Augmented peripheral chemoreflex in patients with heart failure and inspiratory muscle weakness

Respiratory Physiology and Neurobiology

Volumn 171, Issue 1, 2010, Pages 31-35

  Callegaro, Carine C ^a   Martinez, Denis ^a,b   Ribeiro, Paula A B ^a   Brod, Marta ^a   Ribeiro, Jorge P ^a,b  

^a HOSPITAL DE CLÍNICAS DE PORTO ALEGRE   (Brazil)

^b FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

Exercise oscillatory ventilation; Inspiratory muscle training; Single breath CO2 test

Indexed keywords

ADULT; ARTICLE; BREATH ANALYSIS; CARBON DIOXIDE BREATHING; CARDIOPULMONARY EXERCISE TEST; CHEMORECEPTOR REFLEX; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HEART FAILURE; HUMAN; INSPIRATORY MUSCLE WEAKNESS; LUNG PRESSURE; LUNG VENTILATION; MALE; MUSCLE STRENGTH; MUSCLE WEAKNESS; PRIORITY JOURNAL;

ADULT; CARBON DIOXIDE; CHEMORECEPTOR CELLS; EXERCISE TEST; FEMALE; HUMANS; INTERMITTENT POSITIVE-PRESSURE VENTILATION; MALE; MIDDLE AGED; MUSCLE STRENGTH; MUSCLE WEAKNESS; MUSCLE, SKELETAL; PREDICTIVE VALUE OF TESTS; PULMONARY VENTILATION; VENTRICULAR DYSFUNCTION, LEFT;

EID: 77949658102     PISSN: 15699048     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.resp.2010.01.009     Document Type: Article

References (28)

