Anti-inflammatory bioactivities of honokiol through inhibition of protein kinase C, mitogen-activated protein kinase, and the NF-κB pathway to reduce LPS-lnduced TNFa and no expression

Journal of Agricultural and Food Chemistry

Volumn 58, Issue 6, 2010, Pages 3472-3478

  Chao, Louis Kuoping ^a   Liao, Pei Chun ^b   Ho, Chen Lung ^c   Wang, Eugene I Chen ^c   Chuang, Chao Chin ^d   Chiu, Huan Wen ^d   Hung, Lang Bang ^c   Hua, Kuo Feng ^a,e  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b NATIONAL ILAN UNIVERSITY   (Taiwan)

^c TAIWAN FORESTRY RESEARCH INSTITUTE   (Taiwan)

^d NATIONAL TAIWAN OCEAN UNIVERSITY   (Taiwan)

^e Yonghe Elementary School   (Taiwan)

Author keywords

Cytokines; Honokiol; LPS; Signaling

Indexed keywords

ANTIINFLAMMATORY AGENT; BIPHENYL DERIVATIVE; HONOKIOL; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIGNAN; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; NITRIC OXIDE; PROTEIN KINASE C; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL; ARTICLE; CELL CULTURE; CELL LINE; DOWN REGULATION; DRUG EFFECT; GENETICS; HUMAN; IMMUNOLOGY; MACROPHAGE; METABOLISM; MOUSE; SIGNAL TRANSDUCTION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; BIPHENYL COMPOUNDS; CELL LINE; CELLS, CULTURED; DOWN-REGULATION; HUMANS; LIGNANS; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; NITRIC OXIDE; PROTEIN KINASE C; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

MAGNOLIA OFFICINALIS; MAGNOLIACEAE; MURINAE;

EID: 77949872092     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/jf904207m     Document Type: Article

References (30)

