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Volumn 95, Issue 3, 2010, Pages 348-351

Pathophysiology and treatment of the myelodysplastic syndrome with isolated 5q deletion

Author keywords

[No Author keywords available]

Indexed keywords

GRANULOCYTE COLONY STIMULATING FACTOR; LENALIDOMIDE; MICRORNA; PROTEIN RPS14; RIBOSOME PROTEIN; UNCLASSIFIED DRUG;

EID: 77949732135     PISSN: 03906078     EISSN: 15928721     Source Type: Journal    
DOI: 10.3324/haematol.2009.019141     Document Type: Editorial
Times cited : (11)

References (25)
  • 1
    • 10744229499 scopus 로고    scopus 로고
    • Clinical, morphological, cytogenetic, and prognostic features of patients with myelodysplastic syndromes and del(5q) including band q31
    • Giagounidis AA, Germing U, Haase S, Hildebrandt B, Schlegelberger B, Schoch C, et al. Clinical, morphological, cytogenetic, and prognostic features of patients with myelodysplastic syndromes and del(5q) including band q31. Leukemia. 2004;18(1):113-9.
    • (2004) Leukemia , vol.18 , Issue.1 , pp. 113-119
    • Giagounidis, A.A.1    Germing, U.2    Haase, S.3    Hildebrandt, B.4    Schlegelberger, B.5    Schoch, C.6
  • 3
    • 0034665776 scopus 로고    scopus 로고
    • Isolation and characterization of hematopoietic progenitor/stem cells in 5q-deleted myelodysplastic syndromes: Evidence for involvement at the hematopoietic stem cell level
    • Nilsson L, Astrand-Grundstrom I, Arvidsson I, Jacobsson B, Hellstrom-Lindberg E, Hast R, et al. Isolation and characterization of hematopoietic progenitor/stem cells in 5q-deleted myelodysplastic syndromes: evidence for involvement at the hematopoietic stem cell level. Blood. 2000;96(6):2012-21.
    • (2000) Blood , vol.96 , Issue.6 , pp. 2012-2021
    • Nilsson, L.1    Astrand-Grundstrom, I.2    Arvidsson, I.3    Jacobsson, B.4    Hellstrom-Lindberg, E.5    Hast, R.6
  • 5
    • 33644538600 scopus 로고    scopus 로고
    • Cytolytic function and survival of natural killer cells are severely altered in myelodysplastic syndromes
    • Kiladjian JJ, Bourgeois E, Lobe I, Braun T, Visentin G, Bourhis JH, et al. Cytolytic function and survival of natural killer cells are severely altered in myelodysplastic syndromes. Leukemia. 2006;20(3):463-70.
    • (2006) Leukemia , vol.20 , Issue.3 , pp. 463-470
    • Kiladjian, J.J.1    Bourgeois, E.2    Lobe, I.3    Braun, T.4    Visentin, G.5    Bourhis, J.H.6
  • 6
    • 0037097597 scopus 로고    scopus 로고
    • Narrowing and genomic annotation of the commonly deleted region of the 5q- syndrome
    • Boultwood J, Fidler C, Strickson AJ, Watkins F, Gama S, Kearney L, et al. Narrowing and genomic annotation of the commonly deleted region of the 5q- syndrome. Blood. 2002;99(12):4638-41.
    • (2002) Blood , vol.99 , Issue.12 , pp. 4638-4641
    • Boultwood, J.1    Fidler, C.2    Strickson, A.J.3    Watkins, F.4    Gama, S.5    Kearney, L.6
  • 7
    • 38349088899 scopus 로고    scopus 로고
    • Identification of RPS14 as a 5q- syndrome gene by RNA interference screen
    • Ebert BL, Pretz J, Bosco J, Chang CY, Tamayo P, Galili N, et al. Identification of RPS14 as a 5q- syndrome gene by RNA interference screen. Nature. 2008;451(7176):335-9.
    • (2008) Nature , vol.451 , Issue.7176 , pp. 335-339
    • Ebert, B.L.1    Pretz, J.2    Bosco, J.3    Chang, C.Y.4    Tamayo, P.5    Galili, N.6
  • 8
    • 67650859652 scopus 로고    scopus 로고
    • Deletion 5q in myelodysplastic syndrome: A paradigm for the study of hemizygous deletions in cancer
    • Ebert BL. Deletion 5q in myelodysplastic syndrome: a paradigm for the study of hemizygous deletions in cancer. Leukemia. 2009; 23(7):1252-6.
    • (2009) Leukemia , vol.23 , Issue.7 , pp. 1252-1256
    • Ebert, B.L.1
  • 9
    • 73849121794 scopus 로고    scopus 로고
    • Starczynowski DT, Kuchenbauer F, Argiropoulos B, Sung S, Morin R, Muranyi A, et al. Identification of miR-145 and miR-146a as mediators of the 5q- syndrome phenotype. Nat Med. 2010;16(1):49-58.
    • Starczynowski DT, Kuchenbauer F, Argiropoulos B, Sung S, Morin R, Muranyi A, et al. Identification of miR-145 and miR-146a as mediators of the 5q- syndrome phenotype. Nat Med. 2010;16(1):49-58.
