Synthesis and cytotoxic evaluation of disubstituted N-acylhydrazones pyrazinecarbohydrazide derivatives

Letters in Drug Design and Discovery

Volumn 7, Issue 4, 2010, Pages 275-280

  De Ferreira, Marcelle L ^a,b   Candéa, André L P ^a   Henriques, Maria Das Graças M De O ^a   Kaiser, Carlos R ^b   Lima, Camilo H Da S ^a,b   De Souza, Marcus V N ^a  

^a INSTITUTO OSWALDO CRUZ   (Brazil)

^b FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

Drugs; N acylhydrazones; Pyrazine; Tuberculosis

Indexed keywords

BCG VACCINE; N' [(2 HYDROXY 3 METHOXYPHENYL)METHYLIDENE] 2 PYRAZINECARBOHYDRAZIDE; N' [(2,3 DICHLOROPHENYL)METHYLIDENE] 2 PYRAZINECARBOHYDRAZIDE; N' [(2,3 DIMETHOXYHENYL)METHYLIDENE] 2 PYRAZINECARBOHYDRAZIDE; N' [(2,4 DICHLOROPHENYL)METHYLIDENE] 2 PYRAZINECARBOHYDRAZIDE; N' [(2,4 DIFLUOROPHENYL)METHYLIDENE] 2 PYRAZINECARBOHYDRAZIDE; N' [(2,4 DIHYDROXYPHENYL)METHYLIDENE] 2 PYRAZINECARBOHYDRAZIDE; N' [(2,4 DIMETHOXYHENYL)METHYLIDENE] 2 PYRAZINECARBOHYDRAZIDE; N' [(2,4 DIMETHYLPHENYL)METHYLIDENE] 2 PYRAZINECARBOHYDRAZIDE; N' [(2,5 DIHYDROXYPHENYL)METHYLIDENE] 2 PYRAZINECARBOHYDRAZIDE; N' [(2,5 DIMETHOXYHENYL)METHYLIDENE] 2 PYRAZINECARBOHYDRAZIDE; N' [(2,6 DICHLOROPHENYL)METHYLIDENE] 2 PYRAZINECARBOHYDRAZIDE; N' [(3 HYDROXY 4 METHOXYPHENYL)METHYLIDENE] 2 PYRAZINECARBOHYDRAZIDE; N' [(3 METHOXY 4 HYDROXYPHENYL)METHYLIDENE] 2 PYRAZINECARBOHYDRAZIDE; N' [(3,4 DICHLOROPHENYL)METHYLIDENE] 2 PYRAZINECARBOHYDRAZIDE; N' [(3,4 DIHYDROXYPHENYL)METHYLIDENE] 2 PYRAZINECARBOHYDRAZIDE; N' [(3,4 DIMETHOXYHENYL)METHYLIDENE] 2 PYRAZINECARBOHYDRAZIDE; N' [(3,5 DIMETHOXYHENYL)METHYLIDENE] 2 PYRAZINECARBOHYDRAZIDE; PYRAZINAMIDE; PYRAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CELL CULTURE; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG SYNTHESIS; MACROPHAGE; MINIMUM INHIBITORY CONCENTRATION; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION;

EID: 77949765257     PISSN: 15701808     EISSN: None     Source Type: Journal    
DOI: 10.2174/157018010790945814     Document Type: Article

References (11)

1. World Health Organization, Global Tuberculosis Control: epidemiology, strategy, financing (Genebra: WHO, 2009), p. 303.
2. de Souza, M. V. N. Current status and future prospects for new therapies for pulmonary tuberculosis. Curr. Opin. Pulm. Med., 2006, 12(3), 167-171.
3. Coates, A.R.M.; Hu, Y. Targeting non-multiplying organisms as a way to develop novel antimicrobials. Trends Pharmacol. Sci., 2008, 29(3), 143-150.
4. de Souza, M. V. N. Promising drugs against tuberculosis. Recent. Pat. Antiinfect. Drug Discov., 2006, 1(1), 33-44.
5. Ginsberg, A. M.; Spigelman, M. Challenges in tuberculosis drug research and development. Nat. Med., 2007, 13(3), 290-294.
6. Vergara, F. M. F.; Lima, C. H. S.; Henriques, M. G. M. O.; Candea, A. L. P.; Lourenço, M. C. S.; Ferreira, M. L.; Kaiser, C. R.; de Souza, M. V. N. Synthesis and antimycobacterial activity of N'-[(E)-(monosubstituted- benzylidene)]-2-pyrazinecarbohydrazide derivatives. Eur. J. Med. Chem., 2009, 44, 4954-4959.
7. Lima, C. H. S.; Kaiser, C. R.; de Souza, M. V. N.; Wardell, J. L.; Wardell, S. M. S. V.; (Pyrazinecarbonyl)hydrazone halobenzaldehydes: supramolecular arrays generated by face to face stacking of ribbons, formed from C-H-O interactions. Z. Kristallogr, 2009, 224, 506-514.
8. Govindarajan, R.; Jameela, H. J.; Bhat, A. R. Synthesis of azetidinone and thiazolidinone derivatives of pyrazinoic acid for possible antitubercular, antifungal and antibacterial activity. J. Heterocycl. Chem., 2003, 12(3), 229-232.
9. Carvalho, M. V.; Penido, C.; Siani, A. C.; Valente, L. M. M.; Henriques, M. G. M. O. Investigations on the anti-inflammatory and anti-allergic activities of the leaves of Uncaria guianensis (Aublet) J. F. Gmelin. Inflammopharmacology, 2006, 14(1-2), 48-56.
10. Souza, M. C.; Siani, A. C.; Ramos, M. F. S.; Menezes-de-Lima, O., Jr.; Henriques, M. G. M. O. Evaluation of anti-inflammatory activity of essential oils from two asteraceae species. Die Pharmazie, 2003, 58(8), 582-586.
11. Wardell, S. M. S. V.; de Souza, M. V. N.; Wardell, J. L.; Low, J. N.; Glidewell, C. Pyrazine-2-carbohydrazide: a three-dimensional hydrogen-bonded framework structure. Acta Crystallogr. E., 2006, E62(9), 3765-3767.