Is human papillomavirus viral load a clinically useful predictive marker? A longitudinal study

Cancer Epidemiology Biomarkers and Prevention

Volumn 19, Issue 3, 2010, Pages 832-837

  Constandinou Williams, Christothea ^a   Collins, Stuart I ^a   Roberts, Sally ^a   Young, Lawrence S ^a   Woodman, Ciaran B J ^a   Murray, Paul G ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADOLESCENT; ADULT; ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN PAPILLOMAVIRUS TYPE 16; HUMAN PAPILLOMAVIRUS TYPE 18; MAJOR CLINICAL STUDY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; VIRUS INFECTION; VIRUS LOAD;

ADOLESCENT; DNA, VIRAL; FEMALE; GENE DOSAGE; HUMAN PAPILLOMAVIRUS 16; HUMAN PAPILLOMAVIRUS 18; HUMANS; LONGITUDINAL STUDIES; PAPILLOMAVIRUS INFECTIONS; POLYMERASE CHAIN REACTION; RISK FACTORS; TUMOR MARKERS, BIOLOGICAL; UTERINE CERVICAL NEOPLASMS; VIRAL LOAD; YOUNG ADULT;

EID: 77949693551     PISSN: 10559965     EISSN: None     Source Type: Journal    
DOI: 10.1158/1055-9965.EPI-09-0838     Document Type: Article

References (14)

1. Hesselink AT, Berkhof J, Heideman DA, et al. High-risk human papillomavirus DNA load in a population-based cervical screening cohort in relation to the detection of high-grade cervical intraepithelial neoplasia and cervical cancer. Int J Cancer 2009;124:381.
2. Woodman CB, Collins SI, Young LS. The natural history of cervical HPV infection: unresolved issues. Nat Rev Cancer 2007;7: 11-22.
3. Gravitt PE, Kovacic MB, Herrero R, et al. High load for most high risk human papillomavirus genotypes is associated with prevalent cervical cancer precursors but only HPV16 load predicts the development of incident disease. Int J Cancer 2007;121:2787-93.
4. Xi LF, Kiviat NB, Galloway DA, Zhou XH, Ho J, Koutsky LA. Effect of cervical cytologic status on the association between human papillomavirus type 16 DNA load and the risk of cervical intraepithelial neoplasia grade 3. Infect Dis 2008;198:324-31.
5. Xi LF, Koutsky LA, Castle PE, et al. Human papillomavirus type 18 DNA load and 2-year cumulative diagnoses of cervical intraepithelial neoplasia grades 2-3. J Natl Cancer Inst 2009;101:153-61.
6. Woodman CB, Collins S, Winter H, et al. Natural history of cervical human papillomavirus infection in young women: a longitudinal cohort study. Lancet 2001;357:1831-6.
7. Collins SI, Constandinou-Williams C, Wen K, et al. Disruption of the E2 gene is a common and early event in the natural history of cervical human papillomavirus infection: a longitudinal cohort study. Cancer Res 2009;69:3828-32.
8. Smith PJ, Thompson TJ, Jereb JA. A model for interval-censored tuberculosis outbreak data. Stat Med 1997;16:485-96.
9. Ho CM, Cheng WF, Chu TY, et al. Human papillomaviral load changes in low-grade squamous intraepithelial lesions of the uterine cervix. Br J Cancer 2006;95:1384-9.
10. Franco EL, Coutlée F. Prognostic value of measuring load of human papillomavirus DNA in cervical samples: an elusive target. J Natl Cancer Inst 2009;101:131-3.
11. Depuydt CE, Benoy IH, Bailleul EJ, Vandepitte J, Vereecken AJ, Bogers JJ. Improved endocervical sampling and HPV viral load detection by Cervex-Brush Combi. Cytopathology 2006;17:374-81.
12. Sherman ME, Wang SS, Wheeler CM, et al. Determinants of human papillomavirus load among women with histological cervical intraepithelial neoplasia 3: dominant impact of surrounding low-grade lesions. Cancer Epidemiol Biomarkers Prev 2003;12:1038-44.
13. Van Tine BA, Kappes JC, Banerjee NS, Chow LT, et al. Clonal selection for transcriptionally active viral oncogenes during progression to cancer. J Virol 2004;78:11172-86.
14. Winer RL, Harris TG, Xi LF, et al. Quantitative human papillomavirus 16 and 18 levels in incident infections and cervical lesion development. J Med Virol 2009;81:713-21.