Th17 cytokines and vaccine-induced immunity

Seminars in Immunopathology

Volumn 32, Issue 1, 2010, Pages 79-90

  Lin, Yinyao ^a   Slight, Samantha R ^a   Khader, Shabaana A ^a,b  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

Author keywords

Infection; Th17; Vaccine induced immunity

Indexed keywords

CYTOKINE; INTERLEUKIN 17; VACCINE;

HUMAN; IMMUNE RESPONSE; IMMUNITY; INFECTION; INNATE IMMUNITY; MYCOSIS; NONHUMAN; PRIORITY JOURNAL; REVIEW; TH17 CELL;

ANIMALS; HUMANS; IMMUNITY, ACTIVE; IMMUNOLOGIC MEMORY; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, HELPER-INDUCER; VACCINATION;

EID: 77949654682     PISSN: 18632297     EISSN: 18632300     Source Type: Journal    
DOI: 10.1007/s00281-009-0191-2     Document Type: Review

References (116)

1. EV Acosta-Rodriguez L Rivino J Geginat D Jarrossay M Gattorno A Lanzavecchia F Sallusto G Napolitani 2007 Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells Nat Immunol 8 639 646 17486092 10.1038/ni1467 1:CAS:528:DC%2BD2sXlsVSrsLo%3D (Pubitemid 46785128)
2. EM Agger JP Cassidy J Brady KS Korsholm C Vingsbo-Lundberg P Anderson 2008 Adjuvant modulation of the cytokine balance in Mycobacterium tuberculosis subunit vaccines; immunity, pathology and protection Immunology 124 175 185 18201185 10.1111/j.1365-2567.2007.02751.x 1:CAS:528:DC%2BD1cXntlWksr0%3D
3. EM Agger I Rosenkrands J Hansen K Brahimi BS Vandahl C Aagaard K Werninghaus C Kirschning R Lang D Christensen M Theisen F Follmann P Andersen 2008 Cationic liposomes formulated with synthetic mycobacterial cordfactor (CAF01): a versatile adjuvant for vaccines with different immunological requirements PLoS ONE 3 e3116 18776936 10.1371/journal.pone.0003116 1:CAS:528:DC%2BD1cXhtFKltrzF
4. AA Akhiani LA Nilsson O Ouchterlony 1997 Intranasal administration of Schistosoma mansoni adult worm antigen in combination with cholera toxin induces a Th2 cell response Parasite Immunol 19 183 190 9149285 10.1046/j.1365-3024. 1997.d01-196.x 1:CAS:528:DyaK2sXkslCnt78%3D
5. P Andersen B Smedegaard 2000 CD4(+) T-cell subsets that mediate immunological memory to Mycobacterium tuberculosis infection in mice Infect Immun 68 621 629 10639425 10.1128/IAI.68.2.621-629.2000 1:CAS:528: DC%2BD3cXotFOmtg%3D%3D (Pubitemid 30056515)
6. R Arens P Wang J Sidney A Loewendorf A Sette SP Schoenberger B Peters CA Benedict 2008 Cutting edge: murine cytomegalovirus induces a polyfunctional CD4 T cell response J Immunol 180 6472 6476 18453564 1:CAS:528:DC%2BD1cXltlCkt7o%3D
7. SJ Aujla YR Chan M Zheng M Fei DJ Askew DA Pociask TA Reinhart F McAllister J Edeal K Gaus S Husain JL Kreindler PJ Dubin JM Pilewski MM Myerburg CA Mason Y Iwakura JK Kolls 2008 IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia Nat Med 14 275 281 18264110 10.1038/nm1710 1:CAS:528:DC%2BD1cXivFOrtLg%3D
8. S Banus RM Stenger ER Gremmer JA Dormans FR Mooi TG Kimman RJ Vandebriel 2008 The role of Toll-like receptor-4 in pertussis vaccine-induced immunity BMC Immunol 9 21 18498620 10.1186/1471-2172-9-21 1:CAS:528:DC%2BD1cXpvF2ksrs%3D
9. M Batten J Li S Yi NM Kljavin DM Danilenko S Lucas J Lee FJ de Sauvage N Ghilardi 2006 Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells Nat Immunol 7 929 936 16906167 10.1038/ni1375 1:CAS:528:DC%2BD28XotlCitbo%3D (Pubitemid 44263906)
10. S Black H Shinefield B Fireman E Lewis P Ray JR Hansen L Elvin KM Ensor J Hackell G Siber F Malinoski D Madore I Chang R Kohberger W Watson R Austrian K Edwards 2000 Efficacy, safety and immunogenicity of heptavalent pneumococcal conjugate vaccine in children. Northern California Kaiser Permanente Vaccine Study Center Group Pediatr Infect Dis J 19 187 195 10749457 10.1097/00006454- 200003000-00003 1:STN:280:DC%2BD3c3htFShug%3D%3D (Pubitemid 30167436)
11. D Bogaert D Weinberger C Thompson M Lipsitch R Malley 2009 Impaired innate and adaptive immunity to Streptococcus pneumoniae and its effect on colonization in an infant mouse model Infect Immun 77 1613 1622 19168741 10.1128/IAI.00871-08 1:CAS:528:DC%2BD1MXjvFanu7c%3D
12. DM Bowdish K Sakamoto MJ Kim M Kroos S Mukhopadhyay CA Leifer K Tryggvason S Gordon DG Russell 2009 MARCO, TLR2, and CD14 are required for macrophage cytokine responses to mycobacterial trehalose dimycolate and Mycobacterium tuberculosis PLoS Pathog 5 e1000474 19521507 10.1371/journal.ppat. 1000474 1:CAS:528:DC%2BD1MXnsFSqsbs%3D
