Toxic tacrolimus blood levels with rifampin administration in a renal transplant recipient

Annals of Transplantation

Volumn 15, Issue 1, 2010, Pages 57-60

  Halim, Mehat Abdel ^a   Al Otaibi, Torki ^a   Gheith, Osama ^a   El Kholy, Osama ^a   Tawab, Khaled Abdel ^a   Said, Tarek ^a   Nair, Prasad ^a   Nampoory, M R N ^a  

^a IBN SINA HOSPITAL   (Kuwait)

Author keywords

Antibiotic rifampicin; Enzyme induction Drug effects; Graft function; Tacrolimus Pharmacokinetics

Indexed keywords

ANTACID AGENT; AZATHIOPRINE; CREATININE; CYCLOSPORIN; CYTOCHROME P450 3A4; ETHAMBUTOL; GLYCOPROTEIN P; ISONIAZID; LOPERAMIDE; METOCLOPRAMIDE; OMEPRAZOLE; ONDANSETRON; PARACETAMOL; PREDNISOLONE; PYRAZINAMIDE; RAPAMYCIN; RIFAMPICIN; TACROLIMUS; TUBERCULIN;

ADULT; ARTICLE; CASE REPORT; CHEMOPROPHYLAXIS; CHRONIC DIARRHEA; CHRONIC GRAFT REJECTION; CHRONIC KIDNEY DISEASE; COMPUTER ASSISTED TOMOGRAPHY; CREATININE BLOOD LEVEL; DISEASE ASSOCIATION; DISEASE EXACERBATION; DRUG BLOOD LEVEL; DRUG DOSE REDUCTION; DRUG EFFECT; DRUG POTENTIATION; DRUG SUBSTITUTION; DRUG WITHDRAWAL; ENZYME INHIBITION; FEMALE; GASTRITIS; GASTROINTESTINAL BIOPSY; GINGIVA HYPERPLASIA; GRAFT RECIPIENT; HUMAN; HUMAN TISSUE; IMMUNOSUPPRESSIVE TREATMENT; IRON DEFICIENCY ANEMIA; KIDNEY FUNCTION; KIDNEY GRAFT; KIDNEY GRAFT REJECTION; KIDNEY TRANSPLANTATION; LOW DRUG DOSE; LYMPHADENOPATHY; MAINTENANCE THERAPY; PYREXIA IDIOPATHICA; TREATMENT OUTCOME; TUBERCULOSIS;

ADULT; AZATHIOPRINE; CREATININE; CYTOCHROME P-450 CYP3A; DIARRHEA; FEMALE; HUMANS; INTESTINES; KIDNEY FUNCTION TESTS; KIDNEY TRANSPLANTATION; LIVER; OMEPRAZOLE; P-GLYCOPROTEIN; RIFAMPIN; SIROLIMUS; TACROLIMUS;

EID: 77949669893     PISSN: 14259524     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (11)

1. Hebert MF, Fisher RM, Marsh CL et al: Effects of rifampin on tacrolimus pharmacokinetics in healthy volunteers.J Clin Pharmacol, 1999; 39(1): 91-96
2. Bhaloo S, Prasad GV: Severe reduction in tacrolimus levels with rifampin despite multiple cytochrome P450 inhibitors: a case report. Transplant Proc, 2003; 35(7): 2449-51
3. Lemahieu W, Maes B, Verbeke K et al: Cytochrome P450 3A4 and P-glycoprotein Activity and Assimilation of Tacrolimus in Transplant Patients with Persistent Diarrhea. Am J Transplant, 2005; 5(6): 1383-91
4. Pascual J, Marcén R, Orea OF. et al: Interaction between omeprazole and tacrolimus in renal allograft recipients: a clinical-analytical studv. Transplant Proc, 2005; 37(9): 3752-53
5. Prescott WA Jr, Callahan BL, Park JM: Tacrolimus toxicity associated with concomitant metoclopramide therapy. Pharmacotherapy, 2004; 24(4): 532-37
6. Weblinks: http://www.pdrhealth.com/drugs/drugs-index.aspx and http://www.drugs.com/drug-information.html. Accessed 2008 Aug 5
7. Chisholm MA, Mulloy LL, Jagadeesan M, DiPiro JT: Coadministration of tacrolimus with anti-acid drugs. Transplantation, 2003; 76(4): 665-66
8. Peloquin CA, Namdar R, Singleton MD, Nix DE: Pharmacokinetics of rifampin under fasting conditions, with food, and with antacids. Chest, 1999; 115(1): 12-18
9. Plosker GL, Foster RH: Tacrolimus: a further update of its pharmacology and therapeutic use in the management of organ transplantation. Drugs, 2000; 59: 323-89
10. Naranjo CA, Busto U. Sellers EM el al: A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther, 1981; 30: 239-45
11. Lemahieu WP, Maes BD, Verbeke K, Vanrenterghem Y: CYP3A4 and P-glycoprotein activity in healthy controls and transplant patients on cyclosporin vs. tacrolimus vs. sirolimus. Am J Transplant, 2004; 4(9): 1514-22