085974
-
Evolution of raltegravir resistance during therapy
-
Jul
-
Sichtig N, Sierra S, Kaiser R, et al. Evolution of raltegravir resistance during therapy. J Antimicrob Chemother 2009 Jul; 64 (1): 25-32
-
(2009)
J Antimicrob Chemother
, vol.64
, Issue.1
, pp. 25-32
-
-
Sichtig, N.1
Sierra, S.2
Kaiser, R.3
-
28
-
-
34748860363
-
Rapid and durable antiretroviral effect of the HIV-1 integrase inhibitor raltegravir as part combination therapy in treatment-naive patients with HIV-1 infection
-
Markowitz M, Nguyen B-Y, Gotuzzo E, et al. Rapid and durable antiretroviral effect of the HIV-1 integrase inhibitor raltegravir as part combination therapy in treatment-naive patients with HIV-1 infection. J Acquir Immune Defic Syndr 2007; 46 (2): 125-133
-
(2007)
J Acquir Immune Defic Syndr
, vol.46
, Issue.2
, pp. 125-133
-
-
Markowitz, M.1
Nguyen, B.-Y.2
Gotuzzo, E.3
-
29
-
-
70350558421
-
Sustained antiretroviral effect of raltegravir after 96 weeks of combination therapy in treatment-naive patients with HIV-1 infection
-
Nov
-
Markowitz M, Nguyen BY, Gotuzzo E, et al. Sustained antiretroviral effect of raltegravir after 96 weeks of combination therapy in treatment-naive patients with HIV-1 infection. J Acquir Immune Defic Syndr 2009 Nov; 52 (3): 350-356
-
(2009)
J Acquir Immune Defic Syndr
, vol.52
, Issue.3
, pp. 350-356
-
-
Markowitz, M.1
Nguyen, B.Y.2
Gotuzzo, E.3
-
30
-
-
69449101785
-
Safety and efficacy of raltegravir-based versus efavirenz-based combination therapy in treatment-naive patients with HIV-1 infection: A multicentre, double-blind randomised controlled trial
-
Sep 5
-
Lennox JL, DeJesus E, Lazzarin A, et al. Safety and efficacy of raltegravir-based versus efavirenz-based combination therapy in treatment-naive patients with HIV-1 infection: a multicentre, double-blind randomised controlled trial. Lancet 2009 Sep 5; 374 (9692): 796-806
-
(2009)
Lancet
, vol.374
, Issue.9692
, pp. 796-806
-
-
Lennox, J.L.1
Dejesus, E.2
Lazzarin, A.3
-
31
-
-
77953913027
-
Raltegravir demonstrates durable efficacy through 96 weeks: Results from STARTMRK a phase III study of raltegravir-based vs. efavirenz-based therapy in treatment-naive HIV+ patients [abstract no. H-924b]
-
Sep 12; San Francisco (CA)
-
Lennox J, De Jesus E, Lazzarin A, et al. Raltegravir demonstrates durable efficacy through 96 weeks: results from STARTMRK, a phase III study of raltegravir-based vs. efavirenz-based therapy in treatment-naive HIV+ patients [abstract no. H-924b]. 49th Interscience Conference on Antimicrobial Agents and Chemotherapy; 2009 Sep 12; San Francisco (CA)
-
(2009)
49th Interscience Conference on Antimicrobial Agents and Chemotherapy
-
-
Lennox, J.1
De Jesus, E.2
Lazzarin, A.3
-
32
-
-
77949958735
-
-
Merck and Co. Inc. Isentress (raltegravir) US prescribing information. Whitehouse Station (NJ): Merck and Co. Inc., 2009
-
Merck and Co. Inc. Isentress (raltegravir): US prescribing information. Whitehouse Station (NJ): Merck and Co. Inc., 2009
-
-
-
-
33
-
-
77949962065
-
-
European Medicines Agency. Raltegravir: summary of product characteristics [online] [Accessed 2009 Dec 4]
-
European Medicines Agency. Raltegravir: summary of product characteristics [online]. Available from URL: http://www.emea.europa.eu/ humandocs/PDFs/EPAR/isentress/emea-combined-h860en.pdf [Accessed 2009 Dec 4]
-
-
-
-
34
-
-
44049105253
-
Raltegravir thorough QT/QTc study: A single supratherapeutic dose of raltegravir does not prolong the QTcF interval
-
Iwamoto M, Kost JT, Mistry GC, et al. Raltegravir thorough QT/QTc study: a single supratherapeutic dose of raltegravir does not prolong the QTcF interval. J Clin Pharmacol 2008; 48 (6): 726-733
