Ductus venosus velocimetry in acute fetal acidemia and impending fetal death in a sheep model of increased placental vascular resistance

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 298, Issue 4, 2010, Pages

  Mäkikallio, Kaarin ^a   Acharya, Ganesh ^b,c   Erkinaro, Tiina ^a   Kavasmaa, Tomi ^a   Haapsamo, Mervi ^a   Huhta, James C ^b,c,d   Räsänen, Juha ^a,e  

^a UNIVERSITY OF OULU   (Finland)

^b UNIVERSITY OF TROMSØ   (Norway)

^c UNIVERSITY HOSPITAL OF NORTH NORWAY   (Norway)

^d Division of Pediatric Heart Surgery   (United States)

^e OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

Doppler ultrasound; Fetal physiology; Placental insufficiency

Indexed keywords

LACTIC ACID; OXYGEN;

ACID BASE BALANCE; ACIDEMIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ARTIFICIAL EMBOLISM; BLOOD FLOW; BLOOD GAS; CONTROLLED STUDY; DISEASE MODEL; DISEASE SEVERITY; DUCTUS VENOSUS; FETUS; FETUS BLOOD; FETUS DEATH; GESTATIONAL AGE; HEART OUTPUT; HYPOTENSION; HYPOXEMIA; MEASUREMENT; NONHUMAN; OXYGENATION; PLACENTA; PREGNANCY; PRIORITY JOURNAL; SHEEP; UTERINE ARTERY; VASCULAR RESISTANCE; VELOCIMETRY;

ANIMALS; ANOXIA; BLOOD FLOW VELOCITY; BLOOD PRESSURE; FATTY ACIDS; FEMALE; FETAL DEATH; FETUS; HEART RATE; MODELS, ANIMAL; PLACENTA; PREGNANCY; REGIONAL BLOOD FLOW; SHEEP; UMBILICAL VEINS; VASCULAR RESISTANCE; VEINS; VENA CAVA, INFERIOR;

EID: 77949713102     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.01299.2008     Document Type: Article

References (22)