1. Agostoni P., Apostolo A., and Albert R.K. Mechanisms of periodic breathing during exercise in patients with chronic heart failure. Chest 133 (2008) 197-203
2. Arena R., Pinkstaff S., Wheeler E., Peberdy M.A., Guazzi M., and Myers J. Neuromuscular electrical stimulation and inspiratory muscle training as potential adjunctive rehabilitation options for patients with heart failure. Journal of Cardiopulmonary Rehabilitation and Prevention (2009) December (Epub ahead of print)
3. American Thoracic Society/European Respiratory Society. Statement on respiratory muscle testing. American Journal of Respiratory and Critical Care Medicine 166 (2002) 518-624
4. Chiappa G.R., Roseguini B.T., Vieira P.J., Alves C.N., Tavares A., Winkelmann E.R., Ferlin E.L., Stein R., and Ribeiro J.P. Inspiratory muscle training improves blood flow to resting and exercising limbs in patients with chronic heart failure. Journal of the American College of Cardiology 51 (2008) 1663-1671
5. Chua T.P., Clark A.L., Amadi A.A., and Coats A.J. Relation between chemosensitivity and the ventilatory response to exercise in chronic heart failure. Journal of the American College of Cardiology 27 (1996) 650-657
6. Chua T.P., Ponikowski P., Webb-Peploe K., Harrington D., Anker S.D., Piepoli M., and Coats A.J. Clinical characteristics of chronic heart failure patients with an augmented peripheral chemoreflex. European Heart Journal 18 (1997) 480-486
7. Dall'Ago P., Chiappa G.R., Guths H., Stein R., and Ribeiro J.P. Inspiratory muscle training in patients with heart failure and inspiratory muscle weakness: a randomized trial. Journal of the American College of Cardiology 47 (2006) 757-763
8. Di Vanna A., Braga A.M., Laterza M.C., Ueno L.M., Rondon M.U., Barretto A.C., Middlekauff H.R., and Negrão C.E. Blunted muscle vasodilatation during chemoreceptor stimulation in patients with heart failure. American Journal of Physiology, Heart and Circulatory Physiology 293 (2007) H846-H852
9. Francis D.P., Davis L.C., Piepoli M., Rauchhaus, Ponikowiski P., and Coats A.J.S. Origin of oscillatory kinetics of respiratory gas exchange in chronic heart failure. Circulation 100 (1999) 1065-1070
10. Frankenstein L., Meyer F.J., Sigg C., Nelles M., Schellberg D., Remppis A., Katus H.A., and Zugck C. Is serial determination of inspiratory muscle strength a useful prognostic marker in chronic heart failure?. European Journal of Cardiovascular Prevention and Rehabilitation 15 (2008) 156-161
11. Giannoni A., Emdin M., Bramanti F., Iudici G., Francis D.P., Barsotti A., Piepoli M., and Passino C. Combined increased chemosensitivity to hypoxia and hypercapnea as a prognosticator in heart failure. Journal of the American College of Cardiology 53 (2009) 1975-1980
12. 2 response during sleep and wakefulness in healthy men. Respiratory Physiology & Neurobiology 162 (2008) 138-143
13. 2 as a clinical test of the peripheral chemoreflex. Journal of Applied Physiology 64 (1988) 84-89
14. Mello P., Gerra G., Dall'Ago P., Borille S., Rondom M.U., Negrao C.E., Mostarda C., Irigoyen M.C., Krieger E.M., and Consolim-Colombo F. Inspiratory muscle training decreases central and peripheral sympathetic activity and improves reflex vasodilatory responses in patients with chronic heart failure. Circulation 118 (2008) S719 (abstract)
15. Meyer T., Georg T., Becker C., and Kindermann W. Reliability of gas exchange measurement from two different spiroergometry systems. International Journal of Sports Medicine 22 (2001) 593-597
16. Neder J.A., Andreoni S., Lerario M.C., and Nery L.E. Reference values for lung function tests. II. Maximal respiratory pressures and voluntary ventilation. Brazilian Journal of Medical and Biological Research 32 (1999) 719-727
17. Piepoli M.F., Ponikowski P.P., Volterrani M., Francis D., and Coats A.J. Aetiology and pathophysiological implications of oscillatory ventilation at rest and during exercise in chronic heart failure. Do Cheyne and Stokes have an important message for modern-day patients with heart failure?. European Heart Journal 20 (1999) 946-953
18. Ponikowski P., Anker S.D., Chua T.P., Francis D., Banasiak W., Poole-Wilson P.A., Coats A.J., and Piepoli M. Oscillatory breathing patterns during wakefulness in patients with chronic heart failure: clinical implications and role of augmented peripheral chemosensitivity. Circulation 100 (1999) 2418-2424
19. Ponikowski P., Chua T.P., Anker S.D., Francis D.P., Doehner W., Banasiak W., Poole-Wilson P.A., Piepoli M.F., and Coats A.J. Peripheral chemoreceptor hypersensitivity: an ominous sign in patients with chronic heart failure. Circulation 104 (2001) 544-549
20. Ponikowski P., Francis D.P., Piepoli M.F., Davies L.C., Chua T.P., Davos C.H., Florea V., Banasiak W., Poole-Wilson P.A., Coats A.J., and Anker S.D. Enhanced ventilatory response to exercise in patients with chronic heart failure and preserved exercise tolerance marker of abnormal cardiorespiratory reflex control and predictor of poor prognosis. Circulation 103 (2001) 967-972
21. Ponikowski P.P., Chua T.P., Francis D.P., Capucci A., Coats A.J., and Piepoli M.F. Muscle ergoreceptor overactivity reflects deterioration in clinical status and cardiorespiratory reflex control in chronic heart failure. Circulation 104 (2001) 2324-2330
22. Ribeiro J.P. Periodic breathing in heart failure. Bridging the gap between the sleep laboratory and the exercise laboratory. Circulation 113 (2006) 9-10
23. Ribeiro J.P., Stein R., and Chiappa G.R. Beyond peak oxygen uptake. New prognostic markers from gas exchange exercise tests in chronic heart failure. Journal of Cardiopulmonary Rehabilitation 26 (2006) 63-71
24. Ribeiro J.P., Chiappa G.R., Neder J.A., and Frankenstein L. Respiratory muscle function and exercise intolerance in heart failure. Current Heart Failure Reports 6 (2009) 95-101
25. St Croix C.M., Morgan B.J., Wetter T.J., and Dempsey J.A. Fatiguing inspiratory muscle work causes reflex sympathetic activation in humans. Journal of Physiology 529 (2000) 493-504
26. Stein R., Chiappa G.R., Güths H., Dall'Ago P., and Ribeiro J.P. Inspiratory muscle training improves oxygen uptake efficiency slope in patients with chronic heart failure. Journal of Cardiopulmonary Rehabilitation and Prevention 29 (2009) 392-395
27. Tumminello G., Guazzi M., Lancellotti P., and Piérard L.A. Exercise ventilation inefficiency in heart failure: pathophysiological and clinical significance. European Heart Journal 28 (2007) 673-678
28. Winkelmann E.R., Chiappa G.R., Lima C.O.C., Viecili P.R.N., Stein R., and Ribeiro J.P. Addition of inspiratory muscle training to aerobic training improves cardiorespiratory responses to exercise in patients with heart failure and inspiratory muscle weakness. American Heart Journal 158 (2009) 768e1-768e7