Long-term ofloxacin testicular toxicity: An experimental study

Andrologia

Volumn 42, Issue 2, 2010, Pages 92-96

  El Harouny, M A ^a   Zalata, A A ^a   Naser, M E ^a   Abo El Atta, H M ^a   El Shawaf, I M ^a   Mostafa, T ^b  

^a MANSOURA UNIVERSITY   (Egypt)

^b CAIRO UNIVERSITY   (Egypt)

Author keywords

Epididymis; Male infertility; Ofloxaxin; Quinolones; Testosterone

Indexed keywords

OFLOXACIN; TESTOSTERONE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD SALVAGE; BODY WEIGHT; CELL HYPERPLASIA; CELL STRUCTURE; CONTROLLED STUDY; DRUG MEGADOSE; EPIDIDYMIS; EXPERIMENTAL STUDY; FOLLOW UP; HISTOPATHOLOGY; LEYDIG CELL; LOW DRUG DOSE; MALE; NONHUMAN; RAT; SPERM; SPERMATOGENESIS; SPERMATOZOON COUNT; SPERMATOZOON MOTILITY; TESTICULAR TOXICITY; TESTIS; TESTIS DISEASE; TESTIS WEIGHT; TESTOSTERONE BLOOD LEVEL; TOXICITY;

ANIMALS; BODY WEIGHT; EPIDIDYMIS; MALE; OFLOXACIN; ORGAN SIZE; RATS; SPERMATOGENESIS; TESTIS;

EID: 77949695308     PISSN: 03034569     EISSN: 14390272     Source Type: Journal    
DOI: 10.1111/j.1439-0272.2009.00961.x     Document Type: Article

References (21)

1. Abd-Allah AR, Aly HA, Moustafa AM, Abdel-Aziz AA, Hamada FM (2000a) Adverse testicular effects of some quinolone members in rats. Pharmacol Res 41 : 211 219.
2. Abd-Allah AR, Gannam BB, Hamada FM (2000b) The impact of ofloxacin on rat testicular DNA: application of image analysis. Pharmacol Res 42 : 145 150.
3. Chambers HF (2001) Sulfonamides, trimethoprim and quinolones. In : Basic and Clinical Pharmacology. Katzung BG (ed 8th edn. McGraw-Hill, NY, USA, pp 793 802.
4. Clegg ED, Perreault SD, Klinefelter GR (2000) Assessment of male reproductive toxicity. In : Principles and Methods of Toxicology. Hayes AW (ed 4th edn., Taylor & Frances, Boston, MA, USA, pp 1263 1300.
5. Cremades A, Ruzafa C, Monserrat F, López-Contreras AJ, Peñafiel R (2004) Influence of dietary arginine on the anabolic effects of androgens. J Endocrinol 183 : 343 351.
6. Crotty KL, May R, Kulvicki A, Kumar D, Neal DE Jr. (1995) The effect of antimicrobial therapy on testicular aspirate flow cytometry. J Urol 153 : 835 838.
7. D'Souza UJ (2003) Tamoxifen induced multinucleated cells (symplasts) and distortion of seminiferous tubules in rat testis. Asian J Androl 5 : 217 220.
8. Drury RAB, Wallington EA (1980) Carelton's Histological Technique, 5th edn. Oxford University Press, London, UK, pp 199 220.
9. Erhart B, Chan PJ, Patton WC, King A (1998) Ofloxacin: the next generation of antibiotic in sperm and embryo cultures for assisted reproductive technologies. Fertil Steril 69 : 246 251.
10. Hinting A, Comhaire F, Schoonjans F (1988) Capacity of objectively assessed sperm motility characteristics in differentiating between semen of fertile and subfertile men. Fertil Steril 50 : 635 639.
11. Khaki A, Novin MG, Khaki AA, Nouri M, Sanati E, Nikmanesh M (2008) Comparative study of the effects of gentamicin, neomycin, streptomycin and ofloxacin antibiotics on sperm parameters and testis apoptosis in rats. Pak J Biol Sci 11 : 1683 1689.
12. Martínez LJ, Sik RH, Chignell CF (1998) Fluoroquinolone antimicrobials: singlet oxygen, superoxide and phototoxicity. Photochem Photobiol 67 : 399 403.
13. Merker HJ, Günther T, Höllriegl V, Vormann J, Schümann K (1996) Lipid peroxidation and morphology of rat testis in magnesium deficiency. Andrologia 28 : 43 51.
14. Ndovi TT, Choi L, Caffo B, Parsons T, Baker S, Zhao M, Rohde C, Hendrix CW (2006) Quantitative assessment of seminal vesicle and prostate drug concentrations by use of a noninvasive method. Clin Pharmacol Ther 80 : 146 158.
15. Onrust SV, Lamb HM, Balfour JA (1998) Ofloxacin. A reappraisal of its use in the management of genitourinary tract infections. Drugs 56 : 895 928.
16. Paget GE, Barnes JM (1964) Toxicity tests. In : Evaluation of Drug Activities: Pharmacometrics. Laurence DR, Bacharach AL (eds). Academic Press, New York, USA, pp 161.
17. Petri WA (2001) Antimicrobial agents: Sulphonamides, trimethoprim- sulfamethoxazole, quinolones and agents for urinary tract infections. In : The Pharmacological Basis of Therapeutics. Hardman JG, Limbird LE, Gilman AG (eds 10th edn. McGraw-Hill, NY, pp 1171 1188.
18. Pichini S, Zuccaro P, Pacifici R (1994) Drugs in semen. Clin Pharmacokinet 26 : 356 373.
19. Sinha RB, Banerjee P, Ganguly AK (2006) Serum concentration of testosterone, epididymal mast cell population and histamine content in relation to sperm count and their motility in albino rats following H2 receptor blocker treatment. Nepal Med Coll J 8 : 36 39.
20. Stahlmann R (2002) Clinical toxicological aspects of fluoroquinolones. Toxicol Lett 127 : 269 277.
21. Stahlmann R, Lode H (1999) Toxicity of quinolones. Drugs 58 (Suppl 2 37 42.