Hypoxic preconditioning provides neuroprotection and increases vascular endothelial growth factor A, preserves the phosphorylation of Akt-Ser-473 and diminishes the increase in caspase-3 activity in neonatal rat hypoxic-ischemic model

Brain Research

Volumn 1325, Issue , 2010, Pages 1-9

  Feng, Yangzheng ^a   Rhodes, Philip G ^a   Bhatt, Abhay J ^a  

^a UNIVERSITY OF MISSISSIPPI SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; Hypoxic tolerance; Neuroprotection; Neurotrophin; Newborn rat

Indexed keywords

CASPASE 3; PROTEIN KINASE B; VASCULOTROPIN; VASCULOTROPIN A;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN DAMAGE; BRAIN DEVELOPMENT; BRAIN HYPOXIA; BRAIN ISCHEMIA; BRAIN WEIGHT; CAROTID ARTERY LIGATION; CONTROLLED STUDY; ENZYME ACTIVITY; GENE AMPLIFICATION; GENE INDUCTION; ISCHEMIC PRECONDITIONING; MORPHOLOGY; NEUROPROTECTION; NEWBORN; NONHUMAN; OXYGENATION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RIGHT HEMISPHERE; RNA SPLICING; WEIGHT REDUCTION;

ANIMALS; ANIMALS, NEWBORN; ANOXIA; BRAIN; CAROTID ARTERY DISEASES; CASPASE 3; DISEASE MODELS, ANIMAL; FEMALE; HYPOXIA-ISCHEMIA, BRAIN; MALE; PHOSPHORYLATION; PROTEIN ISOFORMS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; TIME FACTORS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

RATTUS;

EID: 77949918726     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2010.02.029     Document Type: Article

References (35)

