Acute and subacute toxicity study of ethanolic extract of the stem bark of Faidherbia albida (DEL) A. chev (mimosoidae) in rats

African Journal of Biotechnology

Volumn 9, Issue 8, 2010, Pages 1218-1224

  Oluwakanyinsola, Salawu A ^a   Adeniyi, Tijani Y ^a   Akingbasote, James A ^a   Florence, Oga E ^a  

^a NATIONAL INSTITUTE FOR PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (Nigeria)

Author keywords

Faidherbia albida; Haematology; Liver function; Testes; Toxicity

Indexed keywords

FAIDHERBIA ALBIDA EXTRACT; PLANT EXTRACT; SODIUM CHLORIDE; UNCLASSIFIED DRUG;

ACUTE TOXICITY; ANALYTIC METHOD; ANALYTICAL PARAMETERS; ARTICLE; BARK; BIOCHEMISTRY; CONTROLLED STUDY; DOSE RESPONSE; FLUID INTAKE; FOOD INTAKE; HEMATOLOGY; LD 50; MALE; MALE GENITAL SYSTEM; NONHUMAN; ORGAN WEIGHT; PLANT STEM; RAT; TOXICITY; WEIGHT CHANGE;

FAIDHERBIA ALBIDA; RATTUS;

EID: 77949736648     PISSN: None     EISSN: 16845315     Source Type: Journal    
DOI: 10.5897/ajb09.748     Document Type: Article

References (30)

1. Berhaut J (1975). Flore Illustree du Senegal, Dicotyledones, Vol. 4, Ficoidees a Legumineuses, Dakar.
2. Boury NJ (1962). Vegetaux utilises dans la medecine africaine dans la region do Richard-toll (Senegal), in Adam: Les plantes utiles en Afrique occidentale, Notes Afr. 93: 14-16.
3. nd Ed. Academic Press, London and New York.
4. th Ed. Boston, USA. pp. 543-558.
5. Dalziel JM (1937). The useful Plants of West Tropical Africa, ed. 1, Crown Agents for the Colonies, London.
6. Fanshawe DB (1962). Fifty Common trees of Northern Rhodesia, Govt Printer, Lusaka.
7. th Ed. Lippincott Williams and Wilkins. Philadelphia. p. 83.
8. Howes FN (1949). Vegetable gums and resins, Chronica Botanica, Waltham, Kew Bull. 1: 51-87.
9. Irvine FR (1961). Woody plants of Ghana. Oxford University Press. London.
10. Jackson G (1973). MSc. Re Fulani in Northern Nigeria: Herb. UCI (uned).
11. Kerharo J, Adam JG (1962b). Premier inventaire des plantes médicinales et toxicologiques de la Casamance (Sénégal), Ann. Pharm. Franc. 20: 726-44, 823-841.
12. Kerharo JA, Adam JG (1962a). La Pharmacopée Séné galaise Traditionelle. Plantes médicinales et toxiques, Vigot Frères, Paris.
13. Kubmarawa D, Ajoku GA, Enwerem NM, Okorie DA (2007). Preliminary Phytochemical and antimicrobial screening of 50 medicinal plants from Nigeria. Afr. J. Biotechnol. 6(14): 1690-1696.
14. Lorke D (1983). A New Approach to Practical Acute Toxicity Testing. Arch. Toxicol. 54: 275-287.
15. rd Ed. Taylor and Francis. Philadelphia, USA. pp. 184-251.
16. th Ed. Philadelphia: W.B. Saunders, pp. 701-718
17. Mitruka BM, Rawnsley HM (1993). Clinical Biochemical and Hematological Reference Values in Normal Experimental animals. In: Ernest D. Olfert; Brenda M. Cross; and A. Ann McWilliam Ed. Guide to the care and use of experimental Animals. 1: appendix iv: a publication of the Canadian Council on Animal Care.
18. th Ed. Philadelphia: W.B. Saunders, pp. 549-593.
19. Moss DW (1987). Diagnostic aspect of Alkaline Phosphatase and its isoenzymes. Clin. Biochem. 20: 225-230.
20. Mulofwa J, Simute S, Tengnäs B (1994). Agroforestry: Manual for Extension Workers in Southern Province, Zambia. Swedish International Development Authority (SIDA), Regional Soil Conservation Unit (RCSU), Nairobi, Kenya. Tech. Handbook No. 4. Appendix 3, p. 199
21. th ed. Philadelphia: W.B. Saunders, pp. 253-267.
22. th ed. Philadelphia: WB Saunders. pp. 162-193.
23. th December, 2008)
24. th Ed. Philadelphia: F. A. Davis, pp. 1-6.
25. Singha SC (1965). Medicinal Plants of Nigeria, Nigerian National Press, Apapa.
26. Tijani AY, Uguru MO, Salawu OA (2008). Anti-pyretic, anti-inflammatory and anti-diarrhoeal properties of Faidherbia albida in rats. Afr. J. Biotech. 7(6): 696-700.
27. Tijani AY, Uguru MO, Salawu OA, Abubakar A, Onyekwelu NO, Akingbasote JA (2009). Effect of Faidherbia albida on some biochemical parameters of rats infected with Trypanosoma brucei brucei. Afr. J. Pharm. Pharmacol. 3(1): 26-30.
28. Vandenbelt RJ (1991). Rooting systems of western and southern African Faidherbia albida (Del.) A. Chev. (syn. Acacia albida Del.) A comparative analysis with biogeographic implications. Agroforesry Systems. Springer Netherlands. 14(3): 233-244.
29. Wickens GE (1969). A study of Acacia albida Del. (Mimosoidae). Kew Bull. 23(2): 181-202
30. th ed, W.A. Applied Therapeutics, Inc. pp. 14-20.