VCAM-1 blockade delays disease onset, reduces disease severity and inflammatory cells in an atopic dermatitis model

Immunology and Cell Biology

Volumn 88, Issue 3, 2010, Pages 334-342

  Chen, Lin ^a   Lin, Shao Xia ^a   Amin, Sanober ^a   Overbergh, Lut ^b   Maggiolino, Giacomo ^a   Chan, Lawrence S ^a,c  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b UNIVERSITY OF LEUVEN   (Belgium)

^c JESSE BROWN VA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA4 INTEGRIN; CYTOKERATIN 14; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 4; L SELECTIN; MESSENGER RNA; NEUTRALIZING ANTIBODY; P SELECTIN GLYCOPROTEIN LIGAND 1; PADGEM PROTEIN; VASCULAR CELL ADHESION MOLECULE 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN EXPRESSION; ARTICLE; ATOPIC DERMATITIS; CD3+ T LYMPHOCYTE; CELL ADHESION; CELL INFILTRATION; CONTROLLED STUDY; DERMIS; DISEASE COURSE; DISEASE SEVERITY; DNA CROSS LINKING; EOSINOPHIL; GENE DELETION; GENE FREQUENCY; HYPOTHESIS; INFLAMMATORY CELL; KNOCKOUT MOUSE; MAST CELL; MOUSE; NONHUMAN; ONSET AGE; SKIN BLOOD VESSEL; SKIN DEFECT; TRANSGENIC MOUSE; TREATMENT OUTCOME;

ANIMALS; ANTIBODIES, NEUTRALIZING; CELL MOVEMENT; DERMATITIS, ATOPIC; DISEASE MODELS, ANIMAL; E-SELECTIN; EOSINOPHILS; HUMANS; INFLAMMATION; KERATIN-14; L-SELECTIN; MAST CELLS; MEMBRANE GLYCOPROTEINS; MICE; MICE, KNOCKOUT; NK CELL LECTIN-LIKE RECEPTOR SUBFAMILY D; P-SELECTIN; SEVERITY OF ILLNESS INDEX; SKIN; T-LYMPHOCYTES; VASCULAR CELL ADHESION MOLECULE-1;

MUS; MUS MUSCULUS;

EID: 77949875663     PISSN: 08189641     EISSN: 14401711     Source Type: Journal    
DOI: 10.1038/icb.2009.107     Document Type: Article

References (35)