13. CDC (2006) Helicobacter pylori and peptic ulcer disease: the key to a cure. http://www.cdc.gov/ulcer/keytocure.htm
14. Z Chen A Laurence JJ O'Shea 2007 Signal transduction pathways and transcriptional regulation in the control of Th17 differentiation Semin Immunol 19 400 408 18166487 10.1016/j.smim.2007.10.015 1:CAS:528:DC%2BD1cXisVSrsb4%3D
15. Y Chung X Yang SH Chang L Ma Q Tian C Dong 2006 Expression and regulation of IL-22 in the IL-17-producing CD4+ T lymphocytes Cell Res 16 902 907 17088898 10.1038/sj.cr.7310106 1:CAS:528:DC%2BD28Xht1Srtb7F
16. HR Conti F Shen N Nayyar E Stocum JN Sun MJ Lindemann AW Ho JH Hai JJ Yu JW Jung SG Filler P Masso-Welch M Edgerton SL Gaffen 2009 Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis J Exp Med 206 299 311 19204111 10.1084/jem.20081463 1:CAS:528:DC%2BD1MXit1Kjtbc%3D
17. AM Cooper JE Callahan M Keen JT Belisle IM Orme 1997 Expression of memory immunity in the lung following re-exposure to Mycobacterium tuberculosis Tuber Lung Dis 78 67 73 9666964 10.1016/S0962-8479(97)90017-4 1:STN:280: DyaK1czjtFGruw%3D%3D (Pubitemid 28019789)
18. JM Coquet S Chakravarti MJ Smyth DI Godfrey 2008 Cutting edge: IL-21 is not essential for Th17 differentiation or experimental autoimmune encephalomyelitis J Immunol 180 7097 7101 18490706 1:CAS:528: DC%2BD1cXmtVant7g%3D
19. SC Cowley KL Elkins 2003 CD4+ T cells mediate IFN-gamma-independent control of Mycobacterium tuberculosis infection both in vitro and in vivo J Immunol 171 4689 4699 14568944 1:CAS:528:DC%2BD3sXot1Cnt74%3D
20. L de Beaucoudrey A Puel O Filipe-Santos A Cobat P Ghandil M Chrabieh J Feinberg H von Bernuth A Samarina L Janniere C Fieschi JL Stephan C Boileau S Lyonnet G Jondeau V Cormier-Daire M Le Merrer C Hoarau Y Lebranchu O Lortholary MO Chandesris F Tron E Gambineri L Bianchi C Rodriguez-Gallego SE Zitnik J Vasconcelos M Guedes AB Vitor L Marodi H Chapel B Reid C Roifman D Nadal J Reichenbach I Caragol BZ Garty F Dogu Y Camcioglu S Gulle O Sanal A Fischer L Abel B Stockinger C Picard JL Casanova 2008 Mutations in STAT3 and IL12RB1 impair the development of human IL-17-producing T cells J Exp Med 205 1543 1550 18591412 10.1084/jem.20080321 1:CAS:528:DC%2BD1cXosVKkt74%3D
21. ES DeLyria RW Redline TG Blanchard 2009 Vaccination of mice against H pylori induces a strong Th-17 response and immunity that is neutrophil dependent Gastroenterology 136 247 256 18948106 10.1053/j.gastro.2008.09.017 1:CAS:528:DC%2BD1MXht1Cqs7o%3D
22. X Ding HS Lillehoj MA Quiroz E Bevensee EP Lillehoj 2004 Protective immunity against Eimeria acervulina following in ovo immunization with a recombinant subunit vaccine and cytokine genes Infect Immun 72 6939 6944 15557615 10.1128/IAI.72.12.6939-6944.2004 1:CAS:528:DC%2BD2cXhtVGls7zJ (Pubitemid 39552361)
23. C Diveu MJ McGeachy DJ Cua 2008 Cytokines that regulate autoimmunity Curr Opin Immunol 20 663 668 18834938 10.1016/j.coi.2008.09.003 1:CAS:528: DC%2BD1cXhsVGgsr3L
24. A Dongari-Bagtzoglou PL Fidel Jr 2005 The host cytokine responses and protective immunity in oropharyngeal candidiasis J Dent Res 84 966 977 16246925 10.1177/154405910508401101 1:CAS:528:DC%2BD2MXht1Git7%2FM
25. C Dye MA Espinal 2001 Will tuberculosis become resistant to all antibiotics? Proc Biol Sci 268 45 52 12123297 10.1098/rspb.2000.1328 1:STN:280:DC%2BD38znslOiug%3D%3D (Pubitemid 32127952)
26. K Eriksson M Fredriksson I Nordstrom J Holmgren 2003 Cholera toxin and its B subunit promote dendritic cell vaccination with different influences on Th1 and Th2 development Infect Immun 71 1740 1747 12654787 10.1128/IAI.71.4. 1740-1747.2003 1:CAS:528:DC%2BD3sXislOhsrg%3D (Pubitemid 36368702)
27. JT Evans CW Cluff DA Johnson MJ Lacy DH Persing JR Baldridge 2003 Enhancement of antigen-specific immunity via the TLR4 ligands MPL adjuvant and Ribi. 529 Expert Rev Vaccines 2 219 229 12899573 10.1586/14760584.2.2.219 1:CAS:528:DC%2BD3sXjsVOksL0%3D (Pubitemid 36559927)
28. K Eyerich S Foerster S Rombold HP Seidl H Behrendt H Hofmann J Ring C Traidl-Hoffmann 2008 Patients with chronic mucocutaneous candidiasis exhibit reduced production of Th17-associated cytokines IL-17 and IL-22 J Invest Dermatol 128 2640 2645 18615114 10.1038/jid.2008.139 1:CAS:528: DC%2BD1cXht1CmsLvO
