Diclofenac-induced stimulation of SMCT1 (SLC5A8) in a heterologous expression system: A RPE specific phenomenon

Biochemical and Biophysical Research Communications

Volumn 394, Issue 1, 2010, Pages 75-80

  Ananth, Sudha ^a   Zhuang, Lina ^a   Gopal, Elangovan ^a   Itagaki, Shiro ^a   Ellappan, Babu ^a   Smith, Sylvia B ^a   Ganapathy, Vadivel ^a   Martin, Pamela ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

Diclofenac; NSAIDs; RPE; SLC5A8; SMCT1

Indexed keywords

3 HYDROXYBUTYRIC ACID; COMPLEMENTARY DNA; DICLOFENAC; LACTIC ACID; MONOCARBOXYLATE TRANSPORTER; NICOTINIC ACID; PYRUVIC ACID; SODIUM COUPLED MONOCARBOXYLATE TRANSPORTER 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL SPECIFICITY; CELL STRAIN MCF 7; CELL TYPE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG SPECIFICITY; DRUG TARGETING; ENZYME ACTIVITY; ENZYME SUBSTRATE; HETEROLOGOUS EXPRESSION; HUMAN; HUMAN CELL; NONHUMAN; OOCYTE; PIGMENT EPITHELIUM; PRIORITY JOURNAL; PROTEIN TRANSPORT; XENOPUS LAEVIS;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CATION TRANSPORT PROTEINS; CELL LINE; CELL LINE, TUMOR; DICLOFENAC; HUMANS; OOCYTES; RETINAL PIGMENT EPITHELIUM; XENOPUS LAEVIS;

MAMMALIA; XENOPUS LAEVIS;

EID: 77949874932     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2010.02.109     Document Type: Article

References (25)

1. +-coupled transporter for short-chain fatty acids. J. Biol. Chem. 279 (2004) 13293-13296
2. +-coupled transport of lactate. J. Biol. Chem. 279 (2004) 44522-44532
3. +/glucose cotransporter gene family. Biochem. J. 388 (2005) 309-316
4. +-coupled transporter for active uptake of l-lactate and ketone bodies in the brain. J. Neurochem. 98 (2006) 279-288
5. Gopal E., Miyauchi S., Martin P.M., et al. Transport of nicotinate and structurally related compounds by human SMCT1 (SLC5A8) and its relevance to drug transport in the mammalian intestinal tract. Pharm. Res. 24 (2007) 575-584
6. Ganapathy V., Gopal E., Miyauchi S., and Prasad P.D. Biological functions of SLC5A8, a candidate tumor suppressor. Biochem. Soc. Trans. 33 (2005) 237-240
7. Gupta N., Martin P.M., Prasad P.D., and Ganapathy V. SLC5A8 (SMCT1)-mediated transport of butyrate forms the basis for the tumor-suppressive function of the transporter. Life Sci. 78 (2006) 2419-2425
8. Ganapathy V., Thangaraju M., Gopal E., Itagaki S., Miyauchi S., and Prasad P.D. Sodium-coupled monocarboxylate transporters in normal tissues and in cancer. AAPS J. 10 (2008) 193-199
9. Ganapathy V., Thangaraju M., and Prasad P.D. Nutrient transporters in cancer: relevance to Warburg hypothesis and beyond. Pharmacol. Ther. 121 (2009) 29-40
10. Martin P.M., Dun Y., Mysona B.A., et al. Expression of the sodium-coupled monocarboxylate transporters SMCT1 (Slc5a8) and SMCT2 (Slc5a12) in retina. Invest. Ophthalmol. Vis. Sci. 48 (2007) 3356-3363
11. Thangaraju M., Ananth S., Martin P.M., et al. C/ebp null mouse as a model for the double-knockout of Slc5a8 and Slc5a12 in kidney. J. Biol. Chem. 281 (2006) 26769-26773
12. Frank H., Groger N., Diener M., Becker C., Braun T., and Boettger T. Lactaturia and loss of sodium-dependent lactate uptake in the colon of SLC5A8-deficient mice. J. Biol. Chem. 283 (2008) 24729-24737
13. Itagaki S., Gopal E., Zhuang L., et al. Interaction of ibuprofen and other structurally related NSAIDs with the sodium-coupled monocarboxylate transporter SMCT1 (SLC5A8). Pharm. Res. 23 (2006) 1209-1216
14. Kern T.S., Miller C.M., Du Y., et al. Topical administration of nepafenac inhibits diabeties-induced retinal microvascular disease and underlying abnormalities of retinal metabolism and physiology. Diabetes 56 (2006) 373-379
15. Joussen A.M., Poulaki V., Mitsiades N., et al. Nonsteroidal anti-inflammatory drugs prevent early diabetic retinopathy via TNF-suppression. FASEB J. 16 (2002) 438-440
16. Almeida D.R., Johnson D., Hollands H., et al. Effect of prophylactic nonsteroidal anti-inflammatory drugs on cystoid macular edema assessed using optical coherence tomography quantification of total macular volume after cataract surgery. J. Cataract. Refract. Surg. 34 (2008) 64-69
17. Wu X., George R.L., Huang W., et al. Structural and functional characteristics and tissue distribution pattern of rat OCTN1, an organic cation transporter, cloned from placenta. Biochim. Biophys. Acta 1466 (2000) 315-327
18. Seth P., Wu X., Huang W., Leibach F.H., and Ganapathy V. Mutations in OCTN2, an organic cation/carnitine transporter, with differential effects on the organic cation transport function and the carnitine transport function. J. Biol. Chem. 274 (1999) 33388-33392
19. Wu X., Huang W., Ganapathy M.E., et al. Structure, function and regional distribution of the organic cation transporter OCT3 in the kidney. Am. J. Physiol. 279 (2000) F449-F458
20. Wang H., Huang W., Sugawara M., et al. Cloning and functional expression of ATA1, a subtype of amino acid transporter A, from human placenta. Biochem. Biophys. Res. Commun. 273 (2000) 1175-1179
21. Hatanaka T., Huang W., Wang H., et al. Primary structure, functional characteristics and tissue expression pattern of human ATA2, a subtype of amino acid transport system A. Biochim. Biophys. Acta 1467 (2000) 1-6
22. Ramamoorthy S., Leibach F.H., Mahesh V.B., et al. Functional characterization and chromosomal localization of a cloned taurine transporter from human placenta. Biochem. J. 300 (1994) 893-900
23. Eriksen J.L., Sagi S.A., Smith T.E., et al. NSAIDs and enantiomers of flurbiprofen target-secretase and lower A42 in vivo. J. Clin. Invest. 112 (2003) 440-449
24. Thangaraju M., Gopal E., Martin P.M., et al. SLC5A8 triggers tumor cell apoptosis through pyruvate-dependent inhibition of histone deacetylases. Cancer Res. 66 (2006) 11560-11564
25. Thangaraju M., Carswell K.N., Prasad P.D., and Ganapathy V. Colon cancer cells maintain low levels of pyruvate to avoid cell death caused by inhibition of HDAC1/HDAC3. Biochem. J. 417 (2009) 379-389