  • 10
    • 34547474047 scopus 로고    scopus 로고
    • Lenalidomide inhibits the malignant clone and up-regulates the SPARC gene mapping to the commonly deleted region in 5q- syndrome patients
    • Pellagatti A, Jadersten M, Forsblom AM, Cattan H, Christensson B, Emanuelsson EK, et al. Lenalidomide inhibits the malignant clone and up-regulates the SPARC gene mapping to the commonly deleted region in 5q- syndrome patients. Proc Natl Acad Sci USA. 2007; 104(27):11406-11.
    • (2007) Proc Natl Acad Sci USA , vol.104 , Issue.27 , pp. 11406-11411
    • Pellagatti, A.1    Jadersten, M.2    Forsblom, A.M.3    Cattan, H.4    Christensson, B.5    Emanuelsson, E.K.6
  • 11
    • 10644250277 scopus 로고    scopus 로고
    • SPARC and tumor growth: Where the seed meets the soil?
    • Framson PE, Sage EH. SPARC and tumor growth: where the seed meets the soil? J Cell Biochem. 2004;92(4):679-90.
    • (2004) J Cell Biochem , vol.92 , Issue.4 , pp. 679-690
    • Framson, P.E.1    Sage, E.H.2
  • 12
    • 73849128091 scopus 로고    scopus 로고
    • Barlow JL, Drynan LF, Hewett DR, Holmes LR, Lorenzo-Abalde S, Lane AL, et al. A p53-dependent mechanism underlies macrocytic anemia in a mouse model of human 5q- syndrome. Nat Med. 2010; 16(1):59-66.
    • Barlow JL, Drynan LF, Hewett DR, Holmes LR, Lorenzo-Abalde S, Lane AL, et al. A p53-dependent mechanism underlies macrocytic anemia in a mouse model of human 5q- syndrome. Nat Med. 2010; 16(1):59-66.
  • 13
    • 77949725680 scopus 로고    scopus 로고
    • Garderet L, Kobari L, Mazurier C, De Witte C, Giarratana M-C, Pérot C, et al. Unimpaired terminal erythroid differentiation and preserved enucleation capacity in myelodysplastic 5q(del) clones: a single cell study. Haematologica. 2010;95(3):398-405.
    • Garderet L, Kobari L, Mazurier C, De Witte C, Giarratana M-C, Pérot C, et al. Unimpaired terminal erythroid differentiation and preserved enucleation capacity in myelodysplastic 5q(del) clones: a single cell study. Haematologica. 2010;95(3):398-405.
  • 14
    • 77949699420 scopus 로고    scopus 로고
    • Ximeri M, Galanopoulos A, Klaus M, Parcharidou A, Giannikou K, Psyllaki M, et al. on behalf of the Hellenic MDS Study Group. Effect of lenalidomide therapy on hematopoiesis of patients with myelodysplastic syndrome associated with chromosome 5q deletion. Haematologica. 2010;95(3):406-14.
    • Ximeri M, Galanopoulos A, Klaus M, Parcharidou A, Giannikou K, Psyllaki M, et al. on behalf of the Hellenic MDS Study Group. Effect of lenalidomide therapy on hematopoiesis of patients with myelodysplastic syndrome associated with chromosome 5q deletion. Haematologica. 2010;95(3):406-14.
  • 15
    • 12244277678 scopus 로고    scopus 로고
    • Evidence- and consensus-based practice guidelines for the therapy of primary myelodysplastic syndromes. A statement from the Italian Society of Hematology
    • Alessandrino EP, Amadori S, Barosi G, Cazzola M, Grossi A, Liberato LN, et al. Evidence- and consensus-based practice guidelines for the therapy of primary myelodysplastic syndromes. A statement from the Italian Society of Hematology. Haematologica. 2002;87(12):1286-306.
    • (2002) Haematologica , vol.87 , Issue.12 , pp. 1286-1306
    • Alessandrino, E.P.1    Amadori, S.2    Barosi, G.3    Cazzola, M.4    Grossi, A.5    Liberato, L.N.6
  • 16
    • 0037272767 scopus 로고    scopus 로고
    • Guidelines for the diagnosis and therapy of adult myelodysplastic syndromes
    • Bowen D, Culligan D, Jowitt S, Kelsey S, Mufti G, Oscier D, et al. Guidelines for the diagnosis and therapy of adult myelodysplastic syndromes. Br J Haematol. 2003;120(2):187-200.
    • (2003) Br J Haematol , vol.120 , Issue.2 , pp. 187-200
    • Bowen, D.1    Culligan, D.2    Jowitt, S.3    Kelsey, S.4    Mufti, G.5    Oscier, D.6
  • 17
    • 77949725285 scopus 로고    scopus 로고
    • NCCN Clinical Practice Guidelines in Oncology, Myelodysplastic Syndromes, Available from
    • NCCN Clinical Practice Guidelines in Oncology / Myelodysplastic Syndromes. 2008 [Available from: www.nccn.org]