29. C Fromantin B Jamot J Cohen L Piroth P Pothier E Kohli 2001 Rotavirus 2/6 virus-like particles administered intranasally in mice, with or without the mucosal adjuvants cholera toxin and Escherichia coli heat-labile toxin, induce a Th1/Th2-like immune response J Virol 75 11010 11016 11602741 10.1128/JVI.75.22.11010-11016.2001 1:CAS:528:DC%2BD3MXnvVeltLo%3D (Pubitemid 33031568)
30. MC Gagliardi F Sallusto M Marinaro A Langenkamp A Lanzavecchia MT De Magistris 2000 Cholera toxin induces maturation of human dendritic cells and licences them for Th2 priming Eur J Immunol 30 2394 2403 10940931 10.1002/1521-4141(2000)30:8<2394::AID-IMMU2394>3.0.CO;2-Y 1:CAS:528:DC%2BD3cXlvFemsrs%3D (Pubitemid 30655776)
31. F Gerosa B Baldani-Guerra LA Lyakh G Batoni S Esin RT Winkler-Pickett MR Consolaro M De Marchi D Giachino A Robbiano M Astegiano A Sambataro RA Kastelein G Carra G Trinchieri 2008 Differential regulation of interleukin 12 and interleukin 23 production in human dendritic cells J Exp Med 205 1447 1461 18490488 10.1084/jem.20071450 1:CAS:528:DC%2BD1cXntFant70%3D
32. CF Gilks SA Ojoo JC Ojoo RJ Brindle J Paul BI Batchelor JN Kimari R Newnham J Bwayo FA Plummer, et al. 1996 Invasive pneumococcal disease in a cohort of predominantly HIV-1 infected female sex-workers in Nairobi, Kenya Lancet 347 718 723 8602001 10.1016/S0140-6736(96)90076-8 1:STN:280: DyaK287otFWgsw%3D%3D (Pubitemid 26085646)
33. D Greco S Salmaso P Mastrantonio M Giuliano AE Tozzi A Anemona ML Ciofi degli Atti A Giammanco P Panei WC Blackwelder DL Klein SG Wassilak 1996 A controlled trial of two acellular vaccines and one whole-cell vaccine against pertussis. Progetto Pertosse Working Group N Engl J Med 334 341 348 8538704 10.1056/NEJM199602083340601 1:STN:280:DyaK287ktVCmtA%3D%3D (Pubitemid 26053148)
34. L Gustafsson HO Hallander P Olin E Reizenstein J Storsaeter 1996 A controlled trial of a two-component acellular, a five-component acellular, and a whole-cell pertussis vaccine N Engl J Med 334 349 355 8538705 10.1056/NEJM199602083340602 1:STN:280:DyaK287ktVCmtQ%3D%3D (Pubitemid 26049587)
35. SJ Ha DJ Kim KH Baek YD Yun YC Sung 2004 IL-23 induces stronger sustained CTL and Th1 immune responses than IL-12 in hepatitis C virus envelope protein 2 DNA immunization J Immunol 172 525 531 14688363 1:CAS:528:DC%2BD3sXpvFegsro%3D
36. LE Harrington RD Hatton PR Mangan H Turner TL Murphy KM Murphy CT Weaver 2005 Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages Nat Immunol 6 1123 1132 16200070 10.1038/ni1254 1:CAS:528:DC%2BD2MXhtFamsb7J (Pubitemid 41541790)
37. C Hartoonian M Ebtekar H Soleimanjahi A Karami M Mahdavi N Rastgoo K Azadmanesh 2009 Effect of immunological adjuvants: GM-CSF (granulocyte-monocyte colony stimulating factor) and IL-23 (interleukin-23) on immune responses generated against hepatitis C virus core DNA vaccine Cytokine 46 43 50 19278866 10.1016/j.cyto.2008.12.007 1:CAS:528:DC%2BD1MXjvVyjtrw%3D
38. T Hawkridge TJ Scriba S Gelderbloem E Smit M Tameris S Moyo T Lang A Veldsman M Hatherill L Merwe HA Fletcher H Mahomed AV Hill WA Hanekom GD Hussey H McShane 2008 Safety and immunogenicity of a new tuberculosis vaccine, MVA85A, in healthy adults in South Africa J Infect Dis 198 544 552 18582195 10.1086/590185
39. SC Higgins AG Jarnicki EC Lavelle KH Mills 2006 TLR4 mediates vaccine-induced protective cellular immunity to Bordetella pertussis: role of IL-17-producing T cells J Immunol 177 7980 7989 17114471 1:CAS:528: DC%2BD28Xht1WrsLvM
40. HH Hofstetter C Grau M Buttmann TG Forsthuber S Gaupp KV Toyka R Gold 2007 The PLPp-specific T-cell population promoted by pertussis toxin is characterized by high frequencies of IL-17-producing cells Cytokine 40 35 43 17881243 10.1016/j.cyto.2007.07.192 1:CAS:528:DC%2BD2sXhtlajtr3N (Pubitemid 350088499)
41. YH Hong HS Lillehoj EP Lillehoj SH Lee 2006 Changes in immune-related gene expression and intestinal lymphocyte subpopulations following Eimeria maxima infection of chickens Vet Immunol Immunopathol 114 259 272 17045659 10.1016/j.vetimm.2006.08.006 1:CAS:528:DC%2BD28XhtFequrjJ (Pubitemid 44634731)
42. W Huang L Na PL Fidel P Schwarzenberger 2004 Requirement of interleukin-17A for systemic anti-Candida albicans host defense in mice J Infect Dis 190 624 631 15243941 10.1086/422329 1:CAS:528:DC%2BD2cXmvF2ntL8%3D (Pubitemid 38982105)
