Blueberry treatment antagonizes C-2 ceramide-Lnduced stress signaling in muscarinic receptor-transfected cos-7 cells

Journal of Agricultural and Food Chemistry

Volumn 58, Issue 6, 2010, Pages 3380-3392

  Joseph, James A ^a   Bielinski, Donna F ^a   Fisher, Derek R ^a  

^a TUFTS UNIVERSITY   (United States)

Author keywords

Aging; Blueberry polyphenols; Ceramide; Muscarinic receptors; Oxidative stress

Indexed keywords

CERAMIDE; MUSCARINIC RECEPTOR; PLANT EXTRACT;

ANIMAL; ARTICLE; BLUEBERRY; CELL STRAIN COS1; CERCOPITHECUS; CHEMISTRY; DRUG EFFECT; FRUIT; METABOLISM; OXIDATIVE STRESS; SIGNAL TRANSDUCTION;

ANIMALS; BLUEBERRY PLANT; CERAMIDES; CERCOPITHECUS AETHIOPS; COS CELLS; FRUIT; OXIDATIVE STRESS; PLANT EXTRACTS; RECEPTORS, MUSCARINIC; SIGNAL TRANSDUCTION;

VACCINIUM;

EID: 77949836396     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/jf9039155     Document Type: Article

References (61)

