PKC-delta induces cardiomyogenic gene expression in human adipose-derived stem cells

Biochemical and Biophysical Research Communications

Volumn 393, Issue 4, 2010, Pages 582-586

  Park, Eulsoon ^a   Patel, Amit N ^b  

^a University of Pittsburgh   (United States)

^b UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

Adipose derived stem cells; Cardiogenic differentiation; PKC delta

Indexed keywords

ACTIN; MESSENGER RNA; MUSCLE PROTEIN; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE C DELTA; PROTEIN KINASE C THETA; PROTEIN MEF2C; TROPONIN; UNCLASSIFIED DRUG;

ADIPOSE TISSUE CELL; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; GENE OVEREXPRESSION; HEART MUSCLE CELL; HUMAN; HUMAN CELL; MUSCLE DEVELOPMENT; PRIORITY JOURNAL; STEM CELL;

ADIPOSE TISSUE; CELL DIFFERENTIATION; CELLS, CULTURED; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; MESENCHYMAL STEM CELLS; MYOCYTES, CARDIAC; PROTEIN KINASE C-DELTA; PROTEIN KINASE INHIBITORS; RNA, MESSENGER; TETRADECANOYLPHORBOL ACETATE;

EID: 77949656253     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2010.02.018     Document Type: Article

References (13)

1. Strem B.M., Hicok K.C., Zhu M., Wulur I., Alfonso Z., Schreiber R.E., Fraser J.K., and Hedrick M.H. Multipotential differentiation of adipose tissue-derived stem cells. Keio J. Med. 54 (2005) 132-141
2. Rodriquez L.V., Alfonso Z., Zhang R., Leung J., Wu B., and Ignarro L.J. Clonogenic multipotent stem cells in huma adipose tissue differentiate into functional smooth muscle cells. Proc. Natl. Acad. Sci. USA 103 (2006) 12167-12172
3. Zuk P.A., Zhu M., Ashjian P., De Ugarte D.A., Huang J.I., Mizuno H., Alfonso Z.C., Fraser J.K., Benhaim P., and Hedrick M.H. Human adipose tissue is a source of multipotent stem cells. Mol. Biol. Cell 13 (2002) 4279-4295
4. Srivastava D. Making or breaking the heart: from lineage determination to morphogenesis. Cell 126 (2006) 1037-1048
5. Zhou X., Quann E., and Gallicano G.I. Differentiation of nonbeating embryonic stem cells into beating cardiomyocytes is dependent on downregulation of PKC beta and zeta in concert with upregulation of PKC epsilon. Dev. Biol. 255 (2003) 407-422
6. Puceat M., Hilarl-Dandan R., Strulovici B., Brunton L.L., and Brown J.H. Differential regulation of protein kinase C isoforms in isolated neonatal and adult rat cardiomyocytes. J. Biol. Chem. 269 (1994) 16938-16944
7. Webb P.R., Dovle C., and Anderson N.G. Protein kinase C-epsilon promotes adipogenic commitment and is essential for terminal differentiation of 3T3-F442A preadipocytes. Cell. Mol. Life Sci. 60 (2003) 1504-1512
8. Fleming I., MacKenzie S.F., Vernon R.G., Anderson N.G., Houslay M.D., and Kilqour E. Protein kinase C isoforms play differential roles in the regulation of adipocyte differentiation. Biochem. J. 333 (1998) 719-727
9. Malhotra A., Kang B.P., Opawumi D., Belizaire W., and Meggs L.G. Molecular biology of protein kinase C signaling in cardiac myocytes. Mol. Cell. Biochem. 225 (2001) 97-107
10. Steinberg S.F., Goldberg M., and Rybin V.O. Protein kinase C isoform diversity in the heart. J. Mol. Cell. Cardiol. 27 (1995) 141-153
11. Koyanaqi M., Iwasaki M., Haendeler J., Leitqes M., Zeiher A.M., and Dimmeler S. Wnt5a increases cardiac gene expressions of cultured human circulating progenitor cells via a PKC delta activation. PLoS One 4 (2009) e5765
12. Gobbi G., Mirandola P., Sponzilli I., Micheloni C., Malinverno C., Cocco L., and Vitale M. Timing and expression level of protein kinase C epsilon regulate the megakaryocytic differentiation of human CD34 cells. Stem Cells 25 (2007) 2322-2329
13. Koyanagi M., Haendeler J., Badorff C., Brandes R.P., Hoffmann J., Pandur P., Zeiher A.M., Kühl M., and Dimmeler S. Non-canonical Wnt signaling enhances differentiation of human circulating progenitor cells to cardiomyogenic cells. J. Biol. Chem. 280 (2005) 16838-16842