43. K Imaoka CJ Miller M Kubota MB McChesney B Lohman M Yamamoto K Fujihashi K Someya M Honda JR McGhee H Kiyono 1998 Nasal immunization of nonhuman primates with simian immunodeficiency virus p55gag and cholera toxin adjuvant induces Th1/Th2 help for virus-specific immune responses in reproductive tissues J Immunol 161 5952 5958 9834076 1:CAS:528:DyaK1cXnslCrsb0%3D
44. II Ivanov BS McKenzie L Zhou CE Tadokoro A Lepelley JJ Lafaille DJ Cua DR Littman 2006 The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells Cell 126 1121 1133 16990136 10.1016/j.cell.2006.07.035 1:CAS:528:DC%2BD28XhtVCnsrrE (Pubitemid 44380299)
45. YJ Jung L Ryan R LaCourse RJ North 2005 Properties and protective value of the secondary versus primary T helper type 1 response to airborne Mycobacterium tuberculosis infection in mice J Exp Med 201 1915 1924 15955839 10.1084/jem.20050265 1:CAS:528:DC%2BD2MXls1Witbg%3D (Pubitemid 41002928)
46. AT Kamath AF Rochat D Christensen EM Agger P Andersen PH Lambert CA Siegrist 2009 A Liposome-based mycobacterial vaccine induces potent adult and neonatal multifunctional T cells through the exquisite targeting of dendritic cells PLoS ONE 4 e5771 19492047 10.1371/journal.pone.0005771 1:CAS:528:DC%2BD1MXnt1Slu7g%3D
47. SA Khader GK Bell JE Pearl JJ Fountain J Rangel-Moreno GE Cilley F Shen SM Eaton SL Gaffen SL Swain RM Locksley L Haynes TD Randall AM Cooper 2007 IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge Nat Immunol 8 369 377 17351619 10.1038/ni1449 1:CAS:528:DC%2BD2sXjt1SqsLY%3D (Pubitemid 46745412)
48. SA Khader SL Gaffen JK Kolls 2009 Th17 cells at the crossroads of innate and adaptive immunity against infectious diseases at the mucosa Mucosal Immunol 2 403 411 19587639 10.1038/mi.2009.100 1:CAS:528:DC%2BD1MXpvFygs7o%3D
49. SA Khader JE Pearl K Sakamoto L Gilmartin GK Bell DM Jelley-Gibbs N Ghilardi F deSauvage AM Cooper 2005 IL-23 compensates for the absence of IL-12p70 and is essential for the IL-17 response during tuberculosis but is dispensable for protection and antigen-specific IFN-gamma responses if IL-12p70 is available J Immunol 175 788 795 16002675 1:CAS:528:DC%2BD2MXlvFSjsb4%3D
50. T Korn E Bettelli W Gao A Awasthi A Jager TB Strom M Oukka VK Kuchroo 2007 IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells Nature 448 484 487 17581588 10.1038/nature05970 1:CAS:528: DC%2BD2sXotFajurw%3D (Pubitemid 47123515)
51. T Korn E Bettelli M Oukka VK Kuchroo 2009 IL-17 and Th17 Cells Annu Rev Immunol 27 485 517 19132915 10.1146/annurev.immunol.021908.132710 1:CAS:528:DC%2BD1MXlsFSltrY%3D
52. A la Sala J He L Laricchia-Robbio S Gorini A Iwasaki M Braun GS Yap A Sher K Ozato B Kelsall 2009 Cholera toxin inhibits IL-12 production and CD8alpha + dendritic cell differentiation by cAMP-mediated inhibition of IRF8 function J Exp Med 206 1227 1235 19487420 10.1084/jem.20080912 1:CAS:528: DC%2BD1MXntFGmurc%3D
53. CL Langrish Y Chen WM Blumenschein J Mattson B Basham JD Sedgwick T McClanahan RA Kastelein DJ Cua 2005 IL-23 drives a pathogenic T cell population that induces autoimmune inflammation J Exp Med 201 233 240 15657292 10.1084/jem.20041257 1:CAS:528:DC%2BD2MXot12mtA%3D%3D (Pubitemid 40189432)
54. A Laurence CM Tato TS Davidson Y Kanno Z Chen Z Yao RB Blank F Meylan R Siegel L Hennighausen EM Shevach JJ O'Shea 2007 Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation Immunity 26 371 381 17363300 10.1016/j.immuni.2007.02.009 1:CAS:528:DC%2BD2sXjvVSnsL8%3D (Pubitemid 46413906)
55. IS Leal B Smedegard P Andersen R Appelberg 2001 Failure to induce enhanced protection against tuberculosis by increasing T-cell-dependent interferon-gamma generation Immunology 104 157 161 11683955 10.1046/j.1365-2567. 2001.01305.x 1:CAS:528:DC%2BD3MXotlahsb8%3D (Pubitemid 32989516)
56. JB Lee JE Jang MK Song J Chang 2009 Intranasal delivery of cholera toxin induces th17-dominated T-cell response to bystander antigens PLoS ONE 4 e5190 19360100 10.1371/journal.pone.0005190 1:CAS:528:DC%2BD1MXltFGntbs%3D
57. S LeibundGut-Landmann O Gross MJ Robinson F Osorio EC Slack SV Tsoni E Schweighoffer V Tybulewicz GD Brown J Ruland C Reis e Sousa 2007 Syk-and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17 Nat Immunol 8 630 638 17450144 10.1038/ni1460 1:CAS:528:DC%2BD2sXlsVSrs78%3D (Pubitemid 46785127)