1. Acharya G, Erkinaro T, Mäkikallio K, Lappalainen T, Räsänen J. Relationships between Doppler-derived umbilical artery absolute velocities, cardiac function, and placental volume blood flow and resistance in fetal sheep. Am J Physiol Heart Circ Physiol 286: H1266-H1272, 2004.
2. Acharya G, Räsänen J, Mäkikallio K, Erkinaro T, Kavasmaa T, Haapsamo M, Mertens L, Huhta JC. Metabolic acidosis decreases fetal myocardial isovolumic velocities in a chronic sheep model of increased placental vascular resistance. Am J Physiol Heart Circ Physiol 294: H498-H504, 2008.
3. Baschat AA, Guclu S, Kush ML, Gembruch U, Weiner CP, Harman CR. Venous Doppler in the prediction of acid-base status of growthrestricted fetuses with elevated placental blood flow resistance. Am J Obstet Gynecol 191: 277-284, 2004.
4. Bellotti M, Pennati G, De Gasperi C, Bozzo M, Battaglia FC, Ferrazzi E. Simultaneous measurements of umbilical venous, fetal hepatic, and ductus venosus blood flow in growth-restricted human fetuses. Am J Obstet Gynecol 190: 1347-1358, 2004.
5. Block BS, Schlafer DH, Wentworth RA, Kreitzer LA, Nathanielsz PW. Intrauterine asphyxia and the breakdown of physiologic circulatory compensation in fetal sheep. Am J Obstet Gynecol 162: 1325-1331, 1990.
6. Brett CM, Teitel DF, Heymann MA, Rudolph AM. The young lamb can increase cardiovascular performance during isoflurane anesthesia. Anesthesiology 71: 751-756, 1989.
7. Cohn HE, Sacks EJ, Heymann MA, Rudolph AM. Cardiovascular responses to hypoxemia and acidemia in fetal lambs. Am J Obstet Gynecol 120: 817-824, 1974.
8. De Muylder X, Fouron JC, Bard H, Urfer FN. Changes in the systolic time intervals of the fetal heart after surgical manipulation of the fetus. Am J Obstet Gynecol 147: 285-288, 1983.
9. Erkinaro T, Mäkikallio K, Kavasmaa T, Alahuhta S, Räsänen J. Effects of ephedrine and phenylephrine on uterine and placental circulations and fetal outcome following fetal hypoxaemia and epidural-induced hypotension in a sheep model. Br J Anaesth 93: 825-832, 2004.
10. Gunnarsson GO, Gudmundsson S, Hokegard K, Stale H, Kjellmer I, Hafstrom O, Marsal K. Cerebral Doppler blood flow velocimetry and central hemodynamics in the ovine fetus during hypoxemia-acidemia. J Perinat Med 26: 107-114, 1998.
11. Hecher K, Campbell S, Doyle P, Harrington K, Nicolaides K. Assessment of fetal compromise by Doppler ultrasound investigation of the fetal circulation. Arterial, intracardiac, and venous blood flow velocity studies. Circulation 91: 129-138, 1995.
12. Hecher K, Snijders R, Campbell S, Nicolaides K. Fetal venous, intracardiac, and arterial blood flow measurements in intrauterine growth retardation: relationship with fetal blood gases. Am J Obstet Gynecol 173: 10-15, 1995.
13. Kiserud T, Jauniaux E, West D, Ozturk O, Hanson MA. Circulatory responses to maternal hyperoxaemia and hypoxaemia assessed non-invasively in fetal sheep at 0.3-05 gestation in acute experiments. BJOG 108: 359-364, 2001.
14. Kiserud T, Ozaki T, Nishina H, Rodeck C, Hanson MA. Effect of NO, phenylephrine, and hypoxemia on ductus venosus diameter in fetal sheep. Am J Physiol Heart Circ Physiol 279: H1166-H1171, 2000.
15. Kiserud T, Rasmussen S, Skulstad S. Blood flow and the degree of shunting through the ductus venosus in the human fetus. Am J Obstet Gynecol 182: 147-153, 2000.
16. Mäkikallio K, Erkinaro T, Niemi N, Kavasmaa T, Acharya G, Pakkila M, Räsänen J. Fetal oxygenation and Doppler ultrasonography of cardiovascular hemodynamics in a chronic near-term sheep model. Am J Obstet Gynecol 194: 542-550, 2006.
17. Mäkikallio K, Vuolteenaho O, Jouppila P, Räsänen J. Ultrasonographic and biochemical markers of human fetal cardiac dysfunction in placental insufficiency. Circulation 105: 2058-2063, 2002.
18. Räsänen J, Wood DC, Debbs RH, Cohen J, Weiner S, Huhta JC. Reactivity of the human fetal pulmonary circulation to maternal hyperoxygenation increases during the second half of pregnancy: a randomized study. Circulation 97: 257-262, 1998.
19. Räsänen J, Wood DC, Weiner S, Ludomirski A, Huhta JC. Role of the pulmonary circulation in the distribution of human fetal cardiac output during the second half of pregnancy. Circulation 94: 1068-1073, 1996.
20. Reuss ML, Rudolph AM. Distribution and recirculation of umbilical and systemic venous blood flow in fetal lambs during hypoxia. J Dev Physiol 2: 71-84, 1980.
21. Schmidt KG, Di Tommaso M, Silverman NH, Rudolph AM. Doppler echocardiographic assessment of fetal descending aortic and umbilical blood flows. Validation studies in fetal lambs. Circulation 83: 1731-1737, 1991.
22. Tchirikov M, Eisermann K, Rybakowski C, Schroder HJ. Doppler ultrasound evaluation of ductus venosus blood flow during acute hypoxemia in fetal lambs. Ultrasound Obstet Gynecol 11: 426-431, 1998.