1. Hannun, Y. A. Functions of ceramide in coordinating cellular responses to stress. Science 1996, 274 (5294), 1855-1859
2. Kolesnick, R.; Golde, D. W. The sphingomyelin pathway in tumor necrosis factor and interleukin-1 signaling. Cell 1994, 77 (3), 325-328
3. Mathias, S.; Pena, L. A.; Kolesnick, R. N. Signal transduction of stress via ceramide. Biochem. J. 1998, 335 (Pt 3), 465-480
4. Spence, M. W.; Burgess, J. K. Acid and neutral sphingomyelinases of rat brain. Activity in developing brain and regional distribution in adult brain. J. Neurochem. 1978, 30 (4), 917-919
5. Lambeng, N.; Michel, P. P.; Brugg, B.; Agid, Y.; Ruberg, M. Mechanisms of apoptosis in PC12 cells irreversibly differentiated with nerve growth factor and cyclic AMP. Brain Res. 1999, 821 (1), 60-68
6. Yang, J.; Liu, X.; Bhalla, K.; Kim, C. N.; Ibrado, A. M.; Cai, J.; Peng, T. I.; Jones, D. P.; Wang, X. Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked. Science 1997, 275(5303), 1129-1132
7. Nakane, M.; Kubota, M.; Nakagomi, T.; Tamura, A.; Hisaki, H.; Shimasaki, H.; Ueta, N. Lethal forebrain ischemia stimulates sphingomyelin hydrolysis and ceramide generation in the gerbil hippocampus. Neurosci. Lett. 2000, 296 (2-3), 89-92.
8. Mouton, R. E.; Venable, M. E. Ceramide induces expression of the senescence histochemical marker, beta-galactosidase, in human fibroblasts. Mech. Ageine Dev. 2000, 113 (3), 169-181
9. Venable, M. E.; Blobe, G. C.; Obeid, L. M. Identification of a defect in the phospholipase D/diacylglycerol pathway in cellular senescence. J. Biol. Chem. 1994, 269 (42), 26040-26044
10. Venable, M. E.; Lee, J. Y.; Smyth, M. J.; Bielawska, A.; Obeid, L. M. Role of ceramide in cellular senescence. J. Biol.Chem. 1995, 270 (51), 30701-30708
11. Obeid, L. M.; Hannun, Y. A. Ceramide, stress, and a "LAG" in aging. Sci. Aging Knowl. Environ. 2003, 2003 (39), PE27.
12. Hannun, Y. A.; Obeid, L. M. The Ceramide-centric universe of lipidmediated cell regulation: stress encounters of the lipid kind. J. Biol. Chem. 2002, 277 (29), 25847-25850
13. Denisova, N. A.; Strain, J. G.; Joseph, J. A. Oxidant injury in PC12 cells-a possible model of calcium "dysregulation" in aging: II. Interactions with membrane lipids. J. Neurochem. 1997, 69 (3), 1259-1266
14. Denisova, N. A.; Fisher, D.; Provost, M.; Joseph, J. A. The role of glutathione, membrane sphingomyelin, and its metabolites in oxidative stress-induced calcium "dysregulation" in PC12 cells. Free Radical Biol. Med. 1999, 27 (11-12), 1292-1301
15. Cutler, R. G.; Kelly, J.; Storie, K.; Pedersen, W. A.; Tammara, A.; Hatanpaa, K.; Troncoso, J. C.; Mattson, M. P. Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease. Proc. Natl. Acad. Sci. U.S.A. 2004, 101 (7), 2070-2075
16. Ayasolla, K.; Khan, M.; Singh, A. K.; Singh, I. Inflammatory mediator and beta-amyloid (25-35)-induced ceramide generation and iNOS expression are inhibited by vitamin E. Free Radical Biol. Med. 2004, 37 (3), 325-338
17. Cotrina, M. L.; Nedergaard, M. Astrocytes in the aging brain. J. Neurosci. Res. 2002, 67 (1), 1-10.
18. Puglielli, L.; Ellis, B. C.; Saunders, A. J.; Kovacs, D. M. Ceramide stabilizes beta-site amyloid precursor protein-cleaving enzyme 1 and promotes amyloid beta-peptide biogenesis. J. Biol. Chem. 2003, 278 (22), 19777-19783
19. Colombaioni, L.; Garcia-Gil, M. Sphingolipid metabolites in neural signalling and function. Brain Res. Brain Res. Rev. 2004, 46 (3), 328-355
20. Patil, S.; Melrose, J.; Chan, C. Involvement of astroglial, ceramide in palmitic acid-induced Alzheimer-like changes in primary neurons. Eur. J. Neurosci. 2007, 26 (8), 2131-2141
21. Tamboli, I. Y.; Prager, K.; Barth, E.; Heneka, M.; Sandhoff, K.; Walter, J. Inhibition of glycosphingolipid biosynthesis reduces secretion of the beta-amyloid precursor protein and amyloid betapeptide. J. Biol. Chem. 2005, 280 (30), 28110-28117
22. Xie, C. W. Calcium-regulated signaling pathways: role in amyloid beta-induced synaptic dysfunction. Neuromol. Med. 2004, 6 (1), 53-64.