58. SC Liang XY Tan DP Luxenberg R Karim K Dunussi-Joannopoulos M Collins LA Fouser 2006 Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides J Exp Med 203 2271 2279 16982811 10.1084/jem.20061308 1:CAS:528:DC%2BD28XhtVGls7fF (Pubitemid 44498362)
59. Z Liu H Lin Q Liu G Mousavi WC Gause 2008 The parasite Nippostrongylus brasiliensis induces multiple regulatory pathways that control increases of IL-17 expression and associated pathology in the lung Faseb J 22 84836
60. Y Liu B Yang M Zhou L Li H Zhou J Zhang H Chen C Wu 2009 Memory IL-22-producing CD4+ T cells specific for Candida albicans are present in humans Eur J Immunol 39 1472 1479 19449309 10.1002/eji.200838811 1:CAS:528: DC%2BD1MXntFCitbs%3D
61. V Lombardi L Van Overtvelt S Horiot P Moingeon 2009 Human dendritic cells stimulated via TLR7 and/or TLR8 induce the sequential production of Il-10, IFN-gamma, and IL-17A by naive CD4+ T cells J Immunol 182 3372 3379 19265114 10.4049/jimmunol.0801969 1:CAS:528:DC%2BD1MXis12is70%3D
62. YJ Lu S Forte CM Thompson PW Anderson R Malley 2009 Protection against Pneumococcal colonization and fatal pneumonia by a trivalent conjugate of a fusion protein with the cell wall polysaccharide Infect Immun 77 2076 2083 19255193 10.1128/IAI.01554-08 1:CAS:528:DC%2BD1MXlsFSkurY%3D
63. YJ Lu J Gross D Bogaert A Finn L Bagrade Q Zhang JK Kolls A Srivastava A Lundgren S Forte CM Thompson KF Harney PW Anderson M Lipsitch R Malley 2008 Interleukin-17A mediates acquired immunity to pneumococcal colonization PLoS Pathog 4 e1000159 18802458 10.1371/journal.ppat.1000159 1:CAS:528: DC%2BD1cXht1ygsbbI
64. R Malley A Srivastava M Lipsitch CM Thompson C Watkins A Tzianabos PW Anderson 2006 Antibody-independent, interleukin-17A-mediated, cross-serotype immunity to pneumococci in mice immunized intranasally with the cell wall polysaccharide Infect Immun 74 2187 2195 16552049 10.1128/IAI.74.4.2187-2195. 2006 1:CAS:528:DC%2BD28XjsVWhsL8%3D
65. M Marinaro PN Boyaka RJ Jackson FD Finkelman H Kiyono E Jirillo JR McGhee 1999 Use of intranasal IL-12 to target predominantly Th1 responses to nasal and Th2 responses to oral vaccines given with cholera toxin J Immunol 162 114 121 9886376 1:CAS:528:DyaK1MXjt1Kqsw%3D%3D
66. M Marinaro HF Staats T Hiroi RJ Jackson M Coste PN Boyaka N Okahashi M Yamamoto H Kiyono H Bluethmann K Fujihashi JR McGhee 1995 Mucosal adjuvant effect of cholera toxin in mice results from induction of T helper 2 (Th2) cells and IL-4 J Immunol 155 4621 4629 7594461 1:CAS:528:DyaK2MXptlaqurY%3D
67. M Marta A Andersson M Isaksson O Kampe A Lobell 2008 Unexpected regulatory roles of TLR4 and TLR9 in experimental autoimmune encephalomyelitis Eur J Immunol 38 565 575 18203139 10.1002/eji.200737187 1:CAS:528: DC%2BD1cXisVehsbc%3D
68. M Matsui O Moriya ML Belladonna S Kamiya FA Lemonnier T Yoshimoto T Akatsuka 2004 Adjuvant activities of novel cytokines, interleukin-23 (IL-23) and IL-27, for induction of hepatitis C virus-specific cytotoxic T lymphocytes in HLA-A*0201 transgenic mice J Virol 78 9093 9104 15308705 10.1128/JVI.78.17.9093-9104.2004 1:CAS:528:DC%2BD2cXntVKiu70%3D (Pubitemid 39096520)
69. AC Maue SM Eaton PA Lanthier KB Sweet SL Blumerman L Haynes 2009 Proinflammatory adjuvants enhance the cognate helper activity of aged CD4 T cells J Immunol 182 6129 6135 19414765 10.4049/jimmunol.0804226 1:CAS:528:DC%2BD1MXltlynt7k%3D
70. Mayhall CG (2004) Hospital epidemiology and infection control. Williams and Wilkins, New York, pp 1619-1620
71. AL McGowen LP Hale CP Shelburne SN Abraham HF Staats 2009 The mast cell activator compound 48/80 is safe and effective when used as an adjuvant for intradermal immunization with Bacillus anthracis protective antigen Vaccine 27 3544 3552 19464533 10.1016/j.vaccine.2009.03.069 1:CAS:528:DC%2BD1MXmtlKktbg%3D
72. MM McNeal M Basu JA Bean JD Clements NY Lycke A Ramne B Lowenadler AH Choi RL Ward 2007 Intrarectal immunization of mice with VP6 and either LT(R192G) or CTA1-DD as adjuvant protects against fecal rotavirus shedding after EDIM challenge Vaccine 25 6224 6231 17629371 10.1016/j.vaccine.2007.05.065 1:CAS:528:DC%2BD2sXotlSntbo%3D (Pubitemid 47088036)
