Synthesis and properties of biodegradable thermo- and pH-sensitive poly[(N-isopropylacrylamide)-co-(methacrylic acid)] hydrogels

Polymer Degradation and Stability

Volumn 95, Issue 5, 2010, Pages 719-724

  Zhao, San Ping ^a   Cao, Meng Jie ^a   Li, Li Yan ^a   Xu, Wei Lin ^a  

^a BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

Author keywords

Copolymerization; Drug delivery; Hydrolytic degradation; pH sensitivity; Temperature sensitivity

Indexed keywords

CROSSLINKED; CROSSLINKER; DEGRADATION RATE; HYDROLYTIC DEGRADATION; METHACRYLIC ACIDS; N-ISOPROPYLACRYLAMIDES; PBS SOLUTION; PH SENSITIVE; PH SENSITIVITY; PH-SENSITIVE HYDROGEL; POTENTIAL APPLICATIONS; RELEASE RATE; SMART DRUG DELIVERY SYSTEMS; SWELLING MEASUREMENTS; TEMPERATURE DEPENDENCE; TEMPERATURE SENSITIVITY; UV IRRADIATION;

ACIDS; ACRYLIC MONOMERS; AMIDES; BODY FLUIDS; COPOLYMERIZATION; CROSSLINKING; DRUG DELIVERY; PH SENSORS; PHOTODEGRADATION; POLYETHYLENE GLYCOLS; POLYETHYLENE OXIDES; POTENTIOMETRIC SENSORS; SYNTHESIS (CHEMICAL);

HYDROGELS;

EID: 77949915705     PISSN: 01413910     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.polymdegradstab.2010.02.027     Document Type: Article

References (28)

