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Volumn 7, Issue 2, 2010, Pages 143-161

Molecular diagnostics and personalized medicine: value-assessed opportunities for multiple stakeholders

Author keywords

Biologicals; Companion diagnostics; Drugs; Pharmaceuticals; Pharmacogenetics; Prediction; Prevention; Value assessment

Indexed keywords

ABACAVIR; CETUXIMAB; ENTECORT; GEFITINIB; MARAVIROC; PANITUMUMAB; UNCLASSIFIED DRUG;

EID: 77949670386     PISSN: 17410541     EISSN: 1744828X     Source Type: Journal    
DOI: 10.2217/pme.10.1     Document Type: Review
Times cited : (20)

References (27)
  • 3
    • 64049096916 scopus 로고    scopus 로고
    • The microeconomics of personalised medicine: Today's challenge and tomorrow's promise
    • Davis JC, Furstenthal L, Desai AA et al.: The microeconomics of personalised medicine: today's challenge and tomorrow's promise. Nat. Rev. Drug Discov. 8(4), 279-286 (2009).
    • (2009) Nat. Rev. Drug Discov. , vol.8 , Issue.4 , pp. 279-286
    • Davis, J.C.1    Furstenthal, L.2    Desai, A.A.3
  • 4
    • 0033606540 scopus 로고    scopus 로고
    • Drug resistance genotyping in HIV-1 therapy: The VIRADAPT randomised controlled trial
    • Durant J, Clevenbergh P, Halfon P et al.: Drug resistance genotyping in HIV-1 therapy: the VIRADAPT randomised controlled trial. Lancet 353(9171), 2195-2199 (1999).
    • (1999) Lancet , vol.353 , Issue.9171 , pp. 2195-2199
    • Durant, J.1    Clevenbergh, P.2    Halfon, P.3
  • 6
    • 64149105211 scopus 로고    scopus 로고
    • Utilizing the molecular gateway: The path to personalized cancer management
    • Overdevest JB, Theodorescu D, Lee JK: Utilizing the molecular gateway: the path to personalized cancer management. Clin. Chem. 55(4), 684-697 (2009).
    • (2009) Clin. Chem. , vol.55 , Issue.4 , pp. 684-697
    • Overdevest, J.B.1    Theodorescu, D.2    Lee, J.K.3
  • 7
    • 33847384406 scopus 로고    scopus 로고
    • The effects of business practices, licensing, and intellectual property on development and dissemination of the polymerase chain reaction
    • Fore J, Wiechers IR, Cook-Deegan R: The effects of business practices, licensing, and intellectual property on development and dissemination of the polymerase chain reaction. J. Biomed. Discov. Collab. 1, 7 (2006)
    • (2006) J. Biomed. Discov. Collab. , vol.1 , pp. 7
    • Fore, J.1    Wiechers, I.R.2    Cook-Deegan, R.3
  • 8
    • 58149186582 scopus 로고    scopus 로고
    • Do molecularly targeted agents in oncology have reduced attrition rates?
    • Walker I, Newell H: Do molecularly targeted agents in oncology have reduced attrition rates? Nat. Rev. Drug Discov. 8, 15-16 (2009).
    • (2009) Nat. Rev. Drug Discov. , vol.8 , pp. 15-16
    • Walker, I.1    Newell, H.2
  • 10
    • 52449133413 scopus 로고    scopus 로고
    • Assessing the value-adding impact of diagnostic-type tests on drug development and marketing
    • Blair ED: Assessing the value-adding impact of diagnostic-type tests on drug development and marketing. Mol. Diagn. Ther. 12(5), 331-337 (2008).
    • (2008) Mol. Diagn. Ther. , vol.12 , Issue.5 , pp. 331-337
    • Blair, E.D.1
  • 11
    • 77949700354 scopus 로고    scopus 로고
    • Why you should care about the innovative medicines initiative
    • Blair ED: Why you should care about the innovative medicines initiative. CR Focus 12(7), 14-20 (2008).
    • (2008) CR Focus , vol.12 , Issue.7 , pp. 14-20
    • Blair, E.D.1
  • 12
    • 33751581755 scopus 로고    scopus 로고
    • Pipeline problems are increasing the urge to merge
    • Franz S: Pipeline problems are increasing the urge to merge. Nat. Rev. Drug Discov. 5, 977-979 (2006).
    • (2006) Nat. Rev. Drug Discov. , vol.5 , pp. 977-979
    • Franz, S.1
  • 13
    • 33947712686 scopus 로고    scopus 로고
    • Stratified medicine: Strategic and economic implications of combining drugs and clinical biomarkers
    • Trusheim MR, Berndt ER, Douglas FL: Stratified medicine: strategic and economic implications of combining drugs and clinical biomarkers. Nat. Rev. Drug Discov. 6, 287-293 (2007).