73. MM McNeal SC Stone M Basu JD Clements AH Choi RL Ward 2007 IFN-gamma is the only anti-rotavirus cytokine found after in vitro stimulation of memory CD4+ T cells from mice immunized with a chimeric VP6 protein Viral Immunol 20 571 584 18158731 10.1089/vim.2007.0055 1:CAS:528:DC%2BD2sXhsVKitb%2FO
74. KH Mills 2001 Immunity to Bordetella pertussis Microbes Infect 3 655 677 11445452 10.1016/S1286-4579(01)01421-6 1:CAS:528:DC%2BD3MXltVGjurg%3D (Pubitemid 32607761)
75. JD Milner JM Brenchley A Laurence AF Freeman BJ Hill KM Elias Y Kanno C Spalding HZ Elloumi ML Paulson J Davis A Hsu AI Asher J O'Shea SM Holland WE Paul DC Douek 2008 Impaired T(H)17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome Nature 452 773 776 18337720 10.1038/nature06764 1:CAS:528:DC%2BD1cXksFSisr8%3D
76. TR Mosmann H Cherwinski MW Bond MA Giedlin RL Coffman 1986 Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins J Immunol 136 2348 2357 2419430 1:CAS:528:DyaL28XhvVClsbk%3D
77. TV Murphy PM Gargiullo MS Massoudi DB Nelson AO Jumaan CA Okoro LR Zanardi S Setia E Fair CW LeBaron M Wharton JR Livengood 2001 Intussusception among infants given an oral rotavirus vaccine N Engl J Med 344 564 572 11207352 10.1056/NEJM200102223440804 1:STN:280:DC%2BD3M7ksVegug%3D%3D (Pubitemid 32167870)
78. S Nakae A Nambu K Sudo Y Iwakura 2003 Suppression of immune induction of collagen-induced arthritis in IL-17-deficient mice J Immunol 171 6173 6177 14634133 1:CAS:528:DC%2BD3sXptFOktrg%3D
79. M Nasso G Fedele F Spensieri R Palazzo P Costantino R Rappuoli CM Ausiello 2009 Genetically detoxified pertussis toxin induces Th1/Th17 immune response through MAPKs and IL-10-dependent mechanisms J Immunol 183 1892 1899 19596995 10.4049/jimmunol.0901071 1:CAS:528:DC%2BD1MXoslCrs7k%3D
80. R Nurieva XO Yang G Martinez Y Zhang AD Panopoulos L Ma K Schluns Q Tian SS Watowich AM Jetten C Dong 2007 Essential autocrine regulation by IL-21 in the generation of inflammatory T cells Nature 448 480 483 17581589 10.1038/nature05969 1:CAS:528:DC%2BD2sXotFajur8%3D (Pubitemid 47123514)
81. B Oppmann R Lesley B Blom JC Timans Y Xu B Hunte F Vega N Yu J Wang K Singh F Zonin E Vaisberg T Churakova M Liu D Gorman J Wagner S Zurawski Y Liu JS Abrams KW Moore D Rennick R de Waal-Malefyt C Hannum JF Bazan RA Kastelein 2000 Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12 Immunity 13 715 725 11114383 10.1016/S1074-7613(00)00070-4 1:CAS:528:DC%2BD3cXovV2ht7c%3D
82. UD Parashar EG Hummelman JS Bresee MA Miller RI Glass 2003 Global illness and deaths caused by rotavirus disease in children Emerg Infect Dis 9 565 572 12737740
83. H Park Z Li XO Yang SH Chang R Nurieva YH Wang Y Wang L Hood Z Zhu Q Tian C Dong 2005 A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17 Nat Immunol 6 1133 1141 16200068 10.1038/ni1261 1:CAS:528:DC%2BD2MXhtFamsb%2FO (Pubitemid 41541791)
84. MGR Pitta A Romano S Cabantous S Henri A Hammad B Kouriba L Argiro ME Kheir B Bucheton C Mary SH El-Sari A Dessein 2009 IL-17 and IL-22 are associated with protection against human kala azar caused by Leishmania donovani J Clin Invest 119 8
85. GP Priebe MM Brinig K Hatano M Grout FT Coleman GB Pier JB Goldberg 2002 Construction and characterization of a live, attenuated aroA deletion mutant of Pseudomonas aeruginosa as a candidate intranasal vaccine Infect Immun 70 1507 1517 11854239 10.1128/IAI.70.3.1507-1517.2002 1:CAS:528:DC%2BD38XhsFSltrs%3D (Pubitemid 34163430)
86. GP Priebe RL Walsh TA Cederroth A Kamei YS Coutinho-Sledge JB Goldberg GB Pier 2008 IL-17 is a critical component of vaccine-induced protection against lung infection by lipopolysaccharide-heterologous strains of Pseudomonas aeruginosa J Immunol 181 4965 4975 18802100 1:CAS:528:DC%2BD1cXhtFarurfF
87. M Romano S D'Souza PY Adnet R Laali F Jurion K Palfliet K Huygen 2006 Priming but not boosting with plasmid DNA encoding mycolyl-transferase Ag85A from Mycobacterium tuberculosis increases the survival time of Mycobacterium bovis BCG vaccinated mice against low dose intravenous challenge with M. tuberculosis H37Rv Vaccine 24 3353 3364 16488518 10.1016/j.vaccine.2005.12.066 1:CAS:528:DC%2BD28XivFSjsL4%3D
88. RE Roses S Xu M Xu U Koldovsky G Koski BJ Czerniecki 2008 Differential production of IL-23 and IL-12 by myeloid-derived dendritic cells in response to TLR agonists J Immunol 181 5120 5127 18802116 1:CAS:528:DC%2BD1cXhtFaru73K
