Diffusely infiltrating endometrial carcinomas with no stromal response: Report of a series, including cases with cervical and ovarian involvement and emphasis on the potential for misdiagnosis

International Journal of Surgical Pathology

Volumn 18, Issue 2, 2010, Pages 138-143

  Kalyanasundaram, K ^a   Ganesan, R ^a   Perunovic, B ^b   McCluggage, W G ^c  

^a BIRMINGHAM CHILDREN S HOSPITAL NHS FOUNDATION TRUST   (United Kingdom)

^b UNIVERSITY OF SHEFFIELD   (United Kingdom)

^c ROYAL GROUP OF HOSPITALS TRUST   (United Kingdom)

Author keywords

Cervical invasion; Endometrium; Myometrial invasion; Stromal response; Uterus

Indexed keywords

ADENOMYOMA; ADENOMYOSIS; ADULT; AGED; ARTICLE; CANCER INFILTRATION; CLEAR CELL CARCINOMA; CLINICAL ARTICLE; CONSULTATION; DIAGNOSTIC ERROR; DIFFERENTIAL DIAGNOSIS; ENDOMETRIOSIS; ENDOMETRIUM CARCINOMA; FEMALE; HUMAN; HYSTERECTOMY; MIXED ENDOMETROID CARCINOMA; MIXED TUMOR; MYOMETRIUM; OVARY CYST; PRIORITY JOURNAL; SALPINGOOOPHORECTOMY; STROMA; TUMOR LOCALIZATION; UTERINE CERVIX;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; DIAGNOSTIC ERRORS; ENDOMETRIAL NEOPLASMS; FEMALE; HUMANS; MIDDLE AGED; MYOMETRIUM; NEOPLASM INVASIVENESS; OVARIAN NEOPLASMS; STROMAL CELLS; UTERINE CERVICAL NEOPLASMS;

EID: 77949898369     PISSN: 10668969     EISSN: 19402465     Source Type: Journal    
DOI: 10.1177/1066896908329585     Document Type: Article

References (14)

1. Longacre TA, Hendrickson MR Diffusely infiltrative endometrial adenocarcinoma. An adenoma malignum pattern of myoinvasion. Am J Surg Pathol. 1999 ; 23: 69-78.
2. Landry D., Mai KT, Senterman MK, et al. Endometrioid adenocarcinoma of the uterus with a minimal deviation invasive pattern. Histopathology. 2003 ; 42: 77-82.
3. Mai KT, Perkins DG, Yazdi HM, Thomas J. Endometrioid carcinoma of the endometrium with an invasive component of minimal deviation carcinoma. Hum Pathol. 2002 ; 33: 856-858.
4. Mittal KR, Barwick KW Diffusely infiltrating adenocarcinoma of the endometrium. A subtype with poor prognosis. Am J Surg Pathol. 1988 ; 12: 754-758.
5. Tambouret R., Clement PB, Young RH Endometrial endometrioid adenocarcinoma with a deceptive pattern of spread of the uterine cervix. A manifestation of stage IIB endometrial carcinoma liable to be misinterpreted as an independent carcinoma or a benign lesion. Am J Surg Pathol. 2003 ; 27: 1080-1088.
6. Fanning J., Alvarez PM, Tsukada Y., Piver MS Prognostic significance of the extent of cervical involvement by endometrial cancer. Gynecol Oncol. 1991 ; 40: 46-47.
7. Jordan LB, Al-Nafussi A. Clinicopathological study of the pattern and significance of cervical involvement in cases of endometrial adenocarcinoma. Int J Gynecol Cancer. 2002 ; 12: 42-48.
8. Wolfson AH, Sightler SE, Markoe AM, et al. The prognostic significance of surgical staging for carcinoma of the endometrium. Gynecol Oncol. 1992 ; 45: 142-146.
9. Clement PB, Young RH Endometrioid carcinoma of the uterine corpus. Adv Anat Pathol. 2002 ; 9: 145-184.
10. McCluggage WG, Jenkins D. p16 immunoreactivity may assist in the distinction between endometrial and endocervical adenocarcinoma. Int J Gynecol Pathol. 2003 ; 22: 231-235
11. McCluggage WG, Sumathi VP, McBride HA, Patterson A. A panel of immunohistochemical stains, including carcinoembryonic antigen, vimentin and estrogen receptor aids the distinction between primary endometrial and endocervical adenocarcinomas. Int J Gynecol Pathol. 2001 ; 21 ; 11-15.
12. Castrillon DH, Lee KR, Nucci MR Distinction between endometrial and endocervical adenocarcinoma: an immunohistochemical study. Int J Gynecol Pathol. 2002 ; 21: 4-10.
13. Ordi J., Nogales FF, Palacin A., et al. Mesonephric adenocarcinoma of the uterine corpus: CD10 expression as evidence of mesonephric differentiation. Am J Surg Pathol. 2001 ; 25: 1540-1545.
14. McCluggage WG, Oliva E., Herrington CS, McBride H., Young RH CD10 and calretinin staining of endocervical glandular lesions, endocervical stroma and endometrioid adenocarcinomas of the uterine corpus: CD10 positivity is characteristic of, but not specific for, mesonephric lesions and is not specific for endometrial stroma. Histopathology. 2003 ; 43: 144-150.