Human trypsinogens in the pancreas and in cancer

Scandinavian Journal of Clinical and Laboratory Investigation

Volumn 70, Issue 2, 2010, Pages 136-143

  Itkonen, Outi ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Immunoassay; Mass spectrometry; Monoclonal antibodies; Serine endopeptidases; Tumor markers

Indexed keywords

ISOENZYME; TRYPSINOGEN; TRYPSINOGEN 1; TRYPSINOGEN 2; TYROSINE; UNCLASSIFIED DRUG;

ACUTE PANCREATITIS; BLOOD LEVEL; CANCER CELL CULTURE; COLON CARCINOMA; CONCENTRATION (PARAMETERS); DIAGNOSTIC PROCEDURE; DISEASE ASSOCIATION; DISEASE MARKER; ENZYME SUBSTRATE; HUMAN; IMMUNOASSAY; ION EXCHANGE; METASTASIS; OVARY CYST; PANCREAS CANCER; PANCREATICODUODENECTOMY; PRIORITY JOURNAL; REVIEW; SULFATION; TISSUE INJURY;

HUMANS; ISOENZYMES; NEOPLASMS; PANCREAS; TRYPSINOGEN;

EID: 77949822304     PISSN: 00365513     EISSN: 15027686     Source Type: Journal    
DOI: 10.3109/00365511003615317     Document Type: Review

References (51)