23. Joseph, J. A.; Shukitt-Hale, B.; Denisova, N. A.; Bielinski, D.; Martin, A.; McEwen, J. J.; Bickford, P. C. Reversals of age-related declines in neuronal signal transduction, cognitive, and motor behavioral deficits with blueberry, spinach, or strawberry dietary supplementation. J. Neurosci. 1999, 19 (18), 8114-8121
24. 2+ regulation and gene expression in normal brain aging. Trends Neurosci. 2004, 27 (10), 614-620
25. France-Lanord, V.; Brugg, B.; Michel, P. P.; Agid, Y.; Ruberg, M. Mitochondrial free radical signal in ceramide-dependent apoptosis: a putative mechanism for neuronal death in Parkinson's disease. J. Neurochem. 1997, 69 (4), 1612-1621
26. Hunot, S.; Brugg, B.; Ricard, D.; Michel, P. P.; Muriel, M. P.; Ruberg, M.; Faucheux, B. A.; Agid, Y.; Hirsch, E. C. Nuclear translocation of NF-kappaB is increased in dopaminergic neurons of patients with parkinson disease. Proc. Natl. Acad. Sci. U.S.A. 1997, 94 (14), 7531-7536
27. Meydani, S. N.; Wu, D. Age-associated inflammatory changes: role of nutritional intervention. Nutr. Rev. 2007, 65 (12 Pt 2), S213-6.
28. Jana, A.; Hogan, E. L.; Pahan, K. Ceramide and neurodegeneration: susceptibility of neurons and oligodendrocytes to cell damage and death. J. Neurol. Sci. 2009, 278 (1-2), 5-15.
29. Joseph, J. A.; Fisher, D. R.; Strain, J. Muscarinic receptor subtype determines vulnerability to oxidative stress in COS-7 cells. Free Radical Biol. Med. 2002, 32 (2), 153-161
30. Roth, G. S.; Joseph, J. A.; Mason, R. P. Membrane alterations as causes of impaired signal transduction in Alzheimer's disease and aging. Trends Neurosci. 1995, 18 (5), 203-206
31. Fowler, C. J.; Cowburn, R. F.; Joseph, J. A. Alzheimer's, ageing and amyloid: an absurd allegory? Gerontology 1997, 43 (1-2), 132-142
32. Joseph, J. A.; Fisher, D. R. Muscarinic receptor subtype determines vulnerability to amyloid beta toxicity in transfected cos-7 cells. J. Alzheimer's Dis. 2003, 5 (3), 197-208.
33. Joseph, J. A.; Neuman, A.; Bielinski, D. F.; Fisher, D. R. Blueberry antagonism of C-2 ceramide disruption of Ca2+ responses and recovery in MAChR-transfected COS-7 cell. J. Alzheimer's Dis. 2008, 15 (3), 429-441
34. Joseph, J. A.; Fisher, D. R.; Carey, A. N.; Neuman, A.; Bielinski, D. F. Dopamine-induced stress signaling in COS-7 cells transfected with selectively vulnerable muscarinic receptor subtypes is partially mediated via the i3 loop and antagonized by blueberry extract. J. Alzheimer's Dis. 2006, 10 (4), 423-437
35. Joseph, J. A.; Carey, A.; Brewer, G. J.; Lau, F. C.; Fisher, D. R. Dopamine and abeta-induced stress signaling and decrements in Ca2+ buffering in primary neonatal hippocampal cells are antagonized by blueberry extract. J. Alzheimer's Dis. 2007, 11 (4), 433-446
36. Shelke, R. R.; Leeuwenburgh, C. Lifelong caloric restriction increases expression of apoptosis repressor with a caspase recruitment domain (ARC) in the brain. FASEB J. 2003, 17 (3), 494-496
37. Weinreb, O.; Amit, T.; Bar-Am, O.; Sagi, Y.; Mandel, S.; Youdim, M.B. Involvement of multiple survival signal transduction pathways in the neuroprotective, neurorescue and APP processing activity of rasagiline and its propargyl moiety. J. Neural Transm. Suppl. 2006, 70, 457-465
38. Zhang, W. J.; Wei, H.; Hagen, T.; Frei, B. Alpha-lipoic acid, attenuates LPS-induced inflammatory responses by activating the phosphoinositide 3-kinase/Akt signaling pathway. Proc. Natl. Acad. Sci. U.S.A. 2007, 104 (10), 4077-4082
39. Joseph, J. A.; Fisher, D. R.; Carey, A.; Szprengiel, A. The M3 muscarinic receptor i3 domain confers oxidative stress protection on calcium regulation in transfected COS-7 cells. Aginc. Cell 2004, 3 (5), 263-271
40. Gubern, A.; Barcelo-Torns, M.; Barneda, D.; Lopez, J. M.; Masgrau, R.; Picatoste, F.; Chalfant, C. E.; Balsinde, J.; Balboa, M. A.; Claro, E., JNK and ceramide kinase govern the biogenesis of lipid droplets through activation of Group IVA phospholipase A2. J. Biol. Chem. 2009.
41. Furuchi, T.; Suzuki, T.; Sekine, M.; Katane, M.; Homma, H. Apoptotic inducers activate the release of D-aspartate through a hypotonic stimulus-triggered mechanism in PC12 cells. Arch. Biochem. Biophys. 2009, 490(2), 118-128