89. XL Rudner KI Happel EA Young JE Shellito 2007 Interleukin-23 (IL-23)-IL-17 Cytokine Axis in Murine Pneumocystis carnii Infection Infect Immun 2007 3055 3061 10.1128/IAI.01329-06 1:CAS:528:DC%2BD2sXmtlKmsbc%3D (Pubitemid 46870190)
90. GM Ruiz-Palacios I Perez-Schael FR Velazquez H Abate T Breuer SC Clemens B Cheuvart F Espinoza P Gillard BL Innis Y Cervantes AC Linhares P Lopez M Macias-Parra E Ortega-Barria V Richardson DM Rivera-Medina L Rivera B Salinas N Pavia-Ruz J Salmeron R Ruttimann JC Tinoco P Rubio E Nunez ML Guerrero JP Yarzabal S Damaso N Tornieporth X Saez-Llorens RF Vergara T Vesikari A Bouckenooghe R Clemens B De Vos M O'Ryan 2006 Safety and efficacy of an attenuated vaccine against severe rotavirus gastroenteritis N Engl J Med 354 11 22 16394298 10.1056/NEJMoa052434 1:CAS:528:DC%2BD28XhvVWltw%3D%3D (Pubitemid 43048947)
91. LI Rutitzky L Bazzone MG Shainheit B Joyce-Shaikh DJ Cua MJ Stadecker 2008 IL-23 is required for the development of severe egg-induced immunopathology in schistosomiasis and for lesional expression of IL-17 J Immunol 180 2486 2495 18250458 1:CAS:528:DC%2BD1cXhsVSgsr0%3D
92. LI Rutitzky JR Lopes da Rosa MJ Stadecker 2005 Severe CD4 T cell-mediated immunopathology in murine schistosomiasis is dependent on IL-12p40 and correlates with high levels of IL-17 J Immunol 175 3920 3926 16148138 1:CAS:528:DC%2BD2MXpslClsLk%3D
93. EJ Ryan E McNeela M Pizza R Rappuoli L O'Neill KH Mills 2000 Modulation of innate and acquired immune responses by Escherichia coli heat-labile toxin: distinct pro- and anti-inflammatory effects of the nontoxic AB complex and the enzyme activity J Immunol 165 5750 5759 11067933 1:CAS:528:DC%2BD3cXot1Grsbg%3D
94. TJ Scriba B Kalsdorf DA Abrahams F Isaacs J Hofmeister G Black HY Hassan RJ Wilkinson G Walzl SJ Gelderbloem H Mahomed GD Hussey WA Hanekom 2008 Distinct, specific IL-17- and IL-22-producing CD4+ T cell subsets contribute to the human anti-mycobacterial immune response J Immunol 180 1962 1970 18209095 1:CAS:528:DC%2BD1cXotlKktQ%3D%3D
95. KL Smiley MM McNeal M Basu AH Choi JD Clements RL Ward 2007 Association of gamma interferon and interleukin-17 production in intestinal CD4+ T cells with protection against rotavirus shedding in mice intranasally immunized with VP6 and the adjuvant LT(R192G) J Virol 81 3740 3748 17251301 10.1128/JVI.01877-06 1:CAS:528:DC%2BD2sXksVKlurg%3D (Pubitemid 46586871)
96. JS Stumhofer A Laurence EH Wilson E Huang CM Tato LM Johnson AV Villarino Q Huang A Yoshimura D Sehy CJ Saris JJ O'Shea L Hennighausen M Ernst CA Hunter 2006 Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system Nat Immunol 7 937 945 16906166 10.1038/ni1376 1:CAS:528: DC%2BD28XotlCitbs%3D (Pubitemid 44263907)
97. AJ van Beelen Z Zelinkova EW Taanman-Kueter FJ Muller DW Hommes SA Zaat ML Kapsenberg EC de Jong 2007 Stimulation of the intracellular bacterial sensor NOD2 programs dendritic cells to promote interleukin-17 production in human memory T cells Immunity 27 660 669 17919942 10.1016/j.immuni.2007.08.013 1:CAS:528:DC%2BD2sXht1ygurzL (Pubitemid 47615504)
98. FL van de Veerdonk RJ Marijnissen BJ Kullberg HJ Koenen SC Cheng I Joosten WB van den Berg DL Williams JW van der Meer LA Joosten MG Netea 2009 The macrophage mannose receptor induces IL-17 in response to Candida albicans Cell Host Microbe 5 329 340 19380112 10.1016/j.chom.2009.02.006 1:CAS:528: DC%2BD1MXls1Sqtr0%3D
99. JL VanCott AE Prada MM McNeal SC Stone M Basu B Huffer Jr KL Smiley M Shao JA Bean JD Clements AH Choi RL Ward 2006 Mice develop effective but delayed protective immune responses when immunized as neonates either intranasally with nonliving VP6/LT(R192G) or orally with live rhesus rotavirus vaccine candidates J Virol 80 4949 4961 16641286 10.1128/JVI.80.10.4949-4961.2006 1:CAS:528:DC%2BD28XkslChtb0%3D
100. D Velin L Favre E Bernasconi D Bachmann C Pythoud E Saiji H Bouzourene P Michetti 2009 Interleukin-17 is a critical mediator of vaccine-induced reduction of helicobacter infection in the mouse model Gastroenterology 136 2237-2246 e1 19272385