1. Medzhitov, R.; Janeway, C. A. Innate immunity: the virtues of a nonclonal system of recognition. Cell 1997, 91, 295-298.
2. Takeda, K.; Kaisho, T.; Akira, S. Toll-like receptors. Annu. Rev. Immunol. 2003, 21, 335-376.
3. Verstrepen, L.; Bekaert, T.; Chau, T. L.; Tavernier, J.; Chariot, A.; Beyaert, R. TLR-4, IL-1R and TNF-R signaling to NF-kappaB: variations on a common theme. Cell Mol. Life Sci. 2008, 65, 2964-2978.
4. DasGupta, S.; Murumkar, P. R.; Giridhar, R.; Yadav, M. R. Current perspective of TACE inhibitors: a review. Bioore. Med. Chem. 2009, 17, 444-459.
5. Hsu, H. Y.; Wen, M. H. Lipopolysaccharide-mediated reactive oxygen species and signal transduction in the regulation of interleukin-1 gene expression. J. Biol. Chem. 2002, 277, 22131-22139.
6. Giroux, M.; Descoteaux, A. Cyclooxygenase-2 expression in macrophages: modulation by protein kinase C-alpha. J. Immunol. 2000, 165, 3985-3991.
7. Hsu, H. Y.; Hua, K. F.; Wu, W. C.; Hsu, J.; Weng, S. T.; Lin, T. L.; Liu, C. Y.; Hseu, R. S.; Huang, C. T. Reishi immuno-modulation protein induces interleukin-2 expression via protein kinase-dependent signaling pathways within human T cells. J. Cell Phvsiol. 2008, 215, 15-26.
8. Baeuerle, P. A.; Baltimore, D. NF-kappa B: ten years after. Cell 1996, 57, 13-20.
9. Ishitsuka, K.; Hideshima, T.; Hamasaki, M.; Raje, N.; Kumar, S.; Hideshima, H.; Shiraishi, N.; Yasui, H.; Roccaro, A. M.; Richardson, P.; Podar, K.; Le, Gouill S.; Chauhan, D.; Tamura, K.; Arbiser, J.; Anderson, K. C. Honokiol overcomes conventional drug resistance in human multiple myeloma by induction of caspase-dependent and -independent apoptosis. Blood 2005, 106, 1794-1800.
10. Bai, X.; Cerimele, F.; Ushio-Fukai, M.; Waqas, M.; Campbell, P. M.; Govindarajan, B.; Der, C. J.; Battle, T.; Frank, D. A.; Ye, K.; Murad, E.; Dubiel, W.; Soff, G.; Arbiser, J. L. Honokiol, a small molecular weight natural product, inhibits angiogenesis in vitro and tumor growth in vivo. J. Biol. Chem. 2003, 278, 35501-35507.
11. Lee, J.; Jung, E.; Park, J.; Jung, K.; Lee, S.; Hong, S.; Park, J.; Park, E.; Kim, J.; Park, S.; Park, D. Anti-inflammatory effects of magnolol and Honokiol are mediated through inhibition of the downstream pathway of MEKK-1 in NF-kappaB activation signaling. Planta Med. 2005, 71, 338-343.
12. Liou, K. T.; Shen, Y. C.; Chen, C. F.; Tsao, C. M.; Tsai, S. K. The anti-inflammatory effect of Honokiol on neutrophils: mechanisms in the inhibition of reactive oxygen species production. Eur. J. Pharmacol. 2003, 475, 19-27.
13. Kim, B. H; Cho, J. Y. Anti-inflammatory effect of honokiol is mediated by PI3K/Akt pathway suppression. Acta Pharmacol. Sin. 2008, 29, 113-122.
14. Chao, L. K.; Hua, K. F.; Hsu, H. Y.; Cheng, S. S.; Lin, I. F.; Chen, C. J.; Chen, S. T.; Chang, S. T. Cinnamaldehyde inhibits pro-inflammatory cytokines secretion from monocytes/macrophages through suppression of intracellular signaling. Food Chem. Toxicol. 2008, 46, 220-231.
15. Black, R. A.; Rauch, C. T.; Kozlosky, C. J.; Peschon, J. J.; Slack, J. L.; Wolfson, M. F.; Castner, B. J.; Stocking, K. L.; Reddy, P.; Srinivasan, S.; Nelson, N.; Boiani, N.; Schooley, K. A.; Gerhart, M.; Davis, R.; Fitzner, J. N.; Johnson, R. S.; Paxton, R. J.; March, C. J.; Cerretti, D. P. A metalloproteinase disintegrin that releases tumournecrosis factor-alpha from cells. Nature 1997, 385, 729-733.
16. Jones, E.; Adcock, I. M.; Ahmed, B. Y.; Punchard, N. A. Modulation of LPS stimulated NF-kappaB mediated Nitric Oxide production by PKCepsilon and JAK2 in RAW macrophages. J. Inflammation (London) 2007, 4, 23-31.
17. Wolf, I.; O'Kelly, J.; Wakimoto, N.; Nguyen, A.; Amblard, F.; Karlan, B. Y.; Arbiser, J. L.; Koeffler, H. P. Honokiol, a natural biphenyl, inhibits in vitro and in vivo growth of breast cancer through induction of apoptosis and cell cycle arrest, Int. J. Oncol. 2007, 30, 1529-1537.
18. Sheu, M. L.; Liu, S. H.; Lan, K. H. Honokiol induces calpainmediated glucose-regulated protein-94 cleavage and apoptosis in human gastric cancer cells and reduces tumor growth. FMS QNE 2007, 10, e1096.
19. Li, L.; Han, W.; Gu, Y.; Qiu, S.; Lu, Q.; Jin, J.; Luo, J.; Hu, X. Honokiol induces a necrotic cell death through the mitochondrial permeability transition pore. Cancer Res. 2007, 67, 4894-4903.
20. Ou, H. C.; Chou, F. P.; Lin, T. M.; Yang, C. H.; Sheu, W. H. Protective effects of honokiol against oxidized LDL-induced cytotoxicity and adhesion molecule expression in endothelial cells. Chem. Biol. Interact. 2006, 161, 1-13.
21. Munroe, M. E.; Arbiser, J. L.; Bishop, G. A. Honokiol, a natural plant product, inhibits inflammatory signals and alleviates inflammatory arthritis. J. Immunol. 2007, 179, 753-763.
22. Park, J.; Lee, J.; Jung, E.; Park, Y.; Kim, K.; Park, B.; Jung, K.; Park, E.; Kim, J.; Park, D. In vitro antibacterial and anti-inflammatory effects of honokiol and magnolol against Propionibacterium sp. Eur. J. Pharnacol. 2004, 496, 189-195.
23. Su, S. C.; Hua, K. F.; Lee, H.; Chao, L. K.; Tan, S. K.; Lee, H.; Yang, S. F.; Hsu, H. Y. LTA and LPS mediated activation of protein kinases in the regulation of inflammatory cytokines expression in macrophages. Clin. Chim. Acta 2006, 374, 106-115.
24. Baumgart, D. C.; Sandborn, W. J. Inflammatory bowel disease: clinical aspects and established and evolving therapies. Lancet 2007, 369, 1641-1657.
25. 2-terminal kinase phosphorylation and protects against glycochenodeoxycholic acid-induced apoptosis in primary cultured rat hepatocytes. Planta Med. 2006, 72, 661-664.
26. Zhai, H.; Nakade, K.; Oda, M.; Mitsumoto, Y.; Akagi, M.; Sakurai, J.; Fukuyama, Y. Honokiol-induced neurite outgrowth promotion depends on activation of extracellular signal-regulated kinases (ERK1/2). Eur. J. Pharmacol. 2005, 516, 112-117.
27. Lee, B.; Kim, C. H.; Moon, S. K. Honokiol causes the p21WAFImediated G(1)-phase arrest of the cell cycle through inducing p38 mitogen activated protein kinase in vascular smooth muscle cells. FEBS Lett. 2006, 580, 5177-5184.
28. Müller, J. M.; Ziegler-Heitbrock, H. W.; Baeuerle, P. A. Nuclear factor kappaB, a mediator of lipopolysaccharide effects. Immunobiology 1993, 187, 233-256.
29. Sheu, M. L.; Chiang, C. K.; Tsai, K. S.; Ho, F. M.; Weng, T. I.; Wu, H. Y.; Liu, S. H. Inhibition of NADPH oxidase-related oxidative stress-triggered signaling by honokiol suppresses high glucoseinduced human endothelial cell apoptosis. Free Radical Biol. Med. 2008, 44, 2043-2050.
30. Ahn, K. S.; Sethi, G.; Shishodia, S.; Sung, B.; Arbiser, J. L.; Aggarwal, B. B. Honokiol potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through modulation of nuclear factor-kappaB activation pathway. Mol. Cancer Res. 2006, 4, 621-633.