Ultrastructure of hippocampal field CA1 in rats after status epilepticus induced by systemic administration of kainic acid

Neuroscience and Behavioral Physiology

Volumn 40, Issue 2, 2010, Pages 127-130

  Kotariya, N T ^a   Bikashvili, T Z ^a   Zhvaniya, M G ^a   Chkhikvishvili, Ts G ^a  

^a Georgia   (Georgia)

Author keywords

Field CA1; Hippocampus; Kainic acid; Status epilepticus; Ultrastructure

Indexed keywords

GLYCOGEN; KAINIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTROCYTE; BRAIN MITOCHONDRION; CELL STRUCTURE; CELL VACUOLE; DENDRITIC SPINE; EPILEPTIC STATE; HIPPOCAMPAL CA1 REGION; INTERNEURON; MITOCHONDRIAL MEMBRANE; MITOCHONDRION SWELLING; NERVE CELL DEGENERATION; NERVE CELL NECROSIS; NEUROPATHOLOGY; NONHUMAN; POSTSYNAPTIC MEMBRANE; RAT; RIBOSOME; ROUGH ENDOPLASMIC RETICULUM; SYNAPSE VESICLE; ULTRASTRUCTURE; ANIMAL; CHEMICALLY INDUCED DISORDER; ELECTRON MICROSCOPY; HIPPOCAMPUS; MALE; MITOCHONDRION; NECROSIS; NERVE CELL; NEUROPIL; PATHOLOGY; SYNAPSE; TIME;

ANIMALS; CA1 REGION, HIPPOCAMPAL; INTERNEURONS; KAINIC ACID; MALE; MICROSCOPY, ELECTRON; MITOCHONDRIA; NECROSIS; NEURONS; NEUROPIL; RATS; STATUS EPILEPTICUS; SYNAPSES; TIME FACTORS;

EID: 77949734211     PISSN: 00970549     EISSN: 1573899X     Source Type: Journal    
DOI: 10.1007/s11055-009-9233-4     Document Type: Article

References (15)

1. N. N. Bogolepov, Brain Ultrastructure in Hypoxia [in Russian], Meditsina, Moscow (1979).
2. Y. Ben-Ari and R. Cossart, "Kainate, a double agent that generates seizures: two decades of progress", Trends Neurosci., 23, 580-587 (2000).
3. C. Charriaut-Marlangue and Y. Ben-Ari, "A cautionary note on the use of the TUNEL stain to determine apoptosis", NeuroReport, 7, No. 1, 61-67 (1995).
4. F. Doonan and T. G. Cotter, "Morphological assessment of apoptosis", Methods, 44, No. 3, 200-204 (2008). (Pubitemid 351296443)
5. D. G. Fujikawa, S. S. Shinmei, and B. Cai, "Kainic acid-induced seizures produce necrotic, not apoptotic neurons with internucleosomal DNA cleavage: implications for programmed cell death mechanisms", Neurosci., 98, No. 1, 41-53 (2000). (Pubitemid 30349142)
6. U. Heinemann, K. Bucheim, S. Gabriel, et al., "Cell death and metabolic activity during epileptiform discharges and status epilepticus in the hippocampus", Prog. Brain Res., 135, 197-200 (2002).
7. W. Jiang, B. Du, Z. Chi, et al., "Preliminary explorations of the role of mitochondrial proteins in refractory epilepsy: some findings from comparative genomics", J. Neurosci. Res., 85, No. 14, 3160-3170 (2007). (Pubitemid 350057372)
8. N. T. Kotaria, T. Bolkvadze, C. L. Chkhikhvisvili, et al., "Quantitative analysis of cells in rat hippocampus at different time-points after status epilepticus induced by kainic acid administration", Georgian J. Neurosci., 1, No. 5, 47-52 (2006).
9. W. S. Kunz, A. P. Kadin, S. Vielbaher, et al., "Mitochondrial complex 1 deficiency in the epileptic focus of patients with temporal lobe epilepsy", Ann. Neurol., 48, 766-773 (2000).
10. J. P. Leite, L. Neder, G. M. Arisi, et al., "Plasticity, synaptic strength, and epilepsy: what can we learn from ultrastructural data?" Epilepsia, 6, Supplement 5, 134-141 (2005). (Pubitemid 40962136)
11. M. A. Mikati, R. J. Abi-Habib, M. E. Sabban, et al., "Hippocampal programmed cell death after status epilepticus: evidence for NMDA receptor and ceramide mediated mechanism", Epilepsia, 44, 282-291 (2003). (Pubitemid 36343757)
12. H. Pollard, C. Charriaut-Marlangue, S. Cantagrel, et al., "Kainate acid-induced apoptotic cell death in hippocampal neurons", Neurosci., 63, 7-18 (1994). (Pubitemid 24333948)
13. C. Walter, B. L. Murphy, R. Y. Pun, et al., "Pilocarpine-induced seizures cause selective time-dependent changes to adult-generated hippocampal dentate granule cells", J. Neurosci., 27, No. 28, 7541-7552 (2007). (Pubitemid 47066571)
14. Yao-Chung Chuang, Y. W. Alice, Jui-Wei Lin, et al., "Mitochondrial dysfunction and ultrastructural damage in the hippocampus during kainic acid-induced status epilepticus in the rat", Epilepsia, 45, No. 10, 1202-1209 (2004). (Pubitemid 39350332)
15. B. Zhivotosky and S. Orrenius, "Assessment of apoptosis and necrosis by DNA fragmentation and morphological criteria", in: Curr. Protoc. Cell Biol., Chapter 18, Unit 18.3, pp. 207-221.