1. Rinderknecht H, Renner IG, Carmack C. Trypsinogen variants in pancreatic juice of healthy volunteers, chronic alcoholics, and patients with pancreatitis and cancer of the pancreas. Gut 1979;20:886-891
2. Scheele G, Bartelt D, Bieger W. Characterization of human exocrine pancreatic proteins by two-dimensional isoelectric focusing/sodium dodecyl sulfate gel electrophoresis. Gastroenterology 1981;80:461-473
3. Huhtala ML, Pesonen K, Kalkkinen N, Stenman UH. purification and characterization of a tumor-associated trypsin inhibitor from the urine of a patient with ovarian cancer. J Biol Chem 1982;257:13713-13716
4. Koivunen E, Huhtala ML, Stenman UH. Human ovarian tumor-associated trypsin. Its purification and characterization from mucinous cyst fluid and identification as an activator of pro-urokinase. J Biol Chem 1989;264:14095-14099
5. Bohe M, Borgstrom A, Lindstrom C, Ohlsson K. Pancreatic endoproteases and pancreatic secretory trypsin inhibitor immunoreactivity in human Paneth cells. J Clin Pathol 1986;39:786-793
6. Emi M, Nakamura Y, Ogawa M, Yamamoto T, Nishide T, Mori T, Matsubara K. Cloning, characterization and nucleotide sequences of two cDNAs encoding human pancreatic trypsinogens. Gene 1986;41:305-310
7. Rowen L, Koop BF, Hood L. The complete 685-kilobase DNA sequence of the human beta T cell receptor locus. Science 1996;272:1755-1762
8. Wiegand U, Corbach S, Minn A, Kang J, Muller-Hill B. Cloning of the cDNA encoding human brain trypsinogen and characterization of its product. Gene 1993;136:167-175
9. Szmola R, Sahin-Toth M. Chymotrypsin C (caldecrin) promotes degradation of human cationic trypsin: identity with Rinderknecht's enzyme Y. Proc Natl Acad Sci USA 2007;104:11227-11232
10. Nguyen TD, Moody MW, Steinhoff M, Okolo C, Koh DS, Bunnett NW. Trypsin activates pancreatic duct epithelial cell ion channels through proteinase-activated receptor-2. J Clin Invest 1999;103:261-269
11. Liotta LA, Tryggvason K, Garbisa S, Hart I, Foltz CM, Shafie S. Metastatic potential correlates with enzymatic degradation of basement membrane collagen. Nature 1980; 284:67-68
12. Paju A, Stenman UH. Biochemistry and clinical role of trypsinogens and pancreatic secretory trypsin inhibitor. Crit Rev Clin Lab Sci 2006;43:103-142
13. Koivunen E, Ristimaki A, Itkonen O, Osman S, Vuento M, Stenman UH. Tumor-associated trypsin participates in cancer cell-mediated degradation of extracellular matrix. Cancer Res 1991;51:2107-2112
14. Stenman M, Ainola M, Valmu L, Bjartell A, Ma G, Stenman UH, Sorsa T, Luukkainen R, Konttinen YT. Trypsin-2 degrades human type II collagen and is expressed and activated in mesenchymally transformed rheumatoid arthritis synovitis tissue. Am J Pathol 2005;167:1119-1124
15. Koivunen E, Itkonen O, Halila H, Stenman UH. Cyst fluid of ovarian cancer patients contains high concentrations of trypsinogen-2. Cancer Res 1990;50:2375-2378
16. Cederqvist K, Haglund C, Heikkila P, Sorsa T, Tervahartiala T, Stenman UH, Andersson S. Pulmonary trypsin-2 in the development of bronchopulmonary dysplasia in preterm infants. Pediatrics 2003;112:570-577
17. Ghosh D, Porter E, Shen B, Lee SK, Wilk D, Drazba J, Yadav SP, Crabb JW, Ganz T, Bevins CL. Paneth cell trypsin is the processing enzyme for human defensin-5. Nat Immunol 2002;3:583-590
18. Kazal LA, Spicer DS, Brahinsky RA. Isolation of a crystalline trypsin inhibitor-anticoagulant protein from the pancreas. J Am Chem Soc 1948;70:437-444
19. Rinderknecht H. Activation of pancreatic zymogens. Normal activation, premature intrapancreatic activation, protective mechanisms against inappropriate activation. Dig Dis Sci 1986;31:314-321
20. Stenman UH, Huhtala ML, Koistinen R, Seppala M. Immunochemical demonstration of an ovarian cancerassociated urinary peptide. Int J Cancer 1982;30:53-57
21. Yasuda T, Ogawa M, Murata A, Oka Y, Uda K, Mori T. Response to IL-6 stimulation of human hepatoblastoma cells: production of pancreatic secretory trypsin inhibitor. Biol Chem Hoppe Seyler 1990;371:95-100.
22. Pubols MH, Bartelt DC, Greene LJ. Trypsin inhibitor from human pancreas and pancreatic juice. J Biol Chem 1974;249: 2235-2242
23. Fukayama M, Hayashi Y, Koike M, Ogawa M, Kosaki G. Immunohistochemical localization of pancreatic secretory trypsin inhibitor in fetal and adult pancreatic and extrapancreatic tissues. J Histochem Cytochem 1986;34:227-235
24. Halila H, Huhtala ML, Schroder T, Kiviluoto T, Stenman UH. Pancreatic secretory trypsin inhibitor-like immunoreactivity in pancreatectomized patients. Clin Chim Acta 1985; 153:209-216
25. Itkonen O, Koivunen E, Hurme M, Alfthan H, Schroder T, Stenman UH. Time-resolved immunofl uorometric assays for trypsinogen-1 and 2 in serum reveal preferential elevation of trypsinogen-2 in pancreatitis. J Lab Clin Med 1990; 115:712-718
26. Lafont P, Guy-Crotte O, Paulin C, Galvain D, Mertani S, Figarella C, Barbier Y. A specifi c immunoradiometric assay of cationic trypsin(ogen) that does not recognize trypsinalpha- 1-proteinase inhibitor complex. Clin Chim Acta 1995; 235:197-206.
