Particle formation in supercritical fluids-Scale-up problem

Chemical Engineering Research and Design

Volumn 88, Issue 3, 2010, Pages 331-341

  Bałdyga, Jerzy ^a   Czarnocki, Rafał ^b   Shekunov, Boris Y ^c   Smith, Keith B ^d  

^a WARSAW UNIVERSITY OF TECHNOLOGY   (Poland)

^b ASTRAZENECA   (United Kingdom)

^c BRISTOL MYERS SQUIBB   (United States)

^d GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Pharmaceutical powders; Precipitation; Scale up; Supercritical fluids; Twin fluid nozzle

Indexed keywords

ANTI-SOLVENTS; ANTISOLVENT PRECIPITATION; CFD MODELLING; CFD SIMULATIONS; CRITICAL PRESSURES; ETHANOL SOLUTIONS; EXPERIMENTAL DATA; EXPERIMENTAL INVESTIGATIONS; MICRO-MIXING; MIXING CHAMBER; MODEL DRUGS; NUMERICAL SIMULATION; PARACETAMOL; PARTICLE FORMATIONS; PARTICLE GROWTH; PHARMACEUTICAL POWDER; POPULATION BALANCE EQUATION; PRECIPITATION; PRECIPITATION PROCESS; PRECIPITATION VESSELS; RESIDUAL FLUIDS; SCALE-UP; SCALING-UP; SOLUTION ENHANCED DISPERSION BY SUPERCRITICAL FLUIDS; SUBSTRATE SOLUTION; SUPERCRITICAL CO; SUPERSATURATED SOLUTIONS; TWIN-FLUID; TWO-COMPONENT;

BARIUM; COMPUTATIONAL FLUID DYNAMICS; COMPUTER SIMULATION; CRYSTALLIZATION; DRUG PRODUCTS; EFFLUENT TREATMENT; ETHANOL; NOZZLES; PRECIPITATION (CHEMICAL); SUPERCRITICAL FLUIDS;

SUPERCRITICAL FLUID EXTRACTION;

EID: 77949772937     PISSN: 02638762     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cherd.2010.01.019     Document Type: Article

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