MR molecular imaging of thrombus: Development and application of a Gd-based novel contrast agent targeting to P-selectin

Clinical and Applied Thrombosis/Hemostasis

Volumn 16, Issue 2, 2010, Pages 177-183

  Wang, Xue Feng ^a   Jin, Pei Pei ^a   Zhou, Tong ^a   Zhao, Ya Peng ^a   Ding, Qiu Lan ^a   Wang, Deng Bin ^a   Zhao, Guang Ming ^a   Jing Dai, ^a   Wang, Hong Li ^a   Ge, Hai Liang ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Magnetic resonance imaging; Molecular; P selectin; Thrombosis

Indexed keywords

GADOLINIUM; NANOPARTICLE; PADGEM PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CIRCULATION; CONTROLLED STUDY; FEMORAL VEIN; HISTOLOGY; IN VITRO STUDY; IN VIVO STUDY; MICROTHROMBUS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN TARGETING; THROMBOCYTE AGGREGATION; THROMBUS; VASCULAR ENDOTHELIUM;

ANIMALS; ANTIBODIES, MONOCLONAL; CATTLE; CONTRAST MEDIA; DOGS; DRUG DELIVERY SYSTEMS; FEMORAL VEIN; GADOLINIUM DTPA; IMAGING, THREE-DIMENSIONAL; IMMUNOCONJUGATES; MAGNETIC RESONANCE IMAGING; MOLECULAR IMAGING; NANOPARTICLES; P-SELECTIN; SERUM ALBUMIN, BOVINE; VENOUS THROMBOSIS;

EID: 77949902413     PISSN: 10760296     EISSN: None     Source Type: Journal    
DOI: 10.1177/1076029608330470     Document Type: Article

References (26)

1. Lopez JA, Kearon C., Lee AYY. Deep venous thrombosis. Hematology Am Soc Hematol Educ Program. 2004 ; 439-456.
2. Andre P. P-selectin in haemostasis. Br J Haematol. 2004 ; 126: 298-306.
3. Polgar J., Matuskova J., Wagner DD The P-selectin, tissue factor, coagulation triad. J Thromb Haemost. 2005 ; 3: 1590-1596.
4. Stenberg PE, McEver RP, Shuman MA, Jacques YV, Bainton DF A platelet alpha-granule membrane protein (GMP-140) is expressed on the plasma membrane after activation. J Cell Biol. 1985 ; 101: 880-886.
5. Berman CL, Yeo EL, Wencel-Drake JD, Furie BC, Ginsberg MH, Furie B. A platelet alpha granule membrane protein that is associated with the plasma membrane after activation. Characterization and subcellular localization of platelet activation dependent granule-external membrane protein. J Clin Invest. 1986 ; 78: 130-137.
6. Bonfanti R., Furie BC, Furie B., Wagner DD PADGEM (GMP140) is a component of Weibel-Palade bodies of human endothelial cells. Blood. 1989 ; 73: 1109-1112.
7. McEver RP, Beckstead JH, Moore KL, Marshall-Carlson L., Bainton DF GMP-140, a platelet alpha-granule membrane protein, is also synthesized by vascular endothelial cells and is localized in Weibel-Palade bodies. J Clin Invest. 1989 ; 84: 92-99.
8. de Korte C., van der Steen A., Cepedes E., et al. Characterization of plaque components and vulnerability with intravascular ultrasound elastography. Phys Med Biol. 2000 ; 45: 1465-1475.
9. Cerqueira MD Current status of radionuclide tracer imaging of thrombi and atheroma. Semin Nucl Med. 1999 ; 29: 339-351.
10. Bogdanov A. Jr, Matuszewski L., Bremer C., Petrovsky A., Weissleder R. Oligomerization of paramagnetic substrates result in signal amplification and can be used for MR imaging of molecular targets. Mol Imaging. 2002 ; 1: 16-23.
11. Mulder WJ, Strijkers GJ, Griffioen AW, et al. A liposomal system for contrast-enhanced magnetic resonance imaging of molecular targets. Bioconjug Chem. 2004 ; 15: 799-806.
12. Yu X., Song SK, Chen J., et al. High-resolution MRI characterization of human thrombus using a novel fibrin-targeted paramagnetic nanoparticle contrast agent. Magn Reson Med. 2000 ; 44: 867-872.
13. Flacke S., Fischer S., Scott MJ, et al. Novel MRI contrast agent for molecular imaging of fibrin: implications for detecting vulnerable plaques. Circulation. 2001 ; 104: 1280-1285.
14. Moore KL, Varki A., McEver RP GMP-140 binds to a glycoprotein receptor on human neutrophils: evidence for a lectin-like interaction. J Cell Biol. 1991 ; 112: 491-499.
15. Gibson RM, Kansas GS, Tedder TF, Furie B., Furie B. C. Lectin and epidermal growth factor domains of P-selectin at physiologic density are the recognition unit for leukocyte binding. Blood. 1995 ; 85: 151-158.
16. Freedman SJ, Sanford DG, Bachovchin WW, Furie BC, Baleja JD, Furie B. Structure and function of the epidermal growth factor domain of P-selectin. Biochemistry. 1996 ; 35: 13733-13744.
17. Imam SK Molecular nuclear imaging: the radiopharmaceuticals (review). Cancer Biother Radiopharm. 2005 ; 20: 163-172.
18. Sirol M., Fuster V., Badimon JJ, et al. Chronic thrombus detection with in vivo magnetic resonance imaging and a fibrin-targeted contrast agent. Circulation. 2005 ; 112: 1594-1600.
19. Palabrica TM, Lobb R., Furie BC, et al. Leukocyte accumulation promoting fibrin deposition is mediated in vivo by P-selectin on adherent platelets. Nature. 1992 ; 359: 848-851.
20. Sullivan VV, Hawley AE, Farris DM, et al. Decrease in fibrin content of venous thrombi in selectin-deficient mice. J Surg Res. 2003 ; 109: 1-7.
21. Vandendries ER, Furie BC, Furie B. Role of P-selectin and PSGL-1 in coagulation and thrombosis. Thromb Haemost. 2004 ; 92: 459-466.
22. Kornguth SE, Turski PA, Perman WH, et al. Magnetic resonance imaging of gadolinium-labeled monoclonal antibody polymers directed at human T lymphocytes implanted in canine brain. J Neurosurg. 1987 ; 66: 898-906.
23. Ogan MD, Schmiedl U., Moseley ME, Grodd W., Paajanen H., Brasch RC Albumin labeled with Gd-DTPA. An intravascular contrast-enhancing agent for magnetic resonance blood pool imaging: preparation and characterization. Invest Radiol. 1987 ; 22: 665-671.
24. Kramer CM, Cerilli LA, Hagspiel K., DiMaria JM, Epstein FH, Kern JA Magnetic resonance imaging identifies the fibrous cap in atherosclerotic abdominal aortic aneurysm. Circulation. 2004 ; 109: 1016-1021.
25. Fuster V. Mechanisms leading to myocardial infarction: insights from studies of vascular biology. Circulation. 1994 ; 90: 2126-2146.
26. Falk E., Shah PK, Fuster V. Coronary plaque disruption. Circulation. 1995 ; 92: 657-671.