    • (2007) Nat. Rev. Drug Discov. , vol.6 , pp. 287-293
    • Trusheim, M.R.1    Berndt, E.R.2    Douglas, F.L.3
  • 14
    • 65249182067 scopus 로고    scopus 로고
    • The comparative effectiveness challenge
    • Hughes B: The comparative effectiveness challenge. Nat. Rev. Drug Discov. 8, 261-263 (2009).
    • (2009) Nat. Rev. Drug Discov. , vol.8 , pp. 261-263
    • Hughes, B.1
  • 15
    • 34249028688 scopus 로고    scopus 로고
    • Personalized medicine: Elusive dream or imminent reality?
    • Lesko L: Personalized medicine: elusive dream or imminent reality? Clin. Pharmacol. Ther. 81(6), 807-816 (2007).
    • (2007) Clin. Pharmacol. Ther. , vol.81 , Issue.6 , pp. 807-816
    • Lesko, L.1
  • 16
    • 36749080921 scopus 로고    scopus 로고
    • Novel risk-sharing scheme puts the spotlight on biomarkers
    • Hughes B: Novel risk-sharing scheme puts the spotlight on biomarkers. Nat. Rev. Drug Discov. 6, 945 (2007).
    • (2007) Nat. Rev. Drug Discov. , vol.6 , pp. 945
    • Hughes, B.1
  • 17
    • 70449631602 scopus 로고    scopus 로고
    • Paying for outcomes: Innovative coverage and reimbursement schemes for pharmaceuticals
    • Carlson JJ, Garrison LP, Sullivan SD: Paying for outcomes: innovative coverage and reimbursement schemes for pharmaceuticals. J. Manag. Care Pharm. 15, 683-687 (2009).
    • (2009) J. Manag. Care Pharm. , vol.15 , pp. 683-687
    • Carlson, J.J.1    Garrison, L.P.2    Sullivan, S.D.3
  • 19
    • 70350629002 scopus 로고    scopus 로고
    • Predictive tests and personalised medicines
    • 21st October
    • Blair ED: Predictive tests and personalised medicines. Drug Discovery World, 21st October (2009).
    • (2009) Drug Discovery World
    • Blair, E.D.1
  • 20
    • 52149112915 scopus 로고    scopus 로고
    • Pharmacogenetics of hypersensitivity to abacavir: From PGx hypothesis to confirmation to clinical utility
    • Hughes AR, Spreen WR, Mosteller M et al.: Pharmacogenetics of hypersensitivity to abacavir: from PGx hypothesis to confirmation to clinical utility. Pharmacogenomics J. 8, 365-374 (2008).
    • (2008) Pharmacogenomics J. , vol.8 , pp. 365-374
    • Hughes, A.R.1    Spreen, W.R.2    Mosteller, M.3
  • 22
    • 33947196825 scopus 로고    scopus 로고
    • Impact of a 21-gene RT-PCR assay on treatment decisions in early-stage breast cancer - An economic analysis based on prognostic and predictive validation studies
    • Lyman GH, Cosler LE, Kuderer NM, Hornberger J: Impact of a 21-gene RT-PCR assay on treatment decisions in early-stage breast cancer - an economic analysis based on prognostic and predictive validation studies. Cancer 109(6), 1011-1018 (2007).
    • (2007) Cancer , vol.109 , Issue.6 , pp. 1011-1018
    • Lyman, G.H.1    Cosler, L.E.2    Kuderer, N.M.3    Hornberger, J.4
  • 23
    • 33747400905 scopus 로고    scopus 로고
    • Frequency and cost of chemotherapy-related serious adverse effects in a population sample of women with breast cancer
    • Hassett MJ, O'Malley AJ, Pakes JR, Newhouse JP, Earle CC: Frequency and cost of chemotherapy-related serious adverse effects in a population sample of women with breast cancer. J. Natl Cancer Inst. 98(16), 1108-1117 (2006).
    • (2006) J. Natl Cancer Inst. , vol.98 , Issue.16 , pp. 1108-1117
    • Hassett, M.J.1    O'Malley, A.J.2    Pakes, J.R.3    Newhouse, J.P.4    Earle, C.C.5
  • 24
    • 77949741920 scopus 로고    scopus 로고
    • Gazing into the future
    • Levine DS: Gazing into the future. J. Life Sciences 3, 18-25 (2009)
    • (2009) J. Life Sciences , vol.3 , pp. 18-25
    • Levine, D.S.1
  • 25
    • 35948952077 scopus 로고    scopus 로고
    • Realizing the promise of personalized medicine
    • 165
    • Aspinall MG, Hamermesh RG: Realizing the promise of personalized medicine. Harv. Bus. Rev. 85(10), 108-117, 165 (2007)
    • (2007) Harv. Bus. Rev. , vol.85 , Issue.10 , pp. 108-117
    • Aspinall, M.G.1    Hamermesh, R.G.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.