Molecular modeling of the bifunctional enzyme UDP-GlcNAc 2-epimerase/ManNAc kinase and predictions of structural effects of mutations associated with HIBM and sialuria

Glycobiology

Volumn 20, Issue 3, 2009, Pages 322-337

  Kurochkina, Natalya ^a   Yardeni, Tal ^b,c   Huizing, Marjan ^b  

^a The School of Theoretical Modeling   (United States)

^b NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^c TEL AVIV UNIVERSITY   (Israel)

Author keywords

GNE; Homology model; Missense mutation; MNK; Protein structure; Sialic acid

Indexed keywords

N ACETYLMANNOSAMINE KINASE; PHOSPHOTRANSFERASE; UNCLASSIFIED DRUG; URIDINE DIPHOSPHATE N ACETYLGLUCOSAMINE 2 EPIMERASE;

ALPHA HELIX; AMINO ACID SUBSTITUTION; ARTICLE; AUTOSOMAL DISORDER; BETA SHEET; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME SUBSTRATE COMPLEX; FOUNDER EFFECT; HEREDITARY INCLUSION BODY MYOPATHY; LIGAND BINDING; MISSENSE MUTATION; MOLECULAR MODEL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN SECONDARY STRUCTURE; SIALIC ACID URINE LEVEL;

AMINO ACID SEQUENCE; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MULTIENZYME COMPLEXES; MUSCULAR DISEASES; MUTATION; N-ACETYLNEURAMINIC ACID; PROTEIN CONFORMATION; SIALIC ACID STORAGE DISEASE;

MAMMALIA; PROKARYOTA;

EID: 77949894342     PISSN: 09596658     EISSN: 14602423     Source Type: Journal    
DOI: 10.1093/glycob/cwp176     Document Type: Article

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