Synthesis of new 4,5-3(2H)pyridazinone derivatives and their cardiotonic, hypotensive, and platelet aggregation inhibition activities

Archives of Pharmacal Research

Volumn 33, Issue 1, 2010, Pages 25-46

  Amin, Enas Nashaat ^a   Abdel Alim, Abdel Alim M ^a   Abdel Moty, Samia G ^a   El Shorbagi, Abdel Naser A ^a   Abdel Rahman, Mahran Sh ^b  

^a Assiut University Faculty of Medicine   (Egypt)

^b Assiut University   (Egypt)

Author keywords

4,5 dihydropyridazinones; Acute toxicity; Hypotensive; Pharmacophore models; Platelet aggregation inhibition; Positive inotropic (Cardiotonic)

Indexed keywords

4,5 DIHYDRO 3(2H)PYRADAZINONE DERIVATIVE; 6 (4 AMINOPHENYL) 4,5 DIHYDRO 3(2H) PYRIDAZINONE; 6 [4 [(3,5 DIMETHYL 1 (UN)SUBSTITUTED 4 PYRAZOLYLAZO)HYDRAZINO]PHENYL] 4,5 DIHYDRO 3(2H) PYRIDAZINONE DERIVATIVE; 6 [4 [2 (1 ACETYL 1 N N BUTYLCARBAMOYLMETHYLIDENE)HYDRAZINO]PHENYL] 4,5 DIHYDRO 3(2H) PYRIDAZINONE; 6 [4 [2 (3 AMINO 5 OXO PYRAZOLIN 4 YLIDENE)HYDRAZINO]PHENYL] 4,5 DIHYDRO 3(2H) PYRIDAZINONE; 6 [4 [2 (3 METHYL 5 OXO 1 (UN)SUBSTITUTED 4 PYRAZOLINYLIDENE)HYDRAZINO]PHENYL] 4,5 DIHYDRO 3(2H) PYRIDAZINONE DERIVATIVE; 6 [4 [2 (DISUBSTITUTED METHYLIDENE)HYDRAZINO]PHENYL] 4,5 DIHYDRO 3(2H) PYRIDAZINONE DERIVATIVE; 6 [4 [2 [1 ACETYL 1 (1 N IMINOETHYL)METHYLIDENE]HYDRAZINO]PHENYL] 4,5 DIHYDRO 3(2H) PYRIDAZINONE DERIVATIVE; 6 [4 [2 [1 N METHYLCARBAMOYL 1 [1 (N METHYLIMINO)ETHYL]METHYLIDENE]HYDRAZINO]PHENYL] 4,5 DIHYDRO 3(2H) PYRIDAZINONE; 6 [4 [2 [1, 1 BIS N METHYL(ETHYL)CARBAMOYLMETHYLIDENE]HYDRAZINO]PHENYL]4,5 DIHYDRO 3(2H) PYRIDAZINONE DERIVATIVE; AMIDE; ANTIHYPERTENSIVE AGENT; DIGOXIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; CARDIOTONIC ACTIVITY; CONTROLLED STUDY; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; HYDROPHOBICITY; INOTROPISM; LD 50; MALE; MASS SPECTROMETRY; MICROANALYSIS; MOLECULAR WEIGHT; MOUSE; NONHUMAN; PHARMACOPHORE; PHYSICAL CHEMISTRY; PROTON NUCLEAR MAGNETIC RESONANCE; PURIFICATION; THROMBOCYTE AGGREGATION INHIBITION;

ANIMALS; ANTIHYPERTENSIVE AGENTS; BLOOD PLATELETS; CARDIOTONIC AGENTS; CHROMATOGRAPHY, THIN LAYER; COMPUTATIONAL BIOLOGY; FEMALE; HUMANS; INDICATORS AND REAGENTS; LETHAL DOSE 50; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MICE; MODELS, MOLECULAR; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; PYRIDAZINES; RABBITS; SPECTROPHOTOMETRY, INFRARED; STRUCTURE-ACTIVITY RELATIONSHIP; VASODILATOR AGENTS;

EID: 77949908899     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-010-2222-x     Document Type: Article

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