Iron status is associated with carotid atherosclerotic plaques in middle-aged adults

Journal of Nutrition

Volumn 140, Issue 4, 2010, Pages 812-816

  Ahluwalia, Namanjeet ^a   Genoux, Annelise ^a   Ferrieres, Jean ^a   Perret, Bertrand ^a   Carayol, Marion ^a   Drouet, Ludovic ^b   Ruidavets, Jean Bernard ^a  

^a TOULOUSE UNIVERSITY HOSPITAL   (France)

^b HÔPITAL LARIBOISIÈRE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

FERRITIN; IRON; OROSOMUCOID;

ADULT; AGING; ARTICLE; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; CARDIOVASCULAR RISK; CAROTID ARTERY DISEASE; CASE CONTROL STUDY; CAUCASIAN; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; FERRITIN BLOOD LEVEL; FRANCE; HUMAN; INFLAMMATION; IRON METABOLISM; MAJOR CLINICAL STUDY; MALE; RISK ASSESSMENT; RISK FACTOR;

ADULT; BIOLOGICAL MARKERS; CAROTID ARTERY DISEASES; CASE-CONTROL STUDIES; FEMALE; FERRITINS; HUMANS; IRON; MALE; MIDDLE AGED; RISK FACTORS;

EID: 77949719651     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.3945/jn.109.110353     Document Type: Article

References (38)