1. Chen G., and Hoffman A.S. Graft copolymers that exhibit temperature-induced phase transitions over a wide range of pH. Nature 373 (1995) 49-52
2. Katalin K., Erzsebet W., Erik G., and Krisztina L. Distribution of phenols in thermoresponsive hydrogels. Macromolecules 40 (2007) 2141-2147
3. Wang K., Fu S.Z., Gu Y.C., Xu X., Dong P.W., Guo G., et al. Synthesis and characterization of biodegradable pH-sensitive hydrogels based on poly(ε-caprolactone), methacrylic acid, and poly(ethylene glycol). Polym Degrad Stab 94 (2009) 730-737
4. Tanaka T., Nishio I., Sun S.T., and Ueno-Nishio S. Collapse of gels in an electric field. Science 218 (1982) 467-469
5. Suzuki A., and Tanaka T. Phase transition in polymer gels induced by visible light. Nature 346 (1990) 345-347
6. Torres L.M., and Peppas N.A. Molecular design and in vitro studies of novel pH sensitive hydrogels for the oral delivery of calcitonin. Macromolecules 32 (1999) 6646-6651
7. Kost J., and Langer R. Responsive polymeric delivery systems. Adv Drug Del Rev 46 (2001) 125-148
8. Neradovic D., Hinrichs W., Kettenes-van J., van Nostrum C., and Hennick W. Poly(N-isopropylacrylamide) with hydrolyzable lactic acid ester side groups: a new type of thermosensitive polymer suitable for drug delivery purposes. J Controlled Release 72 (2001) 252-253
9. Lowe T.L., Virtanen J., and Tenhu H. Interactions of drugs and spin probes with hydrophobically modified polyelectrolyte hydrogels based on N-isopropylacrylamide. Polymer 40 (1999) 2595-2603
10. Kuckling D., Adler H.J.P., Arndt K.F., Ling L., and Habicher W.D. Temperature and pH dependent solubility of novel poly(N-isopropylacrylamide)-copolymers. Macromol Chem Phys 201 (2000) 273-280
11. Aslam K. Preparation and characterization of N-isopropylacrylamide/acrylic acid copolymer core-shell microgel particles. J Colloid Interface Sci 313 (2007) 697-704
12. You H.B., Teruo O., and Sung W.K. Temperature dependence of swelling of crosslinked poly(N, N′-alkyl substituted acrylamides) in water. J Polym Sci Part B Pol Phys 28 (1990) 923-936
13. Chen G.H., and Hoffman A.S. Temperature-induced phase transition behaviors of random vs. graft copolymers of N-isopropylacrylamide and acrylic acid. Macromol Rapid Commun 16 (1995) 175-182
14. Bulmus V., Ding Z., Long C.J., Stayton P.S., and Hoffman A.S. Site-specific polymer-streptavidin bioconjugate for pH-controlled binding and triggered release of biotin. Bioconjug Chem 11 (2000) 78-83
15. Xiao Y., Xu W., Zhu Q., Yan B., Yang D., Yang J., et al. Preparation and characterization of a novel pachyman-based pharmaceutical aid. II: a pH-sensitive, biodegradable and biocompatible hydrogel for controlled release of protein drugs. Carbohyd Polym 77 (2009) 612-620
16. Zhang X.Z., Yang Y.Y., Wang F.J., and Chung T.S. Thermosensitive poly(N-isopropylacrylamide-co-acrylic acid) hydrogels with expanded network structures and improved oscillating swelling-deswelling properties. Langmuir 18 (2002) 2013-2018
17. Qiu Y., and Park K. Environment-sensitive hydrogels for drug delivery. Adv Drug Del Rev 53 (2001) 321-339
18. Lin C.C., and Metters A. Enhanced protein delivery from photopolymerized hydrogels using a pseudospecific metal chelating ligand. Pharm Res 23 (2006) 614-622
19. Burdick J.A., Mason M.N., Hinman A.D., Thorne K., and Anseth K.S. Delivery of osteoinductive growth factors from degradable PEG hydrogels influences osteoblast differentiation and mineralization. J Controlled Release 83 (2002) 53-63
20. Hiemstra C., Zhou W., Zhong Z., Wouters M., and Feijen J. Rapidly in situ forming biodegradable robust hydrogels by combining stereocomplexation and photopolymerization. J Am Chem Soc 129 (2007) 9918-9926
21. Zhao S.P., Cao M.J., Li H., Li L.Y., and Xu W.L. Synthesis and characterization of thermo-sensitive semi-IPN hydrogels based on poly(ethylene glycol)-co-poly(ε-caprolactone) macromer, N-isopropylacrylamide, and sodium alginate. Carbohydr Res 345 (2010) 425-431
22. Li X., Wu W., and Liu W. Synthesis and properties of thermo-responsive guar gum/poly(N-isopropylacrylamide) interpenetrating polymer network hydrogels. Carbohydr Polym 71 (2008) 39-402
23. Kokufuta E., Wang B., Yoshida R., Khokhlov A.R., and Hirata M. Volume phase transition of polyelectrolyte gels with different charge distributions. Macromolecules 31 (1998) 6878-6884
24. Lee W.F., and Shieh C.H. pH-thermoreversible hydrogels. II. Synthesis and swelling behaviors of N-isopropylacrylamide-co-acrylic acid-co-sodium acrylate hydrogels. J Appl Polym Sci 73 (1999) 1955-1967
25. Beltran S., Bakai J.P., Hooper H.H., Blanch H.W., and Prausnitz M. Swelling equilibria for weakly ionizable, temperature-sensitive hydrogels. Macromolecules 24 (1991) 549-551
26. Liu Y.Y., and Fan X.D. Synthesis and characterization of pH- and temperature-sensitive hydrogel of N-isopropylacrylamide/cyclodextrin based copolymer. Polymer 43 (2002) 4997-5003
27. Zhang J., and Nicholas A. Synthesis and characterization of pH- and temperature-sensitive poly(methacrylic acid)/poly(N-isopropylacrylamide) interpenetrating polymeric networks. Macromolecules 33 (2000) 102-107
28. Metters A.T., Anseth K.S., and Bowman C.N. Fundamental studies of a novel, biodegradable PEG-b-PLA hydrogel. Polymer 41 (2000) 3993-4004