101. T Vesikari AV Karvonen J Majuri SQ Zeng XL Pang R Kohberger BD Forrest Y Hoshino RM Chanock AZ Kapikian 2006 Safety, efficacy, and immunogenicity of 2 doses of bovine-human (UK) and rhesus-rhesus-human rotavirus reassortant tetravalent vaccines in Finnish children J Infect Dis 194 370 376 16826486 10.1086/505151 (Pubitemid 44116980)
102. HM Vordermeier B Villarreal-Ramos PJ Cockle M Macaulay SG Rhodes T Thacker SC Gilbert H McShane AV Hill RZ Xing RG Hewinson 2009 Viral booster vaccines improve BCG-induced protection Against bovine Tuberculosis Infect Immun 77 3364 3373 19487476 10.1128/IAI.00287-09 1:CAS:528:DC%2BD1MXpsFCmu7o%3D
103. JL Werner AE Metz D Horn TR Schoeb MM Hewitt LM Schwiebert I Faro-Trindade GD Brown C Steele 2009 Requisite role for the dectin-1 beta-glucan receptor in pulmonary defense against Aspergillus fumigatus J Immunol 182 4938 4946 19342673 10.4049/jimmunol.0804250 1:CAS:528:DC%2BD1MXjvFOju7c%3D
104. K Werninghaus A Babiak O Gross C Holscher H Dietrich EM Agger J Mages A Mocsai H Schoenen K Finger F Nimmerjahn GD Brown C Kirschning A Heit P Andersen H Wagner J Ruland R Lang 2009 Adjuvanticity of a synthetic cord factor analogue for subunit Mycobacterium tuberculosis vaccination requires FcRgamma-Syk-Card9- dependent innate immune activation J Exp Med 206 89 97 19139169 10.1084/jem.20081445 1:CAS:528:DC%2BD1MXhtVOhtbc%3D
105. World Health Organization (2006) State of the art of new vaccines: research and development. www.who.int/vaccines-documents/DOCSPDF06/814.pdf
106. J Williman E Lockhart L Slobbe G Buchan M Baird 2006 The use of Th1 cytokines, IL-12 and IL-23, to modulate the immune response raised to a DNA vaccine delivered by gene gun Vaccine 24 4471 4474 16140432 10.1016/j.vaccine. 2005.08.011 1:CAS:528:DC%2BD28XltF2rt7w%3D (Pubitemid 43776785)
107. J Williman S Young G Buchan L Slobbe M Wilson P Pang J Austyn S Preston M Baird 2008 DNA fusion vaccines incorporating IL-23 or RANTES for use in immunization against influenza Vaccine 26 5153 5158 18456374 10.1016/j.vaccine.2008.03.084 1:CAS:528:DC%2BD1cXhtVygurjO
108. TM Wozniak AA Ryan JA Triccas WJ Britton 2006 Plasmid interleukin-23 (IL-23), but not plasmid IL-27, enhances the protective efficacy of a DNA vaccine against Mycobacterium tuberculosis infection Infect Immun 74 557 565 16369012 10.1128/IAI.74.1.557-565.2006 1:CAS:528:DC%2BD28XitlKrsw%3D%3D (Pubitemid 43023111)
109. J Xu-Amano H Kiyono RJ Jackson HF Staats K Fujihashi PD Burrows CO Elson S Pillai JR McGhee 1993 Helper T cell subsets for immunoglobulin A responses:
110. S Yamamoto H Kiyono M Yamamoto K Imaoka K Fujihashi FW Van Ginkel M Noda Y Takeda JR McGhee 1997 A nontoxic mutant of cholera toxin elicits Th2-type responses for enhanced mucosal immunity Proc Natl Acad Sci USA 94 5267 5272 9144226 10.1073/pnas.94.10.5267 1:CAS:528:DyaK2sXjtlentLc%3D (Pubitemid 27214772)
111. XO Yang BP Pappu R Nurieva A Akimzhanov HS Kang Y Chung L Ma B Shah AD Panopoulos KS Schluns SS Watowich Q Tian AM Jetten C Dong 2008 T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma Immunity 28 29 39 18164222 10.1016/j.immuni.2007.11.016 1:CAS:528:DC%2BD1cXht1Ontrs%3D
112. FY Yue A Merchant CM Kovacs M Loutfy D Persad MA Ostrowski 2008 Virus-specific interleukin-17-producing CD4+ T cells are detectable in early human immunodeficiency virus type 1 infection J Virol 82 6767 6771 18434403 10.1128/JVI.02550-07 1:CAS:528:DC%2BD1cXnslyqtLo%3D
113. T Zelante A De Luca P Bonifazi C Montagnoli S Bozza S Moretti ML Belladonna C Vacca C Conte P Mosci F Bistoni P Puccetti RA Kastelein M Kopf L Romani 2007 IL-23 and the Th17 pathway promote inflammation and impair antifungal immune resistance Eur J Immunol 37 2695 2706 17899546 10.1002/eji.200737409 1:CAS:528:DC%2BD2sXht1ersr3J (Pubitemid 47578289)
114. Z Zhang TB Clarke JN Weiser 2009 Cellular effectors mediating Th17-dependent clearance of pneumococcal colonization in mice J Clin Invest 119 1899 1909 19509469 1:CAS:528:DC%2BD1MXosVCrsr8%3D
115. Y Zheng PA Valdez DM Danilenko Y Hu SM Sa Q Gong AR Abbas Z Modrusan N Ghilardi FJ de Sauvage W Ouyang 2008 Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens Nat Med 14 282 289 18264109 10.1038/nm1720 1:CAS:528:DC%2BD1cXivFOrtLw%3D
116. M Zhou B Yang R Ma C Wu 2008 Memory Th-17 cells specific for C. albicans are persistent in human peripheral blood Immunol Lett 118 72 81 18440075 10.1016/j.imlet.2008.03.004 1:CAS:528:DC%2BD1cXmtlSku7Y%3D