-
(2008)
J Clin Pharmacol
, vol.48
, Issue.6
, pp. 726-733
-
-
Iwamoto, M.1
Kost, J.T.2
Mistry, G.C.3
-
35
-
-
34548065793
-
Metabolism and disposition in humans of raltegravir (MK-0518), an anti-AIDS drug targeting the HIV-1 integrase enzyme
-
Kassahun K, McIntosh I, Cui D, et al. Metabolism and disposition in humans of raltegravir (MK-0518), an anti-AIDS drug targeting the HIV-1 integrase enzyme. Drug Metab Dispos 2007; 35 (9): 1657-1663
-
(2007)
Drug Metab Dispos
, vol.35
, Issue.9
, pp. 1657-1663
-
-
Kassahun, K.1
McIntosh, I.2
Cui, D.3
-
36
-
-
33845366857
-
Antiretroviral activity, pharmacokinetics, and tolerability of MK-0518, a novel inhibitor of HIV-1 integrase, dosed as monotherapy for 10 days in treatment-naive HIV-1-infected individuals
-
Markowitz M, Morales-Ramirez JO, Nguyen BY, et al. Antiretroviral activity, pharmacokinetics, and tolerability of MK-0518, a novel inhibitor of HIV-1 integrase, dosed as monotherapy for 10 days in treatment-naive HIV-1-infected individuals. J Acquir Immune Defic Syndr 2006; 43 (5): 509-515
-
(2006)
J Acquir Immune Defic Syndr
, vol.43
, Issue.5
, pp. 509-515
-
-
Markowitz, M.1
Morales-Ramirez, J.O.2
Nguyen, B.Y.3
-
37
-
-
70149119217
-
Raltegravir cerebrospinal fluid concentrations in HIV-1 infection
-
Yilmaz A, Gisslen M, Spudich S, et al. Raltegravir cerebrospinal fluid concentrations in HIV-1 infection. PLoS One 2009; 4 (9): e6877
-
(2009)
PLoS One
, vol.4
, Issue.9
-
-
Yilmaz, A.1
Gisslen, M.2
Spudich, S.3
-
38
-
-
77949921791
-
Pharmacokinetic (PK), safety, and efficacy data on cohort IIA; Youth aged 6 to 11 years from IMPAACT P1066: A phase I/II study to evaluate raltegravir (RAL) in HIV-1 infected youth [abstract no. 873]
-
Feb 16-19; San Francisco (CA)
-
Nachman S, Samson P, Acosta E, et al. Pharmacokinetic (PK), safety, and efficacy data on cohort IIA; youth aged 6 to 11 years from IMPAACT P1066: a phase I/II study to evaluate raltegravir (RAL) in HIV-1 infected youth [abstract no. 873]. 17th Conference on Retro-viruses and opportunistic Infections; 2010 Feb 16-19; San Francisco (CA)
-
(2010)
17th Conference on Retro-viruses and Opportunistic Infections
-
-
Nachman, S.1
Samson, P.2
Acosta, E.3
-
39
-
-
67349217885
-
Pharmacokinetics of raltegravir in individuals with UGT1A1 polymorphisms
-
Jun
-
Wenning LA, Petry AS, Kost JT, et al. Pharmacokinetics of raltegravir in individuals with UGT1A1 polymorphisms. Clin Pharmacol Ther 2009 Jun; 85 (6): 623-627
-
(2009)
Clin Pharmacol Ther
, vol.85
, Issue.6
, pp. 623-627
-
-
Wenning, L.A.1
Petry, A.S.2
Kost, J.T.3
-
40
-
-
37349120701
-
Antiretroviral therapy with the integrase inhibitor raltegravir alters decay kinetics of HIV, significantly reducing the second phase
-
Nov12
-
Murray JM, Emery S, Kelleher AD, et al. Antiretroviral therapy with the integrase inhibitor raltegravir alters decay kinetics of HIV, significantly reducing the second phase. AIDS 2007 Nov 12; 21 (17): 2315-2321
-
(2007)
AIDS
, vol.21
, Issue.17
, pp. 2315-2321
-
-
Murray, J.M.1
Emery, S.2
Kelleher, A.D.3
-
41
-
-
77950013808
-
-
Merck and Co. Inc. A study to evaluate the safety and efficacy of an investigational drug in HIV infected patients [ClinicalTrials.gov identifier NCT00100048]. US National Institutes of Health ClinicalTrials.gov [online] [Accessed 2010 Feb 3]
-
Merck and Co. Inc. A study to evaluate the safety and efficacy of an investigational drug in HIV infected patients [ClinicalTrials.gov identifier NCT00100048]. US National Institutes of Health ClinicalTrials.gov [online]. Available from URL http://clinicaltrials.gov [Accessed 2010 Feb 3]
-
-
-
|