1. Leung DY, Boguniewicz M, Howell MD, Nomura I, Hamid QA. New insights into atopic dermatitis. J Clin Invest 2004; 113: 651-657.
2. Leung DY, Bieber T. Atopic dermatitis. Lancet 2003; 361: 151-160. (Pubitemid 36092023)
3. Cooper KD. Atopic dermatitis: recent trends in pathogenesis and therapy. J Invest Dermatol 1994; 102: 128-137.
4. Reinhold U, Kukel S, Goeden B, Neumann U, Kreysel HW. Functional characterization of skin-infiltrating lymphocytes in atopic dermatitis. Clin Exp Immunol 1991; 86: 444-448.
5. Steinhoff M, Steinhoff A, Homey B, Luger TA, Schneider SW. Role of vasculature in atopic dermatitis. J Allergy Clin Immunol 2006; 118: 190-197.
6. Schon MP, Zollner TM, Boehncke WH. The molecular basis of lymphocyte recruitment to the skin: clues for pathogenesis and selective therapies of inflammatory disorders. J Invest Dermatol 2003; 121: 951-962.
7. Chan LS, Robinson N, Xu L. Expression of interleukin-4 in the epidermis of transgenic mice results in a pruritic inflammatory skin disease: an experimental animal model to study atopic dermatitis. J Invest Dermatol 2001; 117: 977-983.
8. Hanifin JM, Rajka G. Diagnostic features of atopic dermatitis. Acta Derm Venereol 1980; 92: 44-47.
9. Chen L, Martinez O, Overbergh L, Mathieu C, Prabhakar BS, Chan LS. Early upregulation of Th2 cytokines and late surge of Th1 cytokines in an atopic dermatitis model. Clin Exp Immunol 2004; 138: 375-387.
10. Chen L, Martinez O, Venkataramani P, Lin SX, Prabhakar BS, Chan LS. Correlation of disease evolution with progressive inflammatory cell activation and migration in the IL-4 transgenic mouse model of atopic dermatitis. Clin Exp Immunol 2005; 139: 189-201.
11. Chen L, Lin SX, Agha-Majzoub R, Overbergh L, Mathieu C, Chan LS. CCL27 is a critical factor for the development of atopic dermatitis in the keratin-14 IL-4 transgenic mouse model. Int Immunol 2006; 18: 1233-1242.
12. Jung K, Linse F, Heller R, Moths C, Goebel R, Neumann C. Adhesion molecules in atopic dermatitis: VCAM-1 and ICAM-1 expression is increased in healthy-appearing skin. Allergy 1996; 51: 452-460.
13. Boone M, Lespagnard L, Renard N, Song M, Rihoux JP. Adhesion molecule profiles in atopic dermatitis vs allergic contact dermatitis: pharmacological modulation by cetirizine. J Eur Acad Dermatol Venereol 2000; 14: 263-266.
14. Lugovic L, Cupic H, Lipozencic J, Jakic-Razumovic J. The role of adhesion molecules in atopic dermatitis. Acta Dermatovenerol Croat 2006; 14: 2-7.
15. Sigurdsson V, de Vries IJ, Toonstra J, Bihari IC, Thepen T, Bruijnzeel-Koomen CA et al. Expression of VCAM-1, ICAM-1, E-selectin, and P-selectin on endothelium in situ in patients with erythroderma, mycosis fungoides and atopic dermatitis. J Cutan Pathol 2000; 27: 436-440.
16. Koide M, Tokura Y, Furukawa F, Takigawa M. Soluble intercellular adhesion molecule-1 (sICAM-1) in atopic dermatitis. J Dermatol Sci 1994; 8: 151-156.
17. Koide M, Furukawa F, Tokura Y, Shirahama S, Takigawa M. Evaluation of soluble cell adhesion molecules in atopic dermatitis. J Dermatol 1997; 24: 88-93.
18. Hirai S, Kageshita T, Kimura T, Tsujisaki M, Okajima K, Imai K et al. Soluble intercellular adhesion molecule-1 and soluble E-selectin levels in patients with atopic dermatitis. Br J Dermatol 1996; 134: 657-661.
19. Kojima T, Ono A, Aoki T, Kameda-Hayashi N, Kobayashi Y. Circulating ICAM-1 levels in children with atopic dermatitis. Ann Allergy 1994; 73: 351-355.
20. Wuthrich B, Joller-Jemelka H, Kagi MK. Levels of soluble ICAM-1 in atopic dermatitis A new marker for monitoring the clinical activity? Allergy 1995; 50: 88-89.
21. Yamashita N, Kaneko S, Kouro O, Furue M, Yamamoto S, Sakane T. Soluble E-selectin as a marker of disease activity in atopic dermatitis. J Allergy Clin Immunol 1997; 99: 410-416.
22. Wolkerstorfer A, Laan MP, Savelkoul HF, Neijens HJ, Mulder PG, Oudesluys-Murphy AM et al. Soluble E-selectin, other markers of inflammation and disease severity in children with atopic dermatitis. Br J Dermatol 1998; 138: 431-435.
23. Hao JS, Shan BE. Immune enhancement and anti-tumour activity of IL-23. Cancer Immunol Immunother 2006; 55: 1426-1431.
24. Silber A, Newman W, Sasseville VG, Pauley D, Beall D, Walsh DG et al. Recruitment of lymphocytes during cutaneous delayed hypersensitivity in nonhuman primates is dependent on E-selectin and vascular cell adhesion molecule 1. J Clin Invest 1994; 93: 1554-1563.
25. Chisholm PL, Williams CA, Lobb RR. Monoclonal antibodies to the integrin alpha-4 subunit inhibit the murine contact hypersensitivity response. Eur J Immunol 1993; 23: 682-688.
26. Nakajima H, Sano H, Nishimura T, Yoshida S, Iwamoto I. Role of vascular cell adhesion molecule 1/very late activation antigen 4 and intercellular adhesion molecule 1/ lymphocyte function-associated antigen 1 interactions in antigen-induced eosinophil and T cell recruitment into the tissue. J Exp Med 1994; 179: 1145-1154.
27. Baron JL, Reich EP, Visintin I, Janeway Jr CA. The pathogenesis of adoptive murine autoimmune diabetes requires an interaction between alpha 4-integrins and vascular cell adhesion molecule-1. J Clin Invest 1994; 93: 1700-1708.
28. Hemler ME. VLA proteins in the integrin family: structures, functions, and their role on leukocytes. Annu Rev Immunol 1990; 8: 365-400.
29. Chen L, Lin SX, Overbergh L, Mathieu C, Chan LS. The disease progression in the keratin 14 IL-4-transgenic mouse model of atopic dermatitis parallels the upregulations of B cell activation molecules, proliferation, and surface and serum IgE. Clin Exp Immunol 2005; 142: 21-30.
30. Kootstra CJ, Van Der Giezen DM, Van Krieken JH, De Heer E, Bruijn JA. Effective treatment of experimental lupus nephritis by combined administration of anti-CD11a and anti-CD54 antibodies. Clin Exp Immunol 1997; 108: 324-332.
31. Giulietti A, Overbergh L, Valckx D, Decallonne B, Bouillon R, Mathieu C. An overview of real-time quantitative PCR: applications to quantify cytokine gene expression. Methods 2001; 25: 386-401.
32. Maatta J, Majuri ML, Luukkonen R, Lauerma A, Husgafvel-Pursiainen K, Alenius H et al. Characterization of oak and birch dust-induced expression of cytokines and chemokines in mouse macrophage RAW 264 7 cells. Toxicology 2005; 215: 25-36.
33. Broberg EK, Setala N, Eralinna JP, Salmi AA, Roytta M, Hukkanen V. Herpes simplex virus type 1 infection induces upregulation of interleukin-23 (p19) mRNA expression in trigeminal ganglia of BALB/c mice. J Interferon Cytokine Res 2002; 22: 641-651.
34. Jean-Baptiste S, OToole EA, Chen M, Guitart J, Paller A, Chan LS. Expression of eotaxin, an eosinophil-selective chemokine, parallels eosinophil accumulation in the vesiculobullous stage of incontinentia pigmenti. Clin Exp Immunol 2002; 127: 470-478.
35. Elbe-Burger A, Egyed A, Olt S, Klubal R, Mann U, Rappersberger K et al. Overexpression of IL-4 alters the homeostasis in the skin. J Invest Dermatol 2002; 118: 767-778.