1. Adris S., Ojeda E., Genero M., and Argibay P. Quantification of vascular endothelial growth factor and neuropilins mRNAs during rat brain maturation by real-time PCR. Cell. Mol. Neurobiol. 25 (2005) 1035-1041
2. Ashwal S., and Pearce W.J. Animal models of neonatal stroke. Curr. Opin. Pediatr. 13 (2001) 506-516
3. Bergeron M., Gidday J.M., Yu A.Y., Semenza G.L., Ferriero D.M., and Sharp F.R. Role of hypoxia-inducible factor-1 in hypoxia-induced ischemic tolerance in neonatal rat brain. Ann. Neurol. 48 (2000) 285-296
4. Bernaudin M., Tang Y., Reilly M., Petit E., and Sharp F.R. Brain genomic response following hypoxia and re-oxygenation in the neonatal rat. Identification of genes that might contribute to hypoxia-induced ischemic tolerance. J. Biol. Chem. 277 (2002) 39728-39738
5. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72 (1976) 248-254
6. Cataltepe O., Vannucci R.C., Heitjan D.F., and Towfighi J. Effect of status epilepticus on hypoxic-ischemic brain damage in the immature rat. Pediatr. Res. 38 (1995) 251-257
7. Feng Y., Fratkins J.D., and LeBlanc M.H. Treatment with tamoxifen reduces hypoxic-ischemic brain injury in neonatal rats. Eur. J. Pharmacol. 484 (2004) 65-74
8. Feng Y., Rhodes P.G., and Bhatt A.J. Neuroprotective effects of vascular endothelial growth factor following hypoxic ischemic brain injury in neonatal rats. Pediatr. Res. 64 (2008) 370-374
9. Feng Y., Rhodes P.G., Liu H., and Bhatt A.J. Dexamethasone induces neurodegeneration but also up-regulates vascular endothelial growth factor A in neonatal rat brains. Neuroscience 158 (2009) 823-832
10. Franke T.F., Kaplan D.R., and Cantley L.C. PI3K: downstream AKTion blocks apoptosis. Cell 88 (1997) 435-437
11. Franke T.F., Hornik C.P., Segev L., Shostak G.A., and Sugimoto C. PI3K/Akt and apoptosis: size matters. Oncogene 22 (2003) 8983-8998
12. Gerber H.P., McMurtrey A., Kowalski J., Yan M., Keyt B.A., Dixit V., and Ferrara N. Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3′-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activation. J. Biol. Chem. 273 (1998) 30336-30343
13. Gidday J.M., Fitzgibbons J.C., Shah A.R., and Park T.S. Neuroprotection from ischemic brain injury by hypoxic preconditioning in the neonatal rat. Neurosci. Lett. 168 (1994) 221-224
14. Goldberg-Cohen I., Furneauxb H., and Levy A.P. A 40-bp RNA element that mediates stabilization of vascular endothelial growth factor mRNA by HuR. J. Biol. Chem. 277 (2002) 13635-13640
15. Gustavsson M., Anderson M.F., Mallard C., and Hagberg H. Hypoxic preconditioning confers long-term reduction of brain injury and improvement of neurological ability in immature rats. Pediatr. Res. 57 (2005) 305-309
16. Gustavsson M., Wilson M.A., Mallard C., Rousset C., Johnston M.V., and Hagberg H. Global gene expression in the developing rat brain after hypoxic preconditioning: involvement of apoptotic mechanisms?. Pediatr. Res. 61 (2007) 444-450
17. Huang Y.F., Zhuang S.Q., Chen D.P., Liang Y.J., and Li X.Y. Angiogenesis and its regulatory factors in brain tissue of neonatal rat hypoxic-ischemic encephalopathy. Zhonghua Er Ke Za Zhi 42 (2004) 210-214
18. Jin K.L., Mao X.O., and Greenberg D.A. Vascular endothelial growth factor: direct neuroprotective effect in in vitro ischemia. Proc. Natl. Acad. Sci. U. S. A. 97 (2000) 10242-10247
19. Jones N.M., and Bergeron M. Hypoxic preconditioning induces changes in HIF-1 target genes in neonatal rat brain. J. Cereb. Blood Flow Metab. 21 (2001) 1105-1114
20. Kaya D., Gursoy-Ozdemir Y., Yemisci M., Tuncer N., Aktan S., and Dalkara T. VEGF protects brain against focal ischemia without increasing blood-brain permeability when administered intracerebroventricularly. J. Cereb. Blood Flow Metab. 25 (2005) 1111-1118
21. Kilic U., Kilic E., Jarve A., Guo Z., Spudich A., Bieber K., Barzena U., Bassetti C.L., Marti H.H., and Hermann D.M. Human vascular endothelial growth factor protects axotomized retinal ganglion cells in vivo by activating ERK-1/2 and Akt pathways. J. Neurosci. 26 (2006) 12439-12446
22. Konstantinidou A.E., Givalos N., Gakiopoulou H., Korkolopoulou P., Kotsiakis X., Boviatsis E., Agrogiannis G., Mahera H., and Patsouris E. Caspase-3 immunohistochemical expression is a marker of apoptosis, increased grade and early recurrence in intracranial meningiomas. Apoptosis 12 (2007) 695-705
23. Laudenbach V., Fontaine R.H., Medja F., Carmeliet P., Hicklin D.J., Gallego J., Leroux P., Marret S., and Gressens P. Neonatal hypoxic preconditioning involves vascular endothelial growth factor. Neurobiol. Dis. 26 (2007) 243-252
24. Lee H.T., Chang Y.C., Tu Y.F., and Huang C.C. VEGF-A/VEGFR-2 signaling leading to cAMP response element-binding protein phosphorylation is a shared pathway underlying the protective effect of preconditioning on neurons and endothelial cells. J. Neurosci. 29 (2009) 4356-4368
25. Livak K.J., and Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25 (2001) 402-408
26. McColm J.R., Geisen P., and Hartnett M.E. VEGF isoforms and their expression after a single episode of hypoxia or repeated fluctuations between hyperoxia and hypoxia: relevance to clinical ROP. Mol. Vis. 10 (2004) 512-520
27. Neufeld G., Cohen T., Gengrinovitch S., and Poltorak Z. Vascular endothelial growth factor (VEGF) and its receptors. FASEB J. 13 (1999) 9-22
28. Palmer C., Vannucci R.C., and Towfighi J. Reduction of perinatal hypoxic-ischemic brain damage with allopurinol. Pediatr. Res. 27 (1990) 332-336
29. Rice J.E., Vannucci R.C., and Brierley J.B. The influence of immaturity on hypoxic-ischemic brain damage in the rat. Ann. Neurol. 9 (1981) 131-141
30. Stein I., Itin A., Einat P., Skaliter R., Grossman Z., and Keshet E. Translation of vascular endothelial growth factor mRNA by internal ribosome entry: implications for translation under hypoxia. Mol. Cell. Biol. 18 (1998) 3112-3119
31. Vannucci R.C., Towfighi J., and Vannucci S.J. Hypoxic preconditioning and hypoxic-ischemic brain damage in the immature rat: pathologic and metabolic correlates. J. Neurochem. 71 (1998) 1215-1220
32. Wick A., Wick W., Waltenberger J., Weller M., Dichgans J., and Schulz J.B. Neuroprotection by hypoxic preconditioning requires sequential activation of vascular endothelial growth factor receptor and Akt. J. Neurosci. 22 (2002) 6401-6407
33. Yin W., Signore A.P., Iwai M., Cao G., Gao Y., Johnnides M.J., Hickey R.W., and Chen J. Preconditioning suppresses inflammation in neonatal hypoxic ischemia via Akt activation. Stroke 38 (2007) 1017-1024
34. Zhang L., Conejo-Garcia J.R., Yang N., Huang W., Mohamed-Hadley A., Yao W., Benencia F., and Coukos G. Different effects of glucose starvation on expression and stability of VEGF mRNA isoforms in murine ovarian cancer cells. Biochem. Biophys. Res. Commun. 292 (2002) 860-868
35. Zhao H., Shimohata T., Wang J.Q., Sun G., Schaal D.W., Sapolsky R.M., and Steinberg G.K. Akt contributes to neuroprotection by hypothermia against cerebral ischemia in rats. J. Neurosci. 25 (2005) 9794-9806