27. Kukor Z, Toth M, Sahin-Toth M. Human anionic trypsinogen: properties of autocatalytic activation and degradation and implications in pancreatic diseases. Eur J Biochem 2003; 270:2047-2058
28. Geokas MC, Largman C, Brodrick JW, Johnson JH. Determination of human pancreatic cationic trypsinogen in serum by radioimmunoassay. Am J Physiol 1979;236:E77-83.
29. Florholmen J, Jorde R, Olsen RL, Kolmannskog S, Burhol PG. Radioimmunoassay of cationic trypsin-like immunoreactivity in man. Scand J Gastroenterol 1984;19:613-621
30. Borgstrom A, Ohlsson K. Radioimmunological determination and characterization of cathodal trypsin-like immunoreactivity in normal human plasma. Scand J Clin Lab Invest 1976;36:809-814
31. Kimland M, Russick C, Marks WH, Borgstrom A. Immunoreactive anionic and cationic trypsin in human serum. Clin Chim Acta 1989;184:31-46.
32. Largman C, Brodrick JW, Geokas MC, Johnson JH. Demonstration of human pancreatic anionic trypsinogen in normal serum by radioimmunoassay. Biochim Biophys Acta 1978;543:450-454
33. Petersson U, Appelros S, Borgstrom A. Different patterns in immunoreactive anionic and cationic trypsinogen in urine and serum in human acute pancreatitis. Int J Pancreatol 1999;25:165-170
34. Itkonen O, Stenman UH, Osman S, Koivunen E, Halila H, Schroder T. Serum samples from pancreatectomized patients contain trypsinogen immunoreactivity. J Lab Clin Med 1996;128:98-102.
35. Koshikawa N, Hasegawa S, Nagashima Y, Mitsuhashi K, Tsubota Y, Miyata S, Miyagi Y, Yasumitsu H, Miyazaki K. Expression of trypsin by epithelial cells of various tissues, leukocytes, and neurons in human and mouse. Am J Pathol 1998;153:937-944
36. Kloppel G, Adsay NV, Klimstra DS. Pancreatitis: an introduction to history, etiology and pathogenesis. Semin Diagn Pathol 2004;21:219-220
37. Whitcomb DC, Gorry MC, Preston RA, Furey W, Sossenheimer MJ, Ulrich CD, Martin SP, Gates LK,Jr, Amann ST, Toskes PP, Liddle R, McGrath K, Uomo G, Post JC, Ehrlich GD. Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene. Nat Genet 1996;14:141-145
38. Gaboriaud C, Serre L, Guy-Crotte O, Forest E, Fontecilla-Camps JC. Crystal structure of human trypsin 1: unexpected phosphorylation of Tyr151. J Mol Biol 1996;259:995-1010.
39. Itkonen O, Helin J, Saarinen J, Kalkkinen N, Ivanov KI, Stenman UH, Valmu L. Mass spectrometric detection of tyrosine sulfation in human pancreatic trypsinogens, but not in tumor-associated trypsinogen. FEBS J 2008;275: 289-301.
40. Sahin-Toth M, Kukor Z, Nemoda Z. Human cationic trypsinogen is sulfated on Tyr154. FEBS J 2006;273:5044-5050
41. Szilagyi L, Kenesi E, Katona G, Kaslik G, Juhasz G, Graf L. Comparative in vitro studies on native and recombinant human cationic trypsins. Cathepsin B is a possible pathological activator of trypsinogen in pancreatitis. J Biol Chem 2001;276:24574-24580
42. Riordan JR, Rommens JM, Kerem B, Alon N, Rozmahel R, Grzelczak Z, Zielenski J, Lok S, Plavsic N, Chou JL. identification of the cystic fi brosis gene: cloning and characterization of complementary DNA. Science 1989;245: 1066-1073
43. Castellani C, Bonizzato A, Mastella G. CFTR mutations and IVS8-5T variant in newborns with hypertrypsinaemia and normal sweat test. J Med Genet 1997;34:297-301.
44. Petersson U, Borgstrom A. Characterization of immunoreactive trypsinogen activation peptide in urine in acute pancreatitis. Jop 2006;7:274-282
45. Hedstrom J, Sainio V, Kemppainen E, Haapiainen R, Kivilaakso E, Schroder T, Leinonen J, Stenman UH. Serum complex of trypsin 2 and alpha 1 antitrypsin as diagnostic and prognostic marker of acute pancreatitis: clinical study in consecutive patients.see comment. BMJ 1996;313:333-337
46. Hedstrom J, Korvuo A, Kenkimaki P, Tikanoja S, Haapiainen R, Kivilaakso E, Stenman UH. Urinary trypsinogen-2 test strip for acute pancreatitis. Lancet 1996;347:729-730
47. Lieberman JM, Marks WH, Stuart FP, Abecassis MM, Florence LS, Kauffman D. Co-monitoring serum anodal trypsinogen, serum amylase, and serum creatinine accurately differentiates rejection from other causes of allograft dysfunction after simultaneous pancreas-kidney transplantation. Transplant Proc 1997;29:676-677
48. Durie PR, Forstner GG, Gaskin KJ,Weizman Z, Kopelman HR, Ellis L, Largman C. Elevated serum immunoreactive pancreatic cationic trypsinogen in acute malnutrition: evidence of pancreatic damage. J Pediatr 1985;106:233-238
49. Yamamoto H, Iku S, Adachi Y, Imsumran A, Taniguchi H, Nosho K, Min Y, Horiuchi S, Yoshida M, Itoh F, Imai K. Association of trypsin expression with tumour progression and matrilysin expression in human colorectal cancer. J Pathol 2003;199:176-184
50. Diederichs S, Bulk E, Steffen B, Ji P, Tickenbrock L, Lang K, Zanker KS, Metzger R, Schneider PM, Gerke V, Thomas M, Berdel WE, Serve H, Muller-Tidow C. S100 family members and trypsinogens are predictors of distant metastasis and survival in early-stage non-small cell lung cancer. Cancer Res 2004;64:5564-5569
51. Lempinen M, Isoniemi H, Makisalo H, Nordin A, Halme L, Arola J, Hockerstedt K, Stenman UH. Enhanced detection of cholangiocarcinoma with serum trypsinogen-2 in patients with severe bile duct strictures. J Hepatol 2007; 47:677-683