    • (2008)
  • 18
    • 77949672044 scopus 로고    scopus 로고
    • The Nordic MDS Group Care Program, Available from
    • The Nordic MDS Group Care Program. 2008 [Available from: www.nmds.org/ez4/index.php?/nmds/Nordic-Care-Programme]
    • (2008)
  • 19
    • 33749438404 scopus 로고    scopus 로고
    • Lenalidomide in the myelodysplastic syndrome with chromosome 5q deletion
    • List A, Dewald G, Bennett J, Giagounidis A, Raza A, Feldman E, et al. Lenalidomide in the myelodysplastic syndrome with chromosome 5q deletion. N Engl J Med. 2006;355(14):1456-65.
    • (2006) N Engl J Med , vol.355 , Issue.14 , pp. 1456-1465
    • List, A.1    Dewald, G.2    Bennett, J.3    Giagounidis, A.4    Raza, A.5    Feldman, E.6
  • 20
    • 37549064394 scopus 로고    scopus 로고
    • Targeted therapies in myelodysplastic syndrome
    • Melchert M, List A. Targeted therapies in myelodysplastic syndrome. Semin Hematol. 2008;45(1):31-8.
    • (2008) Semin Hematol , vol.45 , Issue.1 , pp. 31-38
    • Melchert, M.1    List, A.2
  • 21
    • 77649303359 scopus 로고    scopus 로고
    • Patients with del(5q) MDS who fail to achieve sustained erythroid or cytogenetic remission after treatment with lenalidomide have an increased risk for clonal evolution and AML progression
    • Oct 24, Epub ahead of print
    • Gohring G, Giagounidis A, Busche G, Kreipe HH, Zimmermann M, Hellstrom-Lindberg E, et al. Patients with del(5q) MDS who fail to achieve sustained erythroid or cytogenetic remission after treatment with lenalidomide have an increased risk for clonal evolution and AML progression. Ann Hematol. 2009 Oct 24. [Epub ahead of print]
    • (2009) Ann Hematol
    • Gohring, G.1    Giagounidis, A.2    Busche, G.3    Kreipe, H.H.4    Zimmermann, M.5    Hellstrom-Lindberg, E.6
  • 22
    • 73149108856 scopus 로고    scopus 로고
    • Clonal heterogeneity in the 5q- syndrome: P53 expressing progenitors prevail during lenalidomide treatment and expand at disease progression
    • Jadersten M, Saft L, Pellagatti A, Gohring G, Wainscoat JS, Boultwood J, et al. Clonal heterogeneity in the 5q- syndrome: p53 expressing progenitors prevail during lenalidomide treatment and expand at disease progression. Haematologica. 2009;94(12):1762-6.
    • (2009) Haematologica , vol.94 , Issue.12 , pp. 1762-1766
    • Jadersten, M.1    Saft, L.2    Pellagatti, A.3    Gohring, G.4    Wainscoat, J.S.5    Boultwood, J.6
  • 23
    • 1942534043 scopus 로고    scopus 로고
    • The evolution of thalidomide and its IMiD derivatives as anticancer agents
    • Bartlett JB, Dredge K, Dalgleish AG. The evolution of thalidomide and its IMiD derivatives as anticancer agents. Nat Rev Cancer. 2004;4(4):314-22.
    • (2004) Nat Rev Cancer , vol.4 , Issue.4 , pp. 314-322
    • Bartlett, J.B.1    Dredge, K.2    Dalgleish, A.G.3
  • 24
    • 69149090140 scopus 로고    scopus 로고
    • A critical role for phosphatase haplodeficiency in the selective suppression of deletion 5q MDS by lenalidomide
    • Wei S, Chen X, Rocha K, Epling-Burnette PK, Djeu JY, Liu Q, et al. A critical role for phosphatase haplodeficiency in the selective suppression of deletion 5q MDS by lenalidomide. Proc Natl Acad Sci USA. 2009;106(31):12974-9.
    • (2009) Proc Natl Acad Sci USA , vol.106 , Issue.31 , pp. 12974-12979
    • Wei, S.1    Chen, X.2    Rocha, K.3    Epling-Burnette, P.K.4    Djeu, J.Y.5    Liu, Q.6
  • 25
    • 24344507215 scopus 로고    scopus 로고
    • Antiapoptotic role of growth factors in the myelodysplastic syndromes: Concordance between in vitro and in vivo observations
    • Tehranchi R, Fadeel B, Schmidt-Mende J, Forsblom AM, Emanuelsson E, Jadersten M, et al. Antiapoptotic role of growth factors in the myelodysplastic syndromes: concordance between in vitro and in vivo observations. Clin Cancer Res. 2005;11(17):6291-9.
    • (2005) Clin Cancer Res , vol.11 , Issue.17 , pp. 6291-6299
    • Tehranchi, R.1    Fadeel, B.2    Schmidt-Mende, J.3    Forsblom, A.M.4    Emanuelsson, E.5    Jadersten, M.6


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