1. Sullivan JL. Iron and the sex difference in heart disease risk. Lancet. 1981;1:1293-4.
2. Zacharski LR, Ornstein DL, Woloshin S, Schwartz LM. Association of age, sex, and race with body iron stores in adults: analysis of NHANES III data. Am Heart J. 2000;140:98-104.
3. Lamb DJ, Leake DS. Iron released from transferrin at acidic pH can catalyse the oxidation of low density lipoprotein. FEBS Lett. 1994;352:15-8.
4. Pratico D, Pasin M, Barry OP, Ghiselli A, Sabatino G, Iuliano L, FitzGerald GA, Violi F. Iron-dependent human platelet activation and hydroxyl radical formation: involvement of protein kinase C. Circulation. 1999;99:3118-24.
5. Yuan XM, Brunk UT, Olsson AG. Effects of iron- and hemoglobinloaded human monocyte-derived macrophages on oxidation and uptake of LDL. Arterioscler Thromb Vasc Biol. 1995;15:1345-51.
6. Danesh J, Appleby P. Coronary heart disease and iron status: metaanalyses of prospective studies. Circulation. 1999;99:852-4.
7. Sempos CT. Do body iron stores increase the risk of developing coronary heart disease? Am J Clin Nutr. 2002;76:501-3.
8. Auer J, Rammer M, Berent R, Weber T, Lassnig E, Eber B. Body iron stores and coronary atherosclerosis assessed by coronary angiography. Nutr Metab Cardiovasc Dis. 2002;12:285-90.
9. Moore M, Folsom AR, Barnes RW, Eckfeldt JH. No association between serum ferritin and asymptomatic carotid atherosclerosis. The Atherosclerosis Risk in Communities (ARIC) Study. Am J Epidemiol. 1995;141:719-23.
10. Rauramaa R, Vaisanen S, Mercuri M, Rankinen T, Penttila I, Bond MG. Association of risk factors and body iron status to carotid atherosclerosis in middle-aged eastern Finnish men. Eur Heart J. 1994;15:1020-7.
11. Haidari M, Javadi E, Sanati A, Hajilooi M, Ghanbili J. Association of increased ferritin with premature coronary stenosis in men. Clin Chem. 2001;47:1666-72.
12. Kiechl S, Aichner F, Gerstenbrand F, Egger G, Mair A, Rungger G, Spogler F, Jarosch E, Oberhollenzer F, et al. Body iron stores and presence of carotid atherosclerosis. Results from the Bruneck Study. Arterioscler Thromb. 1994;14:1625-30.
13. Wolff B, Volzke H, Ludemann J, Robinson D, Vogelgesang D, Staudt A, Kessler C, Dahm JB, John U, et al. Association between high serum ferritin levels and carotid atherosclerosis in the study of health in Pomerania (SHIP). Stroke. 2004;35:453-7.
14. Knuiman MW, Divitini ML, Olynyk JK, Cullen DJ, Bartholomew HC. Serum ferritin and cardiovascular disease: a 17-year follow-up study in Busselton, Western Australia. Am J Epidemiol. 2003;158:144-9.
15. Sempos CT, Looker AC, Gillum RE, McGee DL, Vuong CV, Johnson CL. Serum ferritin and death from all causes and cardiovascular disease: the NHANES II Mortality Study. National Health and Nutrition Examination Study. Ann Epidemiol. 2000;10:441-8.
16. Kiechl S, Willeit J, Egger G, PoeweW, Oberhollenzer F. Body iron stores and the risk of carotid atherosclerosis: prospective results from the Bruneck study. Circulation. 1997;96:3300-7.
17. Klipstein-Grobusch K, Koster JF, Grobbee DE, Lindemans J, Boeing H, Hofman A, Witteman JC. Serum ferritin and risk of myocardial infarction in the elderly: the Rotterdam Study. Am J Clin Nutr. 1999;69:1231-6.
18. Salonen JT, Nyyssonen K, Korpela H, Tuomilehto J, Seppanen R, Salonen R. High stored iron levels are associated with excess risk of myocardial infarction in eastern Finnish men. Circulation. 1992;86:803-11.
19. van der A DL, Marx JJ, Grobbee DE, Kamphuis MH, Georgiou NA, van Kats-Renaud JH, Breuer W, Cabantchik ZI, Roest M, et al. Nontransferrin-bound iron and risk of coronary heart disease in postmenopausal women. Circulation. 2006;113:1942-9.
20. Magnusson MK, Sigfusson N, Sigvaldason H, Johannesson GM, Magnusson S, Thorgeirsson G. Low iron-binding capacity as a risk factor for myocardial infarction. Circulation. 1994;89:102-8.
21. Sun Q, Ma J, Rifai N, Franco OH, Rexrode KM, Hu FB. Excessive body iron stores are not associated with risk of coronary heart disease in women. J Nutr. 2008;138:2436-41.
22. Lipschitz DA, Cook JD, Finch CA. A clinical evaluation of serum ferritin as an index of iron stores. N Engl J Med. 1974;290:1213-6.
23. Tomkins A. Assessing micronutrient status in the presence of inflammation. J Nutr. 2003;133:S1649-55.
24. Ali MA, Luxton AW, Walker WH. Serum ferritin concentration and bone marrow iron stores: a prospective study. Can Med Assoc J. 1978;118:945-6.
25. Ahluwalia N, Lammi-Keefe CJ, Bendel RB, Morse EE, Beard JL, Haley NR. Iron deficiency and anemia of chronic disease in elderly women: a discriminant-analysis approach for differentiation. Am J Clin Nutr. 1995;61:590-6.
26. Lee DH, Zacharski LR, Jacobs DR Jr. Comparison of the serum ferritin and percentage of transferrin saturation as exposure markers of irondriven oxidative stress-related disease outcomes. Am Heart J. 2006;151:1247 e1-7.
27. Ahluwalia N, Drouet L, Ruidavets JB, Perret B, Amar J, Boccalon H, Hanaire-Broutin H, Ferrieres J. Metabolic syndrome is associated with markers of subclinical atherosclerosis in a French population-based sample. Atherosclerosis. 2006;186:345-53.
28. Bongard V, Elias A, Bal dit Sollier C, Ruidavets J, Boccalon H, Drouet L, Ferrieres J. Soluble intercellular adhesion molecule-1 is associated with carotid and femoral atherosclerosis but not with intima-media thickness in a population-based sample. Atherosclerosis. 2002;164:297-304.
29. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem. 1972;18:499-502.
30. Jacobs A, Miller F, Worwood M, Beamish MR, Wardrop CA. Ferritin in the serum of normal subjects and patients with iron deficiency and iron overload. BMJ. 1972;4:206-8.
31. Pang JH, Jiang MJ, Chen YL, Wang FW, Wang DL, Chu SH, Chau LY. Increased ferritin gene expression in atherosclerotic lesions. J Clin Invest. 1996;97:2204-12.
32. You SA, Wang Q. Ferritin in atherosclerosis. Clin Chim Acta. 2005;357:1-16.
33. Araujo JA, Romano EL, Brito BE, Parthe V, Romano M, Bracho M, Montano RF, Cardier J. Iron overload augments the development of atherosclerotic lesions in rabbits. Arterioscler Thromb Vasc Biol. 1995;15:1172-80.
34. Day SM, Duquaine D, Mundada LV, Menon RG, Khan BV, Rajagopalan S, Fay WP. Chronic iron administration increases vascular oxidative stress and accelerates arterial thrombosis. Circulation. 2003;107:2601-6.
35. Zacharski LR, Chow BK, Howes PS, Shamayeva G, Baron JA, Dalman RL, Malenka DJ, Ozaki CK, Lavori PW. Reduction of iron stores and cardiovascular outcomes in patients with peripheral arterial disease: a randomized controlled trial. JAMA. 2007;297:603-10.
36. Feelders RA, Vreugdenhil G, Eggermont AM, Kuiper-Kramer PA, van Eijk HG, Swaak AJ. Regulation of iron metabolism in the acute-phase response: interferon gamma and tumour necrosis factor alpha induce hypoferraemia, ferritin production and a decrease in circulating transferrin receptors in cancer patients. Eur J Clin Invest. 1998;28:520-7.
37. Ridker PM, Hennekens CH, Buring JE, Rifai N. C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. N Engl J Med. 2000;342:836-43.
38. Cook JD, Boy E, Flowers C, Daroca Mdel C. The influence of high-altitude living on body iron. Blood. 2005;106:1441-6.