42. Ferrer, I.; Blanco, R.; Carmona, M.; Puig, B.; Dominguez, I.; Vinals, F. Active, phosphorylation-dependent MAP kinases, MAPK/ERK, SAPK/JNK and p38, and specific transcription factor substrates are differentially expressed following systemic administration of kainic acid to the adult rat. Acta Neuropathol. (Berlin) 2002, 103 (4), 391-407.
43. Mendelson, K. G.; Contois, L. R.; Tevosian, S. G.; Davis, R. J.; Paulson, K. E. Independent regulation of JNK/p38 mitogen-activated protein kinases by metabolic oxidative stress in the liver. Proc. Natl. Asad. Sci. U.S.A. 1996, 93 (23), 12908-12913
44. Chen, Y.; Hatalski, C. G.; Brunson, K. L.; Baram, T. Z. Rapid phosphorylation of the CRE binding protein precedes stress-induced activation of the corticotropin releasing hormone gene in medial parvocellular hypothalamic neurons of the immature rat. Brain Res. Mol. Brain Res. 2001, 96 (1-2), 39-49.
45. Cho, J.; Cooke, C. E.; Proveaux, W. A retrospective review of the effect of COX-2 inhibitors on blood pressure change. Am. J. Ther. 2003, 10(5), 311-317
46. Reunanen, N.; Westermarck, J.; Hakkinen, L.; Holmstrom, T. H.; Elo, I.; Eriksson, J. E.; Kahari, V. M. Enhancement of fibroblast collagenase (matrix metalloproteinase-1) gene expression by ceramide is mediated by extracellular signal-regulated and stressactivated protein kinase pathways. J. Biol. Chem. 1998, 273 (9), 5137-5145
47. Willaime-Morawek, S.; Arbez, N.; Mariani, J.; Brugg, B. IGF-I protects cortical neurons against ceramide-induced apoptosis via activation of the PI-3K/Akt and ERK pathways; is this protection independent of CREB and Bcl-2? Brain Res. Mol. Brain Res. 2005, 142 (2), 97-106.
48. Joseph, J. A.; Denisova, N.; Fisher, D.; Bickford, P.; Prior, R.; Cao, G. Age-related neurodegeneration and oxidative stress: putative nutritional intervention. Neurol. Clin. 1998, 16 (3), 747-755
49. Joseph, J.; Shukitt-Hale, B.; Denisova, N. A.; Martin, A.; Perry, G.; Smith, M. A. Copernicus revisited: amyloid beta in Alzheimer's disease. Neurobiol. Aging. 2001, 22 (1), 131-146
50. 2+-ATPase: relevance to gangliosidoses. J. Neurochem. 2008, 104 (1), 140-146
51. 2+. Ann. N. Y. Acad. Sci. 1994, 746, 308-321.
52. Price, K. A.; Crouch, P. J.; Donnelly, P. S.; Masters, C. L.; White, A. R.; Curtain, C. C. Membrane-targeted strategies for modulating APP and Abeta-mediated toxicity. J. Cell. Mol. Med. 2009, 13 (2), 249-261
53. Fraga, C. G. Plant polyphenols: how to translate their in vitro antioxidant actions to in vivo conditions. IUBMB Life 2007, 59 (4-5), 308-315
54. Conseil, G.; Baubichon-Cortay, H.; Dayan, G.; Jault, J. M.; Barron, D.; Di Pietro, A. Flavonoids: a class of modulators with bifunctional interactions at vicinal ATP- and steroid-binding sites on mouse P-glycoprotein. Proc. Natl. Acad. Sci. U.S.A. 1998, 95, 9831-9836.
55. Lancon, A.; Demias, D.; Osman, H.; Thenot, J. P.; Jannin, B.; Latruffe, N. Human hepatic cell uptake of resveratrol: involvement of both passive diffusion and carrier-mediated process. Biochem. Biophys. Res. Commun. 2004, 316 (4), 1132-1137
56. Rosenkranz, S.; Knirel, D.; Dietrich, H.; Flesch, M.; Erdmann, E.; Bohm, M. Inhibition of the PDGF receptor by red wine flavonoids provides a molecular explanation for the "French paradox". FASEB J. 2002, 16 (14), 1958-1960
57. Tachibana, H.; Koga, K.; Fujimura, Y.; Yamada, K. A receptor for green tea polyphenol EGCG. Nat. Struct. Mol. Biol. 2004, 11 (4), 380-381
58. Erlejman, A. G.; Verstraeten, S. V.; Fraga, C. G.; Oteiza, P. I. The interaction of flavonoids with membranes: potential determinant of flavonoid antioxidant effects. Free Radical Res. 2004, 38 (12), 1311-1320
59. Goni, F. M.; Contreras, F. X.; Montes, L. R.; Sot, J.; Alonso, A. Biophysics (and sociology) of ceramides. Biochem. Soc. Symp. 2005, 72, 177-188.
60. Worgall, T. S. Regulation of lipid metabolism by sphingolipids. Subcell. Biochem. 2008, 49, 371-385.
61. Krikorian, R.; Nash, T. A.; Shidler, M. D.; Shukitt-Hale, B.; Joseph, J. A. Concord grape juice supplementation improves memory function in older adults. Br. J. Nutr. 2009, 23, 1-5.